Search Results - "Gottardis, M M"

Castration-Resistant Prostate Cancer: Locking Up the Molecular Escape Routes by ATTAR, Ricardo M, TAKIMOTO, Chris H, GOTTARDIS, Marco M

“…The understanding of the key role that androgens play on the normal and pathological physiology of the prostate guided the development of different therapies…”
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Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes by NOVOSYADLYY, Ruslan, LANN, Danielle E, KURSHAN, Naamit, MEJIA, Wilson, SANTOPIETRO, Stefania, YAKAR, Shoshana, WOOD, Teresa L, LEROITH, Derek, VIJAYAKUMAR, Archana, ROWZEE, Anne, LAZZARINO, Deborah A, FIERZ, Yvonne, CARBONI, Joan M, GOTTARDIS, Marco M, PENNISI, Patricia A, MOLINOLO, Alfredo A

“…Epidemiologic studies suggest that type 2 diabetes (T2D) increases breast cancer risk and mortality, but there is limited experimental evidence supporting this…”
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BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR by Carboni, Joan M, Wittman, Mark, Yang, Zheng, Lee, Francis, Greer, Ann, Hurlburt, Warren, Hillerman, Stephen, Cao, Carolyn, Cantor, Glenn H, Dell-John, Janet, Chen, Cliff, Discenza, Lorell, Menard, Krista, Li, Aixin, Trainor, George, Vyas, Dolatrai, Kramer, Robert, Attar, Ricardo M, Gottardis, Marco M

“…BMS-754807 is a potent and reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases (Ki, <2 nmol/L). It is currently…”
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Constitutively Active Type I Insulin-Like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and Is Accompanied by an Epithelial-to-Mesenchymal Transition Mediated by NF-κB and Snail by Kim, Hyun-Jung, Litzenburger, Beate C., Cui, Xiaojiang, Delgado, David A., Grabiner, Brian C., Lin, Xin, Lewis, Michael T., Gottardis, Marco M., Wong, Tai W., Attar, Ricardo M., Carboni, Joan M., Lee, Adrian V.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Drug safety is a barrier to the discovery and development of new androgen receptor antagonists by Foster, William R., Car, Bruce D., Shi, Hong, Levesque, Paul C., Obermeier, Mary T., Gan, Jinping, Arezzo, Joseph C., Powlin, Stephanie S., Dinchuk, Joseph E., Balog, Aaron, Salvati, Mark E., Attar, Ricardo M., Gottardis, Marco M.

“…BACKGROUND Androgen receptor (AR) antagonists are part of the standard of care for prostate cancer. Despite the almost inevitable development of resistance in…”
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Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2 by Purandare, A V, McDevitt, T M, Wan, H, You, D, Penhallow, B, Han, X, Vuppugalla, R, Zhang, Y, Ruepp, S U, Trainor, G L, Lombardo, L, Pedicord, D, Gottardis, M M, Ross-Macdonald, P, de Silva, H, Hosbach, J, Emanuel, S L, Blat, Y, Fitzpatrick, E, Taylor, T L, McIntyre, K W, Michaud, E, Mulligan, C, Lee, F Y, Woolfson, A, Lasho, T L, Pardanani, A, Tefferi, A, Lorenzi, M V

“…We report the characterization of BMS-911543, a potent and selective small-molecule inhibitor of the Janus kinase (JAK) family member, JAK2. Functionally,…”
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A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation by Tognon, C E, Martin, M J, Moradian, A, Trigo, G, Rotblat, B, Cheng, S-W G, Pollard, M, Uy, E, Chow, C, Carboni, J M, Gottardis, M M, Pollak, M, Morin, G B, Sorensen, P H B

“…ETV6-NTRK3 (EN), a chimeric tyrosine kinase generated by t(12;15) translocations, is a dominantly acting oncoprotein in diverse tumor types. We previously…”
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HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924 by Haluska, Paul, Carboni, Joan M, TenEyck, Cynthia, Attar, Ricardo M, Hou, Xiaonan, Yu, Chunrong, Sagar, Malvika, Wong, Tai W, Gottardis, Marco M, Erlichman, Charles

“…We have reported previously the activity of the insulin-like growth factor-I (IGF-IR)/insulin receptor (InsR) inhibitor, BMS-554417, in breast and ovarian…”
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Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development by Wittman, Mark D, Carboni, Joan M, Yang, Zheng, Lee, Francis Y, Antman, Melissa, Attar, Ricardo, Balimane, Praveen, Chang, Chiehying, Chen, Cliff, Discenza, Lorell, Frennesson, David, Gottardis, Marco M, Greer, Ann, Hurlburt, Warren, Johnson, Walter, Langley, David R, Li, Aixin, Li, Jianqing, Liu, Peiying, Mastalerz, Harold, Mathur, Arvind, Menard, Krista, Patel, Karishma, Sack, John, Sang, Xiaopeng, Saulnier, Mark, Smith, Daniel, Stefanski, Kevin, Trainor, George, Velaparthi, Upender, Zhang, Guifen, Zimmermann, Kurt, Vyas, Dolatrai M

“…This report describes the biological activity, characterization, and SAR leading to 9d (BMS-754807) a small molecule IGF-1R kinase inhibitor in clinical…”
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ETV6-NTRK3―Mediated Breast Epithelial Cell Transformation Is Blocked by Targeting the IGF1R Signaling Pathway by TOGNON, Cristina E, SOMASIRI, Aruna M, SORENSEN, Poul H. B, EVDOKIMOVA, Valentina E, TRIGO, Genny, UY, Evett E, MELNYK, Nataliya, CARBONI, Joan M, GOTTARDIS, Marco M, ROSKELLEY, Calvin D, POLLAK, Michael

