Search Results - "Gotfredsen, Carsten"

Glucagon-Like Peptide-1 Receptor Agonists Activate Rodent Thyroid C-Cells Causing Calcitonin Release and C-Cell Proliferation by Bjerre Knudsen, Lotte, Madsen, Lars Wichmann, Andersen, Søren, Almholt, Kasper, de Boer, Anne S, Drucker, Daniel J, Gotfredsen, Carsten, Egerod, Frederikke Lihme, Hegelund, Anne Charlotte, Jacobsen, Helene, Jacobsen, Søren Dyring, Moses, Alan C, Mølck, Anne-Marie, Nielsen, Henriette S, Nowak, Jette, Solberg, Helene, Thi, Tu D. L, Zdravkovic, Milan

“…Liraglutide is a glucagon-like peptide-1 (GLP-1) analog developed for type 2 diabetes. Long-term liraglutide exposure in rodents was associated with thyroid…”
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Liraglutide, a Long-Acting Glucagon-Like Peptide-1 Analog, Reduces Body Weight and Food Intake in Obese Candy-Fed Rats, Whereas a Dipeptidyl Peptidase-IV Inhibitor, Vildagliptin, Does Not by RAUN, Kirsten, VON VOSS, Pia, GOTFREDSEN, Carsten F, GOLOZOUBOVA, Valeria, ROLIN, Bidda, KNUDSEN, Lotte Bjerre

“…Liraglutide, a Long-Acting Glucagon-Like Peptide-1 Analog, Reduces Body Weight and Food Intake in Obese Candy-Fed Rats, Whereas a Dipeptidyl Peptidase-IV…”
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The Human GLP-1 Analogs Liraglutide and Semaglutide: Absence of Histopathological Effects on the Pancreas in Nonhuman Primates by GOTFREDSEN, Carsten F, MØLCK, Anne-Marie, THORUP, Inger, BERG NYBORG, Niels C, SALANTI, Zaki, KNUDSEN, Lotte Bjerre, LARSEN, Marianne O

“…Increased pancreas mass and glucagon-positive adenomas have been suggested to be a risk associated with sitagliptin or exenatide therapy in humans. Novo…”
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Long-Term AICAR Administration and Exercise Prevents Diabetes in ZDF Rats by POLD, Rasmus, JENSEN, Lasse S, LAND, Sten, JESSEN, Niels, BUHL, Esben S, SCHMITZ, Ole, FLYVBJERG, Allan, FUJII, Nobuharu, GOODYEAR, Laurie J, GOTFREDSEN, Carsten F, BRAND, Christian L

“…Long-Term AICAR Administration and Exercise Prevents Diabetes in ZDF Rats Rasmus Pold 1 , Lasse S. Jensen 1 , Niels Jessen 1 , Esben S. Buhl 1 , Ole Schmitz 1…”
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The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice by Rolin, Bidda, Larsen, Marianne O, Gotfredsen, Carsten F, Deacon, Carolyn F, Carr, Richard D, Wilken, Michael, Knudsen, Lotte Bjerre

“…NN2211 is a long-acting, metabolically stable glucagon-like peptide-1 (GLP-1) derivative designed for once daily administration in humans. NN2211 dose…”
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GLP‐1 derivative liraglutide in rats with β‐cell deficiencies: influence of metabolic state on β‐cell mass dynamics by Sturis, Jeppe, Gotfredsen, Carsten F, Rømer, John, Rolin, Bidda, Ribel, Ulla, Brand, Christian L, Wilken, Michael, Wassermann, Karsten, Deacon, Carolyn F, Carr, Richard D, Knudsen, Lotte Bjerre

“…Liraglutide is a long‐acting GLP‐1 derivative, designed for once daily administration in type II diabetic patients. To investigate the effects of liraglutide…”
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Improved insulin sensitivity and islet function after PPARδ activation in diabetic db/db mice by Winzell, Maria Sörhede, Wulff, Erik Max, Olsen, Grith Skytte, Sauerberg, Per, Gotfredsen, Carsten F., Ahrén, Bo

“…The peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to the nuclear receptor superfamily. Several reports have shown…”
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TRPV1 Antagonists as Novel Anti-Diabetic Agents: Regulation of Oral Glucose Tolerance and Insulin Secretion Through Reduction of Low-Grade Inflammation? by Gram, Dorte X, Fribo, Josefine, Nagy, Istvan, Gotfredsen, Carsten, Charrua, Ana, Hansen, John B, Hansen, Anker J, Szallasi, Arpad

“…With a global prevalence among adults over 18 years of age approaching 9%, Type 2 diabetes mellitus (T2DM) has reached pandemic proportions and represents a…”
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Mild streptozotocin diabetes in the Göttingen minipig. A novel model of moderate insulin deficiency and diabetes by Larsen, Marianne O, Wilken, Michael, Gotfredsen, Carsten F, Carr, Richard D, Svendsen, Ove, Rolin, Bidda

“…Nonrodent models of diabetes are needed for practical and physiological reasons. Induction of mild insulin-deficient diabetes was investigated in male…”
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Measurements of Insulin Secretory Capacity and Glucose Tolerance to Predict Pancreatic β-Cell Mass In Vivo in the Nicotinamide/Streptozotocin Göttingen Minipig, a Model of Moderate Insulin Deficiency and Diabetes by LARSEN, Marianne O, ROLIN, Bidda, WILKEN, Michael, CARR, Richard D, GOTFREDSEN, Carsten F

