Search Results - "Gossye, Valerie"
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Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation
Published in PloS one (30-07-2013)“…Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF-κB-mediated…”
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An anti‐inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation
Published in The FASEB journal (01-04-2011)“…ABSTRACT Glucocorticoids (GCs) are in widespread use to treat inflammatory bone diseases, such as rheumatoid arthritis (RA). Their anti‐inflammatory efficacy,…”
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A Plant-Derived Ligand Favoring Monomeric Glucocorticoid Receptor Conformation with Impaired Transactivation Potential Attenuates Collagen-Induced Arthritis
Published in The Journal of immunology (1950) (15-02-2008)“…The glucocorticoid receptor (GR) is a transcription factor regulating its target genes either positively, through direct binding to the promoter of target…”
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Therapeutic implications of the nuclear factor-kappaB/nuclear receptor cross-talk
Published in Frontiers in bioscience (01-05-2008)“…More and more evidence reveals that the transcription factor NF-kappaB plays a critical role in tumor development and progression and that it may constitute…”
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Correction: Compound A, a Selective Glucocorticoid Receptor Modulator, Enhances Heat Shock Protein Hsp70 Gene Promoter Activation
Published in PloS one (01-10-2013)Get full text
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Compound A, a Selective Glucocorticoid Receptor Modulator, Enhances Heat Shock Protein Hsp70 Gene Promoter Activation. e69115
Published in PloS one (01-07-2013)“…Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF- Kappa…”
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Differential mechanism of NF‐κB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts
Published in Arthritis and rheumatism (01-11-2009)“…Objective To investigate and compare the molecular mechanisms by which 2 glucocorticoid receptor (GR)–activating compounds, dexamethasone (DEX) and Compound A…”
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Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts
Published in Arthritis and rheumatism (01-11-2009)“…To investigate and compare the molecular mechanisms by which 2 glucocorticoid receptor (GR)-activating compounds, dexamethasone (DEX) and Compound A (CpdA),…”
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