Search Results - "Goss, Rebecca J. M"

Antiviral drug discovery: preparing for the next pandemic by Adamson, Catherine S, Chibale, Kelly, Goss, Rebecca J M, Jaspars, Marcel, Newman, David J, Dorrington, Rosemary A

“…Clinically approved antiviral drugs are currently available for only 10 of the more than 220 viruses known to infect humans. The SARS-CoV-2 outbreak has…”
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Antimicrobial nucleoside antibiotics targeting cell wall assembly: recent advances in structure-function studies and nucleoside biosynthesis by Winn, Michael, Goss, Rebecca J M, Kimura, Ken-ichi, Bugg, Timothy D H

“…The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed…”
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A single Streptomyces symbiont makes multiple antifungals to support the fungus farming ant Acromyrmex octospinosus by Seipke, Ryan F, Barke, Jörg, Brearley, Charles, Hill, Lionel, Yu, Douglas W, Goss, Rebecca J M, Hutchings, Matthew I

“…Attine ants are dependent on a cultivated fungus for food and use antibiotics produced by symbiotic Actinobacteria as weedkillers in their fungus gardens…”
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Gene Expression Enabling Synthetic Diversification of Natural Products: Chemogenetic Generation of Pacidamycin Analogs by Roy, Abhijeet Deb, Grüschow, Sabine, Cairns, Nickiwe, Goss, Rebecca J. M

“…Introduction of prnA, the halogenase gene from pyrrolnitrin biosynthesis, into Streptomyces coeruleorubidus resulted in efficient in situ chlorination of the…”
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The generation of "unnatural" products: synthetic biology meets synthetic chemistry by Goss, Rebecca J M, Shankar, Sreejith, Fayad, Antoine Abou

“…Natural product analogue generation is important, providing tools for chemical biology, enabling structure activity relationship determination and insight into…”
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A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus by Barke, Jörg, Seipke, Ryan F, Grüschow, Sabine, Heavens, Darren, Drou, Nizar, Bibb, Mervyn J, Goss, Rebecca J M, Yu, Douglas W, Hutchings, Matthew I

“…Attine ants live in an intensely studied tripartite mutualism with the fungus Leucoagaricus gongylophorus, which provides food to the ants, and with…”
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The First One-Pot Synthesis of l‑7-Iodotryptophan from 7‑Iodoindole and Serine, and an Improved Synthesis of Other l‑7-Halotryptophans by Smith, Duncan R. M, Willemse, Tom, Gkotsi, Danai S, Schepens, Wim, Maes, Bert U. W, Ballet, Steven, Goss, Rebecca J. M

“…A simple and scalable one-pot biotransformation enables direct access to l-halotryptophans, including l-7-iodotryptophan, from the corresponding haloindoles…”
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The Impact of Viral Infection on the Chemistries of the Earth's Most Abundant Photosynthesizes: Metabolically Talented Aquatic Cyanobacteria by Wang, Yunpeng, Ferrinho, Scarlet, Connaris, Helen, Goss, Rebecca J M

“…Cyanobacteria are the most abundant photosynthesizers on earth, and as such, they play a central role in marine metabolite generation, ocean nutrient cycling,…”
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Halogenases: a palette of emerging opportunities for synthetic biology-synthetic chemistry and C-H functionalisation by Crowe, Charlotte, Molyneux, Samuel, Sharma, Sunil V, Zhang, Ying, Gkotsi, Danai S, Connaris, Helen, Goss, Rebecca J M

“…The enzymatic generation of carbon-halogen bonds is a powerful strategy used by both nature and synthetic chemists to tune the bioactivity, bioavailability and…”
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The Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Antibiotic and Anticancer Agent Marinomycin by Abraham, Emily, Lawther, Hannah A, Wang, Yunpeng, Zarins-Tutt, Joseph S, Rivera, Gerry Sann, Wu, Chengcang, Connolly, Jack A, Florence, Gordon, Agbo, Matthias, Gao, Hong, Goss, Rebecca J M

“…With the rise in antimicrobial resistance, there is an urgent need for new classes of antibiotic with which to treat infectious disease. Marinomycin, a polyene…”
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Scope and potential of halogenases in biosynthetic applications by Smith, Duncan RM, Grüschow, Sabine, Goss, Rebecca JM

