Search Results - "Gotoh, Mari"

Astrocytic Neuroimmunological Roles Interacting with Microglial Cells in Neurodegenerative Diseases by Gotoh, Mari, Miyamoto, Yasunori, Ikeshima-Kataoka, Hiroko

“…Both astrocytic and microglial functions have been extensively investigated in healthy subjects and neurodegenerative diseases. For astrocytes, not only…”
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Oleic acid is a potent inducer for lipid droplet accumulation through its esterification to glycerol by diacylglycerol acyltransferase in primary cortical astrocytes by Nakajima, Shingo, Gotoh, Mari, Fukasawa, Keiko, Murakami-Murofushi, Kimiko, Kunugi, Hiroshi

“…•Oleic acid strongly induced astrocytic lipid droplet (LD) accumulation.•Lipid composition of cellular LDs reflected to extracellular fatty acids.•Inhibition…”
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Saturated fatty acid is a principal cause of anxiety-like behavior in diet-induced obese rats in relation to serum lysophosphatidyl choline level by Nakajima, Shingo, Fukasawa, Keiko, Gotoh, Mari, Murakami-Murofushi, Kimiko, Kunugi, Hiroshi

“…Background Obesity is considered to be a risk factor for neurodegenerative- and psychiatric- diseases including Alzheimer’s disease, schizophrenia, and…”
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2-carba-cyclic phosphatidic acid modulates astrocyte-to-microglia communication and influences microglial polarization towards an anti-inflammatory phenotype by Takei, Rino, Nakashima, Mari, Gotoh, Mari, Endo, Misaki, Hashimoto, Kei, Miyamoto, Yasunori, Murakami-Murofushi, Kimiko

“…[Display omitted] •Astrocyte conditioned media (2ccPA-ACM) was collected from 2ccPA-treated astrocytes.•2ccPA-ACM decreased the ratio of M1 phenotype…”
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The neuroprotective function of 2-carba-cyclic phosphatidic acid: Implications for tenascin-C via astrocytes in traumatic brain injury by Nakashima, Mari, Gotoh, Mari, Hashimoto, Kei, Endo, Misaki, Murakami-Murofushi, Kimiko, Ikeshima-Kataoka, Hiroko, Miyamoto, Yasunori

“…We examined the mechanism how 2-carba-cyclic phosphatidic acid (2ccPA), a lipid mediator, regulates neuronal apoptosis in traumatic brain injury (TBI). First,…”
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Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells by Tsukahara, Tamotsu, Sahara, Yasuka, Ribeiro, Nigel, Tsukahara, Ryoko, Gotoh, Mari, Sakamoto, Satoshi, Handa, Hiroshi, Murakami-Murofushi, Kimiko

“…Lipid-protein interactions play essential roles in many biological phenomena. Lysophospholipid mediators, such as cyclic phosphatidic acid (cPA), have been…”
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Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease by Yamamoto, Shinji, Yamashina, Kota, Ishikawa, Masaki, Gotoh, Mari, Yagishita, Sosuke, Iwasa, Kensuke, Maruyama, Kei, Murakami-Murofushi, Kimiko, Yoshikawa, Keisuke

“…Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive…”
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2-O-Carba-oleoyl cyclic phosphatidic acid induces glial proliferation through the activation of lysophosphatidic acid receptor by Nakajima, Shingo, Gotoh, Mari, Fukasawa, Keiko, Murofushi, Hiromu, Murakami-Murofushi, Kimiko

“…•2ccPA increased glial cell proliferation through the activation of LPA receptor.•2ccPA treatment enhanced cell survival against oxidative stress.•ERK pathway…”
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2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition by Fukasawa, Keiko, Gotoh, Mari, Uwamizu, Akiharu, Hirokawa, Takatsugu, Ishikawa, Masaki, Shimizu, Yoshibumi, Yamamoto, Shinji, Iwasa, Kensuke, Yoshikawa, Keisuke, Aoki, Junken, Murakami-Murofushi, Kimiko

“…Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator that, along with its chemically stabilized analogue 2-carba-cyclic phosphatidic…”
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Cyclic phosphatidic acid and lysophosphatidic acid induce hyaluronic acid synthesis via CREB transcription factor regulation in human skin fibroblasts by Maeda-Sano, Katsura, Gotoh, Mari, Morohoshi, Toshiro, Someya, Takao, Murofushi, Hiromu, Murakami-Murofushi, Kimiko

“…Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator and an analog of the growth factor-like phospholipid lysophosphatidic acid (LPA)…”
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Protection of neuroblastoma Neuro2A cells from hypoxia-induced apoptosis by cyclic phosphatidic acid (cPA) by Gotoh, Mari, Sano-Maeda, Katsura, Murofushi, Hiromu, Murakami-Murofushi, Kimiko