“…Measurements of Insulin Secretory Capacity and Glucose Tolerance to Predict Pancreatic β-Cell Mass In Vivo in the Nicotinamide/Streptozotocin Göttingen…”
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Liraglutide, but not vildagliptin, restores normoglycaemia and insulin content in the animal model of type 2 diabetes, Psammomys obesus by Vedtofte, Louise, Bodvarsdottir, Thóra B., Gotfredsen, Carsten F., Karlsen, Allan E., Knudsen, Lotte B., Heller, R. Scott

“…In order to investigate the effect and mechanism of liraglutide and vildagliptin in diabetic Psammomys obesus, we examined proliferation and apoptosis of…”
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Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective KATP Channel Opener by SKAK, Kresten, GOTFREDSEN, Carsten F, LUNDSGAARD, Dorthe, HANSEN, John Bondo, STURIS, Jeppe, MARKHOLST, Helle

“…Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective K ATP Channel Opener Kresten Skak 1 ,…”
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Measurements of insulin responses as predictive markers of pancreatic beta-cell mass in normal and beta-cell-reduced lean and obese Göttingen minipigs in vivo by Larsen, Marianne O, Rolin, Bidda, Sturis, Jeppe, Wilken, Michael, Carr, Richard D, Pørksen, Niels, Gotfredsen, Carsten F

“…At present, the best available estimators of beta-cell mass in humans are those based on measurement of insulin levels or appearance rates in the circulation…”
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Valine pyrrolidide preserves intact glucose-dependent insulinotropic peptide and improves abnormal glucose tolerance in minipigs with reduced beta-cell mass by Larsen, Marianne Olholm, Rolin, Bidda, Ribel, Ulla, Wilken, Michael, Deacon, Carolyn F, Svendsen, Ove, Gotfredsen, Carsten F, Carr, Richard David

“…The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are important in blood glucose regulation…”
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Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K+ channels and stimulation of cyclic AMP-dependent exocytosis by GROMADA, Jesper, BOKVIST, Krister, HØY, Marianne, OLSEN, Hervor L, LINDSTRÖM, Per, HANSEN, Birgit S, GOTFREDSEN, Carsten F, RORSMAN, Patrik, THOMSEN, Mads Krogsgaard

“…GH causes insulin resistance, impairs glycemic control and increases the risk of vascular diabetic complications. Sulphonylureas stimulate GH secretion and…”
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The kidney myeloid cell compartment is perturbed in diabetic BTBR ob/ob mice (INC6P.338) by Fink, Lisbeth, Gotfredsen, Carsten, Rosendahl, Alexander, Pedersen, Maiken

“…Abstract The BTBR ob/ob mouse is gaining interest as a model of diabetic nephropathy, because it develops progressive albuminuria and, as opposed to the db/db…”
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GLP-1 Receptor Agonists and the Thyroid: C-Cell Effects in Mice Are Mediated via the GLP-1 Receptor and not Associated with RET Activation by Madsen, Lars Wichmann, Knauf, Jeffrey A, Gotfredsen, Carsten, Pilling, Andrew, Sjögren, Ingrid, Andersen, Søren, Andersen, Lene, Sietske de Boer, Anne, Manova, Katia, Barlas, Afsar, Vundavalli, Sushil, Nyborg, Niels C. Berg, Bjerre Knudsen, Lotte, Moelck, Anne Marie, Fagin, James A

“…Liraglutide and exenatide are glucagon-like peptide receptor (GLP-1R) agonists used in the treatment of type 2 diabetes. Both molecules have been associated…”
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Abstract 467: The ApoA-1 Mimetic Peptide D-4F Shows Antidiabetic Efficacy In db/db Mice Only After Intraperitoneal Administration by Rolin, Bidda, Kirk, Rikke K, Gotfredsen, Carsten, Bjerring, Barbara H, Klitgaard, Thomas, Kodra, Janos T, Mohr, Malene, Rasmussen, Salka E

“…Abstract only Objective: The apoA-I mimetic peptide L-4F has previously been shown to have antidiabetic efficacy in ob/ob mice. In this study we tested the…”
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Glucagon-Like Peptide-1 Receptor Agonists Activate Rodent Thyroid C-Cells Causing Calcitonin Release and C-Cell Proliferation by Knudsen, Lotte Bjerre, Madsen, Lars Wichmann, Andersen, Søren, Almholt, Kasper, de Boer, Anne S, Drucker, Daniel J, Gotfredsen, Carsten, Egerod, Frederikke Lihme, Hegelund, Anne Charlotte, Jacobsen, Helene, Jacobsen, Søren Dyring, Moses, Alan C, Mølck, Anne Marie, Nielsen, Henriette S, Nowak, Jette, Solberg, Helene, Thi, Tu D. L, Zdravkovic, Milan

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Improved [beta]-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a [beta]-Cell-Selective K^sub ATP^ Channel Opener by Skak, Kresten, Gotfredsen, Carsten F, Lundsgaard, Dorthe, Hansen, John Bondo

“…Treatment with ATP-sensitive K(+) channel openers (KCOs) leads to inhibition of insulin secretion and metabolic "rest" in beta-cells. It is hypothesized that…”
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