Search Results - "Gotta, M"

Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications by Friedland, Ari E, Baral, Reshica, Singhal, Pankhuri, Loveluck, Katherine, Shen, Shen, Sanchez, Minerva, Marco, Eugenio, Gotta, Gregory M, Maeder, Morgan L, Kennedy, Edward M, Kornepati, Anand V R, Sousa, Alexander, Collins, McKensie A, Jayaram, Hari, Cullen, Bryan R, Bumcrot, David

“…CRISPR-Cas systems have been broadly embraced as effective tools for genome engineering applications, with most studies to date utilizing the Streptococcus…”
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Reference Scales for the Characterization of Cationic Electrophiles and Neutral Nucleophiles by Mayr, Herbert, Bug, Thorsten, Gotta, Matthias F, Hering, Nicole, Irrgang, Bernhard, Janker, Brigitte, Kempf, Bernhard, Loos, Robert, Ofial, Armin R, Remennikov, Grigoriy, Schimmel, Holger

“…Twenty-three diarylcarbenium ions and 38 π-systems (arenes, alkenes, allyl silanes and stannanes, silyl enol ethers, silyl ketene acetals, and enamines) have…”
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Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10 by Maeder, Morgan L., Stefanidakis, Michael, Wilson, Christopher J., Baral, Reshica, Barrera, Luis Alberto, Bounoutas, George S., Bumcrot, David, Chao, Hoson, Ciulla, Dawn M., DaSilva, Jennifer A., Dass, Abhishek, Dhanapal, Vidya, Fennell, Tim J., Friedland, Ari E., Giannoukos, Georgia, Gloskowski, Sebastian W., Glucksmann, Alexandra, Gotta, Gregory M., Jayaram, Hariharan, Haskett, Scott J., Hopkins, Bei, Horng, Joy E., Joshi, Shivangi, Marco, Eugenio, Mepani, Rina, Reyon, Deepak, Ta, Terence, Tabbaa, Diana G., Samuelsson, Steven J., Shen, Shen, Skor, Maxwell N., Stetkiewicz, Pam, Wang, Tongyao, Yudkoff, Clifford, Myer, Vic E., Albright, Charles F., Jiang, Haiyan

“…Leber congenital amaurosis type 10 is a severe retinal dystrophy caused by mutations in the CEP290 gene 1 , 2 . We developed EDIT-101, a candidate…”
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Localization of Sir2p: the nucleolus as a compartment for silent information regulators by Gotta, M, Strahl-Bolsinger, S, Renauld, H, Laroche, T, Kennedy, B.K, Grunstein, M, Gasser, S.M

“…In wild-type budding yeast strains, the proteins encoded by SIR3, SIR4 and RAP1 co-localize with telomeric DNA in a limited number of foci in interphase…”
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The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae by Gotta, M. (Swiss Institute for Experimental Cancer Research, Epalinges/Lausanne, Switzerland.), Laroche, T, Formenton, A, Maillet, L, Scherthan, H, Gasser, S.M

“…We have developed a novel technique for combined immunofluorescence/in situ hybridization on fixed budding yeast cells that maintains the three-dimensional…”
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Reactivities and selectivities of free and metal-coordinated carbocations by Mayr, Herbert, Patz, M., Gotta, M. F., Ofial, A. R.

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Distinct roles for G alpha and G beta gamma in regulating spindle position and orientation in Caenorhabditis elegans embryos by Gotta, M, Ahringer, J

“…Correct placement and orientation of the mitotic spindle is essential for segregation of localized components and positioning of daughter cells. Although these…”
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PAR-6 levels are regulated by NOS-3 in a CUL-2 dependent manner in Caenorhabditiselegans by Pacquelet, A., Zanin, E., Ashiono, C., Gotta, M.

“…The PAR proteins have an essential and conserved function in establishing polarity in many cell types and organisms. However, their key upstream regulators…”
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Analysis of nuclear organization in Saccharomyces cerevisiae by Gotta, M, Laroche, T, Gasser, S M

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Nuclear organization and transcriptional silencing in yeast by Gotta, M, Gasser, S M

“…Transcriptional repression at the yeast silent mating type loci requires the formation of a nucleoprotein complex at specific cis-acting elements called…”
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Targeting Sir proteins to sites of action: a general mechanism for regulated repression by Cockell, M, Gotta, M, Palladino, F, Martin, S G, Gasser, S M

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Systematic functional analysis of the Caenorhabditis elegans genome using RNAi by Ahringer, Julie, Kamath, Ravi S, Fraser, Andrew G, Dong, Yan, Poulin, Gino, Durbin, Richard, Gotta, Monica, Kanapin, Alexander, Le Bot, Nathalie, Moreno, Sergio, Sohrmann, Marc, Welchman, David P, Zipperlen, Peder

“…A principal challenge currently facing biologists is how to connect the complete DNA sequence of an organism to its development and behaviour. Large-scale…”
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CDC-42 controls early cell polarity and spindle orientation in C. elegans by Gotta, Monica, Abraham, Mary C., Ahringer, Julie

“…Background: Generation of asymmetry in the one-cell embryo of C. elegans establishes the anterior–posterior axis (A-P), and is necessary for the proper…”
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Synthesis, photoreactivity and fluorescence properties of new bis -9-anthryloxymethanes by Desvergne, J.P., Gotta, M., Soulignac, J.C., Lauret, J., Bouas-Laurent, H.

“…The synthesis of new coloured anthryloxymethanes is described; they are reversibly transformed upon irradiation into their colourless photocyclomers. Their…”
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At the Heart of Cell Polarity and the Cytoskeleton by Gotta, Monica

“…Researchers working on cell polarity and cytoskeletal processes met at a Keystone meeting in Coeur d’Alene, Idaho in March to present and discuss the newest…”
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Asymmetrically Distributed C. elegans Homologs of AGS3/PINS Control Spindle Position in the Early Embryo by Gotta, Monica, Dong, Yan, Peterson, Yuri K., Lanier, Stephen M., Ahringer, Julie

“…Background: Spindle positioning during an asymmetric cell division is of fundamental importance to ensure correct size of daughter cells and segregation of…”
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A Genomewide Screen for Suppressors of par-2 Uncovers Potential Regulators of PAR Protein-Dependent Cell Polarity in Caenorhabditis elegans by Labbe, Jean-Claude, Pacquelet, Anne, Marty, Thomas, Gotta, Monica

“…The PAR proteins play an essential role in establishing and maintaining cell polarity. While their function is conserved across species, little is known about…”
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Heterotrimeric G proteins and regulation of size asymmetry during cell division by Bellaiche, Yohanns, Gotta, Monica

“…The generation of daughter cells of different fate and size depends on the orientation, positioning and morphology of the mitotic spindle. In both C. elegans…”
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Nuclear organization and silencing: trafficking of Sir proteins by Gasser, S M, Gotta, M, Renauld, H, Laroche, T, Cockell, M

“…In budding yeast genes integrated near telomeres succumb to a variegated pattern of gene repression that requires the silent information regulatory proteins…”
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Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres by Laroche, Thierry, Martin, Sophie G., Gotta, Monica, Gorham, Hazel C., Pryde, Fiona E., Louis, Edward J., Gasser, Susan M.

“…The mammalian Ku70 and Ku86 proteins form a heterodimer that binds to the ends of double-stranded DNA in vitro and is required for repair of radiation-induced…”
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