Search Results - "Goto, Chisato"

Bone Morphogenetic Protein 4 and Smad1 Mediate Extracellular Matrix Production in the Development of Diabetic Nephropathy by Matsubara, Takeshi, Araki, Makoto, Abe, Hideharu, Ueda, Otoya, Jishage, Kou-ichi, Mima, Akira, Goto, Chisato, Tominaga, Tatsuya, Kinosaki, Masahiko, Kishi, Seiji, Nagai, Kojiro, Iehara, Noriyuki, Fukushima, Naoshi, Kita, Toru, Arai, Hidenori, Doi, Toshio

“…Diabetic nephropathy is the leading cause of end-stage renal disease. It is pathologically characterized by the accumulation of extracellular matrix in the…”
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SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose by Fukuzawa, Taku, Fukazawa, Masanori, Ueda, Otoya, Shimada, Hideaki, Kito, Aki, Kakefuda, Mami, Kawase, Yosuke, Wada, Naoko A, Goto, Chisato, Fukushima, Naoshi, Jishage, Kou-Ichi, Honda, Kiyofumi, King, George L, Kawabe, Yoshiki

“…Although excessive fructose intake is epidemiologically linked with dyslipidemia, obesity, and diabetes, the mechanisms regulating plasma fructose are not well…”
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Novel genetically-humanized mouse model established to evaluate efficacy of therapeutic agents to human interleukin-6 receptor by Ueda, Otoya, Tateishi, Hiromi, Higuchi, Yoshinobu, Fujii, Etsuko, Kato, Atsuhiko, Kawase, Yosuke, Wada, Naoko A., Tachibe, Takanori, Kakefuda, Mami, Goto, Chisato, Kawaharada, Makoto, Shimaoka, Shin, Hattori, Kunihiro, Jishage, Kou-ichi

“…For clinical trials of therapeutic monoclonal antibodies (mAbs) to be successful, their efficacy needs to be adequately evaluated in preclinical experiments…”
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Activation of Bone Morphogenetic Protein 4 Signaling Leads to Glomerulosclerosis That Mimics Diabetic Nephropathy by Tominaga, Tatsuya, Abe, Hideharu, Ueda, Otoya, Goto, Chisato, Nakahara, Kunihiko, Murakami, Taichi, Matsubara, Takeshi, Mima, Akira, Nagai, Kojiro, Araoka, Toshikazu, Kishi, Seiji, Fukushima, Naoshi, Jishage, Kou-ichi, Doi, Toshio

“…Diabetic nephropathy (DN) is the most common cause of chronic kidney disease. We have previously reported that Smad1 transcriptionally regulates the expression…”
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Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3–mediated therapeutics by Ueda, Otoya, Wada, Naoko A., Kinoshita, Yasuko, Hino, Hiroshi, Kakefuda, Mami, Ito, Tsuneo, Fujii, Etsuko, Noguchi, Mizuho, Sato, Kiyoharu, Morita, Masahiro, Tateishi, Hiromi, Matsumoto, Kaoru, Goto, Chisato, Kawase, Yosuke, Kato, Atsuhiko, Hattori, Kunihiro, Nezu, Junichi, Ishiguro, Takahiro, Jishage, Kou-ichi

“…T cell–mediated immunotherapy is an attractive strategy for treatment in various disease areas. In this therapeutic approach, the CD3 complex is one of the key…”
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Correction: Corrigendum: Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3–mediated therapeutics by Ueda, Otoya, Wada, Naoko A., Kinoshita, Yasuko, Hino, Hiroshi, Kakefuda, Mami, Ito, Tsuneo, Fujii, Etsuko, Noguchi, Mizuho, Sato, Kiyoharu, Morita, Masahiro, Tateishi, Hiromi, Matsumoto, Kaoru, Goto, Chisato, Kawase, Yosuke, Kato, Atsuhiko, Hattori, Kunihiro, Nezu, Junichi, Ishiguro, Takahiro, Jishage, Kou-ichi

“…Correction to: Scientific Reports 7: Article number: 45839; published online: 03 April 2017; updated: 19 March 2018 In this Article, the Authors neglected to…”
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Corrigendum: Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3-mediated therapeutics by Ueda, Otoya, Wada, Naoko A, Kinoshita, Yasuko, Hino, Hiroshi, Kakefuda, Mami, Ito, Tsuneo, Fujii, Etsuko, Noguchi, Mizuho, Sato, Kiyoharu, Morita, Masahiro, Tateishi, Hiromi, Matsumoto, Kaoru, Goto, Chisato, Kawase, Yosuke, Kato, Atsuhiko, Hattori, Kunihiro, Nezu, Junichi, Ishiguro, Takahiro, Jishage, Kou-Ichi

“…This corrects the article DOI: 10.1038/srep45839…”
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Entire CD3[epsilon], [delta], and [gamma] humanized mouse to evaluate human CD3-mediated therapeutics by Ueda, Otoya, Wada, Naoko A, Kinoshita, Yasuko, Hino, Hiroshi, Kakefuda, Mami, Ito, Tsuneo, Fujii, Etsuko, Noguchi, Mizuho, Sato, Kiyoharu, Morita, Masahiro, Tateishi, Hiromi, Matsumoto, Kaoru, Goto, Chisato, Kawase, Yosuke, Kato, Atsuhiko, Hattori, Kunihiro, Nezu, Junichi, Ishiguro, Takahiro, Jishage, Kou-ichi

“…T cell-mediated immunotherapy is an attractive strategy for treatment in various disease areas. In this therapeutic approach, the CD3 complex is one of the key…”
Get full text