“…The insulin-like growth factor (IGF) 1 receptor (IGF1R) is an important therapeutic target under study in many cancers. Here, we describe a breast cancer model…”
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Molecular markers for novel therapies in neuroendocrine (carcinoid) tumors by Gilbert, Judith A, Adhikari, Laura J, Lloyd, Ricardo V, Rubin, Joseph, Haluska, Paul, Carboni, Joan M, Gottardis, Marco M, Ames, Matthew M

“…Neuroendocrine (carcinoid) tumors (NETs) are endocrine neoplasms occurring most frequently in gastrointestinal and bronchopulmonary (BP) systems. The majority…”
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Combined Inhibition of IGF-1R/IR and Src family kinases enhances antitumor effects in prostate cancer by decreasing activated survival pathways by Dayyani, Farshid, Parikh, Nila U, Varkaris, Andreas S, Song, Jian H, Moorthy, Shhyam, Chatterji, Tanushree, Maity, Sankar N, Wolfe, Adam R, Carboni, Joan M, Gottardis, Marco M, Logothetis, Christopher J, Gallick, Gary E

“…Treatment of metastatic prostate cancer (PCa) with single agents has shown only modest efficacy. We hypothesized dual inhibition of different pathways in PCa…”
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Effect of cadmium on estrogen receptor levels and estrogen-induced responses in human breast cancer cells by Garcia-Morales, P, Saceda, M, Kenney, N, Kim, N, Salomon, D S, Gottardis, M M, Solomon, H B, Sholler, P F, Jordan, V C, Martin, M B

“…The effects of cadmium on estrogen receptor and other estrogen-regulated genes in the human breast cancer cell line MCF-7 were studied. Treatment of MCF-7…”
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Decreased Egr‐1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation by Huang, Ruo‐Pan, Fan, Yan, De Belle, Ian, Niemeyer, Christina, Gottardis, Marco M., Mercola, Dan, Adamson, Eileen D.

“…We have examined several types of tumor cell lines and shown that they invariably expressed little or no Egr‐1, in contrast to their normal counterparts. We…”
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Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor by CONNOR, Caroline E, NORRIS, John D, BROADWATER, Gloria, WILLSON, Timothy M, GOTTARDIS, Marco M, DEWHIRST, Mark W, MCDONNELL, Donald P

“…Tamoxifen inhibits estrogen receptor (ER) transcriptional activity by competitively inhibiting estradiol binding and inducing conformational changes in the…”
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BMS-536924 Reverses IGF-IR-Induced Transformation of Mammary Epithelial Cells and Causes Growth Inhibition and Polarization of MCF7 Cells by Litzenburger, Beate C, Kim, Hyun-Jung, Kuiatse, Isere, Carboni, Joan M, Attar, Ricardo M, Gottardis, Marco M, Fairchild, Craig R, Lee, Adrian V

“…Purpose: This study aimed to test the ability of a new insulin-like growth factor receptor ( IGF-IR ) tyrosine kinase inhibitor, BMS-536924, to reverse the…”
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Beyond tamoxifen : The retinoid X receptor-selective ligand LGD1069 (targretin) causes complete regression of mammary carcinoma by BISCHOFF, E. D, GOTTARDIS, M. M, MOON, T. E, HEYMAN, R. A, LAMPH, W. W

“…Recently, we reported that LGD1069, a high-affinity ligand for the retinoid X receptors (RXRs), was shown to have an efficacy equivalent to that of tamoxifen…”
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A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor by Emanuel, Stuart L., Engle, Linda J., Chao, Ginger, Zhu, Rong-Rong, Cao, Carolyn, Lin, Zheng, Yamniuk, Aaron P., Hosbach, Jennifer, Brown, Jennifer, Fitzpatrick, Elizabeth, Gokemeijer, Jochem, Morin, Paul, Morse, Brent A., Carvajal, Irvith M., Fabrizio, David, Wright, Martin C., Das Gupta, Ruchira, Gosselin, Michael, Cataldo, Daniel, Ryseck, Rolf P., Doyle, Michael L., Wong, Tai W., Camphausen, Raymond T., Cload, Sharon T., Marsh, H. Nicholas, Gottardis, Marco M., Furfine, Eric S.

“…Engineered domains of human fibronectin (Adnectins™) were used to generate a bispecific Adnectin targeting epidermal growth factor receptor (EGFR) and…”
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GREB1 is a novel androgen-regulated gene required for prostate cancer growth by Rae, James M., Johnson, Michael D., Cordero, Kevin E., Scheys, Joshua O., Larios, José M., Gottardis, Marco M., Pienta, Kenneth J., Lippman, Marc E.

“…BACKGROUND Gene regulated in breast cancer 1 (GREB1) is a novel estrogen‐regulated gene shown to play a pivotal role in hormone‐stimulated breast cancer…”
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Chemoprevention of mammary carcinoma by LGD1069 (Targretin) : An RXR-selective ligand by GOTTARDIS, M. M, BISCHOFF, E. D, SHIRLEY, M. A, WAGONER, M. A, LAMPH, W. W, HEYMAN, R. A

“…Recently, 9-cis retinoic acid, a high affinity ligand for retinoic acid receptors and retinoid X-receptors (RXRs), was shown to have efficacy superior to…”
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