“…Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator with a unique cyclic phosphate ring at the sn-2 and sn-3 positions of its…”
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LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model by Tsukahara, Ryoko, Yamamoto, Shinji, Yoshikawa, Keisuke, Gotoh, Mari, Tsukahara, Tamotsu, Neyama, Hiroyuki, Ishii, Satoshi, Akahoshi, Noriyuki, Yanagida, Keisuke, Sumida, Hayakazu, Araki, Masatake, Araki, Kimi, Yamamura, Ken-ichi, Murakami-Murofushi, Kimiko, Ueda, Hiroshi

“…Lysophosphatidic acid (LPA) and LPA1 receptor signaling play a crucial role in the initiation of peripheral nerve injury-induced neuropathic pain through the…”
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Quantitative determination of cyclic phosphatidic acid and its carba analog in mouse organs and plasma using LC–MS/MS by Shimizu, Yoshibumi, Ishikawa, Masaki, Gotoh, Mari, Fukasawa, Keiko, Yamamoto, Shinji, Iwasa, Kensuke, Yoshikawa, Keisuke, Murakami-Murofushi, Kimiko

“…Cyclic phosphatidic acid (cPA), an analog of lysophosphatidic acid, is involved in the regulation of many cellular processes. A sensitive and specific method…”
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Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis by Gotoh, Mari, Fujiwara, Yuko, Yue, Junming, Liu, Jianxiong, Lee, SueChin, Fells, James, Uchiyama, Ayako, Murakami-Murofushi, Kimiko, Kennel, Stephen, Wall, Jonathan, Patil, Renukadevi, Gupte, Renuka, Balazs, Louisa, Miller, Duane D, Tigyi, Gabor J

“…LPA (lysophosphatidic acid, 1-acyl-2-hydroxy-sn-glycero-3-phosphate), is a growth factor-like lipid mediator that regulates many cellular functions, many of…”
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Cyclic phosphatidic acid treatment suppress cuprizone-induced demyelination and motor dysfunction in mice by Yamamoto, Shinji, Gotoh, Mari, Kawamura, Yuuki, Yamashina, Kota, Yagishita, Sosuke, Awaji, Takeo, Tanaka, Motomu, Maruyama, Kei, Murakami-Murofushi, Kimiko, Yoshikawa, Keisuke

“…Multiple sclerosis is a chronic demyelinating disease of the central nervous system leading to progressive cognitive and motor dysfunction, which is…”
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Evaluation of the pharmacokinetics of 2-carba-cyclic phosphatidic acid by liquid chromatography-triple quadrupole mass spectrometry by Shimizu, Yoshibumi, Fukasawa, Keiko, Yamamoto, Shinji, Shibaike, Yuki, Tsukahara, Ryoko, Ishikawa, Masaki, Iwasa, Kensuke, Yoshikawa, Keisuke, Gotoh, Mari, Murakami-Murofushi, Kimiko

“…•Intraperitoneally administrated 2ccPA distributed whole body in mouse.•2ccPA decreased LPA concentration in mouse or rat plasma.•Orally administrated 2ccPA…”
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The effect of cyclic phosphatidic acid on the proliferation and differentiation of mouse cerebellar granule precursor cells during cerebellar development by Konakazawa, Misa, Gotoh, Mari, Murakami-Murofushi, Kimiko, Hamano, Ayana, Miyamoto, Yasunori

“…Abstract The proliferation and differentiation of cerebellar granule cell precursors (GCPs) are highly regulated spatiotemporally during development. We…”
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Age-related changes in cyclic phosphatidic acid-induced hyaluronic acid synthesis in human fibroblasts by Sano, Katsura, Gotoh, Mari, Dodo, Kyoko, Tajima, Noriaki, Shimizu, Yoshibumi, Murakami-Murofushi, Kimiko

“…Hyaluronic acid is a major component of the extracellular matrix, which is important for skin hydration. As aging brings skin dehydration, we aimed to clarify…”
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Effects of cyclic phosphatidic acid on delayed neuronal death following transient ischemia in rat hippocampal CA1 by Gotoh, Mari, Hotta, Harumi, Murakami-Murofushi, Kimiko

“…Cyclic phosphatidic acid (cPA) is a lipid mediator that elicits a neurotrophin-like action in embryonic hippocampal neurons in vitro. In this study, we…”
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Correction to: Protective and therapeutic role of 2-carbacyclic phosphatidic acid in demyelinating disease by Yamamoto, Shinji, Yamashina, Kota, Ishikawa, Masaki, Gotoh, Mari, Yagishita, Sosuke, Iwasa, Kensuke, Maruyama, Kei, Murakami-Murofushi, Kimiko, Yoshikawa, Keisuke

“…After publication of the article [1], it was brought to our attention that an acknowledgement was missing from the original version…”
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