Search Results - "Goto, Megumi"

G Protein-Coupled Receptor 39 Agonist Improves Concanavalin A-Induced Hepatitis in Mice by Muneoka, Satoshi, Goto, Megumi, Nishimura, Tomonari, Enomoto, Kei, Kadoshima-Yamaoka, Kumiko, Tomimori, Yoshiaki

“…The protective effects of G protein-coupled receptor 39 (GPR39) on concanavalin A (Con A)-induced hepatitis in mice was examined. In a dose dependent manner…”
Get full text

G protein-coupled receptor 39 plays an anti-inflammatory role by enhancing IL-10 production from macrophages under inflammatory conditions by Muneoka, Satoshi, Goto, Megumi, Kadoshima-Yamaoka, Kumiko, Kamei, Reiko, Terakawa, Maki, Tomimori, Yoshiaki

“…The possible role of G protein-coupled receptor 39 (GPR39) in inflammation was examined in macrophages. Gpr39 expression increased in thioglycollate-induced…”
Get full text

Association of serum thyroid hormone levels with positron emission tomography imaging in non‐demented older adults by Goto, Megumi, Kimura, Noriyuki, Matsubara, Etsuro

“…Background Background Although increasing evidence indicates that even variations in normal range thyroid function are associated with Alzheimer's disease…”
Get full text

Discovery and structure–activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors by Murafuji, Hidenobu, Sakai, Hiroki, Goto, Megumi, Imajo, Seiichi, Sugawara, Hajime, Muto, Tsuyoshi

“…[Display omitted] Compound 1, composed of a 1,3,6-trisubstituted 1,4-diazepane-7-one, was discovered as a novel human kallikrein 7 (KLK7, stratum corneum…”
Get full text

A new immunodeficient Duchenne muscular dystrophy rat model to evaluate engraftment after human cell transplantation by Sato, Masae, Goto, Megumi, Yamanouchi, Keitaro, Sakurai, Hidetoshi

“…Duchenne muscular dystrophy (DMD) is an X-linked fatal muscular disease, affecting one in 3,500 live male births worldwide. Currently, there is no cure for…”
Get full text

Discovery and structure-activity relationship of imidazolinylindole derivatives as kallikrein 7 inhibitors by Murafuji, Hidenobu, Muto, Tsuyoshi, Goto, Megumi, Imajo, Seiichi, Sugawara, Hajime, Oyama, Yoshiaki, Minamitsuji, Yutaka, Miyazaki, Shuji, Murai, Kenichi, Fujioka, Hiromichi

“…[Display omitted] •Novel imidazolinylindole derivatives as KLK7 inhibitor are disclosed, and their SAR is discussed.•The position of substituent on the…”
Get full text

Cell transplantation-mediated dystrophin supplementation efficacy in Duchenne muscular dystrophy mouse motor function improvement demonstrated by enhanced skeletal muscle fatigue tolerance by Bourgeois Yoshioka, Clémence Kiho, Takenaka-Ninagawa, Nana, Goto, Megumi, Miki, Mayuho, Watanabe, Daiki, Yamamoto, Masamichi, Aoyama, Tomoki, Sakurai, Hidetoshi

“…Duchenne muscular dystrophy (DMD) is an incurable neuromuscular disease leading to progressive skeletal muscle weakness and fatigue. Cell transplantation in…”
Get full text

Critical amino acid variants in HLA-DRB1 allotypes in the development of Graves’ disease and Hashimoto’s thyroiditis in the Japanese population by Katahira, Masahito, Ogata, Hidetada, Takashima, Hiromi, Ito, Takahiro, Hodai, Yuichi, Miwata, Tsutomu, Goto, Megumi, Yamaguchi, Mariko, Mizoguchi, Akira, Kawakubo, Mitsuhiro, Nakamura, Shizuka

“…The effects of amino acid variants encoded by human leukocyte antigen (HLA) class II on the development of Graves’ disease (GD) and Hashimoto’s thyroiditis…”
Get full text

Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones by Murafuji, Hidenobu, Sugawara, Hajime, Goto, Megumi, Oyama, Yoshiaki, Sakai, Hiroki, Imajo, Seiichi, Tomoo, Toshiyuki, Muto, Tsuyoshi

“…[Display omitted] A series of 1,3,6-trisubstituted 1,4-diazepan-7-ones were prepared as kallikrein 7 (KLK7, stratum corneum chymotryptic enzyme) inhibitors…”
Get full text

Structure-based drug design of 1,3,6-trisubstituted 1,4-diazepan-7-ones as selective human kallikrein 7 inhibitors by Murafuji, Hidenobu, Sakai, Hiroki, Goto, Megumi, Oyama, Yoshiaki, Imajo, Seiichi, Sugawara, Hajime, Tomoo, Toshiyuki, Muto, Tsuyoshi

“…[Display omitted] A novel series of 1,3,6-trisubstituted 1,4-diazepan-7-ones were investigated as human kallikrein 7 (KLK7, stratum corneum chymotryptic…”
Get full text

Collagen-VI supplementation by cell transplantation improves muscle regeneration in Ullrich congenital muscular dystrophy model mice by Takenaka-Ninagawa, Nana, Kim, Jinsol, Zhao, Mingming, Sato, Masae, Jonouchi, Tatsuya, Goto, Megumi, Yoshioka, Clémence Kiho Bourgeois, Ikeda, Rukia, Harada, Aya, Sato, Takahiko, Ikeya, Makoto, Uezumi, Akiyoshi, Nakatani, Masashi, Noguchi, Satoru, Sakurai, Hidetoshi