“…► Halogenated natural products are diverse in structure, activity, and biosynthesis. ► Halogenases can show high regioselectivity that is often difficult to…”
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Mechanism of action of the uridyl peptide antibiotics: an unexpected link to a protein-protein interaction site in translocase MraY by Rodolis, Maria T, Mihalyi, Agnes, Ducho, Christian, Eitel, Kornelia, Gust, Bertolt, Goss, Rebecca J M, Bugg, Timothy D H

“…The pacidamycin and muraymycin uridyl peptide antibiotics show some structural resemblance to an Arg-Trp-x-x-Trp sequence motif for protein-protein interaction…”
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Biogenesis of the Unique 4′,5′-Dehydronucleoside of the Uridyl Peptide Antibiotic Pacidamycin by Ragab, Amany E, Grüschow, Sabine, Tromans, Daniel R, Goss, Rebecca J. M

“…The pacidamycins belong to a class of antimicrobial nucleoside antibiotics that act by inhibiting the clinically unexploited target translocase I, a key enzyme…”
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Zelkovamycins B–E, Cyclic Octapeptides Containing Rare Amino Acid Residues from an Endophytic Kitasatospora sp by Hao, Xiaomeng, Yu, Jiaqing, Wang, Yujia, Connolly, Jack A, Liu, Yufeng, Zhang, Yuqin, Yu, Liyan, Cen, Shan, Goss, Rebecca J. M, Gan, Maoluo

“…Four unusual cyclopeptides, zelkovamycins B–E (1–4), were isolated from an endophytic Kitasatospora sp. Zelkovamycin B was featured by an unprecedented…”
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The saponins: polar isoprenoids with important and diverse biological activities by Osbourn, Anne, Goss, Rebecca J M, Field, Robert A

“…Saponins are polar molecules that consist of a triterpene or steroid aglycone with one or more sugar chains. They are one of the most numerous and diverse…”
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Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo by Sharma, Sunil V., Tong, Xiaoxue, Pubill-Ulldemolins, Cristina, Cartmell, Christopher, Bogosyan, Emma J. A., Rackham, Emma J., Marelli, Enrico, Hamed, Refaat B., Goss, Rebecca J. M.

“…Marrying synthetic biology with synthetic chemistry provides a powerful approach toward natural product diversification, combining the best of both worlds:…”
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Heck Diversification of Indole‐Based Substrates under Aqueous Conditions: From Indoles to Unprotected Halo‐tryptophans and Halo‐tryptophans in Natural Product Derivatives by Pubill‐Ulldemolins, Cristina, Sharma, Sunil V., Cartmell, Christopher, Zhao, Jinlian, Cárdenas, Paco, Goss, Rebecca J. M.

“…The blending of synthetic chemistry with biosynthetic processes provides a powerful approach to synthesis. Biosynthetic halogenation and synthetic…”
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Isotopic Labeling Studies Reveal the Patulin Detoxification Pathway by the Biocontrol Yeast Rhodotorula kratochvilovae LS11 by Pinedo, Cristina, Wright, Sandra A. I, Collado, Isidro G, Goss, Rebecca J. M, Castoria, Raffaello, Hrelia, Patrizia, Maffei, Francesca, Durán-Patrón, Rosa

“…Patulin (1) is a mycotoxin contaminant in fruit and vegetable products worldwide. Biocontrol agents, such as the yeast Rhodotorula kratochvilovae strain LS11,…”
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A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A by Bailey, Christopher S, Zarins-Tutt, Joseph S, Agbo, Matthias, Gao, Hong, Diego-Taboada, Alberto, Gan, Maoluo, Hamed, Refaat B, Abraham, Emily R, Mackenzie, Grahame, Evans, P. Andrew, Goss, Rebecca J. M

“…The photoprotection and isolation of marinomycin A using sporopollenin exine capsules (SpECs) derived from the spores of the plant Lycopodium clavatum is…”
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GenoChemetic Strategy for Derivatization of the Violacein Natural Product Scaffold by Lai, Hung-En, Obled, Alan M. C, Chee, Soo Mei, Morgan, Rhodri M, Lynch, Rosemary, Sharma, Sunil V, Moore, Simon J, Polizzi, Karen M, Goss, Rebecca J. M, Freemont, Paul S

“…Natural products and their analogues are often challenging to synthesize due to their complex scaffolds and embedded functional groups. Solely relying on…”
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