“…Background Mesenchymal stromal cells (MSCs) function as supportive cells on skeletal muscle homeostasis through several secretory factors including type 6…”
Get full text

Systemic Supplementation of Collagen VI by Neonatal Transplantation of iPSC-Derived MSCs Improves Histological Phenotype and Function of Col6-Deficient Model Mice by Harada, Aya, Goto, Megumi, Kato, Atsuya, Takenaka-Ninagawa, Nana, Tanaka, Akito, Noguchi, Satoru, Ikeya, Makoto, Sakurai, Hidetoshi

“…Collagen VI is distributed in the interstitium and is secreted mainly by mesenchymal stromal cells (MSCs) in skeletal muscle. Mutations in COL6A1-3 genes cause…”
Get full text

An Outbreak of Canine Distemper Virus in Tigers (Panthera tigris): Possible Transmission from Wild Animals to Zoo Animals by NAGAO, Yumiko, NISHIO, Yohei, SHIOMODA, Hiroshi, TAMARU, Seiji, SHIMOJIMA, Masayuki, GOTO, Megumi, UNE, Yumi, SATO, Azusa, IKEBE, Yusuke, MAEDA, Ken

“…Canine distemper virus (CDV), a morbillivirus that causes one of the most contagious and lethal viral diseases known in canids, has an expanding host range,…”
Get full text

Association of Autoimmune Thyroid Disease with Anti-GAD Antibody ELISA Test Positivity and Risk for Insulin Deficiency in Slowly Progressive Type 1 Diabetes by Takashima, Hiromi, Goto, Megumi, Miwata, Tsutomu, Ito, Takahiro, Ogata, Hidetada, Katahira, Masahito, Nakamura, Shizuka

“…The presence of antiglutamic acid decarboxylase antibody (GADA) is required for the diagnosis of slowly progressive type 1 diabetes (SPT1D). We examined the…”
Get full text

Japanese soup stocks (katsuo-dashi and kombu-dashi) modulate food factor sensing-related gene expression in mice by Murata, Motoki, Nakayama, Kai, Kitamura, Ryo, Goto, Megumi, Morozumi, Mai, Yoshimoto, Takanori, Marugame, Yuki, Yoshitomi, Ren, Yamashita, Shuya, Fujimura, Yoshinori, Tachibana, Hirofumi

“…Food factors, such as amino acids, vitamins, and polyphenols, have been reported to exert biological effects through a system that senses food factors…”
Get full text

Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils by Terakawa, Maki, Tomimori, Yoshiaki, Goto, Megumi, Fukuda, Yoshiaki

“…Human chymase induced release of interleukin-8 (IL-8) in human EoL-1 cells that had been differentiated into eosinophil-like cells with butyric acid. The…”
Get full text

Brain Perfusion in Corticobasal Syndrome with Progressive Aphasia by Abe, Yoshitake, Kimura, Noriyuki, Goto, Megumi, Aso, Yasuhiro, Matsubara, Etsuro

“…Background: Brain perfusion may differ between patients with corticobasal syndrome (CBS) with and without aphasia. Methods: Twenty-six (9 males and 17 females;…”
Get full text

Distinct muscle regenerative capacity of human induced pluripotent stem cell-derived mesenchymal stromal cells in Ullrich congenital muscular dystrophy model mice by Yokomizo-Goto, Megumi, Takenaka-Ninagawa, Nana, Zhao, Chengzhu, Bourgeois Yoshioka, Clémence Kiho, Miki, Mayuho, Motoike, Souta, Inada, Yoshiko, Zujur, Denise, Theoputra, William, Jin, Yonghui, Toguchida, Junya, Ikeya, Makoto, Sakurai, Hidetoshi

“…Ullrich congenital muscular dystrophy (UCMD) is caused by a deficiency in type 6 collagen (COL6) due to mutations in COL6A1, COL6A2, or COL6A3. COL6 deficiency…”
Get full text

Characteristics of H- and M-waves recorded from rat forelimbs by Hosoido, Taisei, Motoyama, Sachiko, Goto, Megumi, Mori, Futoshi, Tajima, Takamitsu, Hirata, Hajime, Wada, Naomi

“…The Hoffman reflex (H-reflex) is a useful tool for studying the functional aspects of the spinal cord without anesthesia and/or damage to the body. H-reflex…”
Get full text

Post Treatment With an FGF Chimeric Growth Factor Enhances Epithelial Cell Proliferation to Improve Recovery From Radiation-Induced Intestinal Damage by Nakayama, Fumiaki, M.D., Ph.D, Hagiwara, Akiko, B.S, Umeda, Sachiko, B.S, Asada, Masahiro, Ph.D, Goto, Megumi, M.S, Oki, Junko, M.S, Suzuki, Masashi, Ph.D, Imamura, Toru, Ph.D, Akashi, Makoto, M.D., Ph.D

“…Purpose A fibroblast growth factor (FGF) 1–FGF2 chimera (FGFC) was created previously and showed greater structural stability than FGF1. This chimera was…”
Get full text