Search Results - "Gosnell, Martin"

Autofluorescent imprint of chronic constriction nerve injury identified by deep learning by Gosnell, Martin E., Staikopoulos, Vasiliki, Anwer, Ayad G., Mahbub, Saabah B., Hutchinson, Mark R., Mustafa, Sanam, Goldys, Ewa M.

“…Our understanding of chronic pain and the underlying molecular mechanisms remains limited due to a lack of tools to identify the complex phenomena responsible…”
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Oxidative stress, mitochondrial perturbations and fetal programming of renal disease induced by maternal smoking by Stangenberg, Stefanie, Nguyen, Long T., Chen, Hui, Al-Odat, Ibrahim, Killingsworth, Murray C., Gosnell, Martin E., Anwer, Ayad G., Goldys, Ewa M., Pollock, Carol A., Saad, Sonia

“…An adverse in-utero environment is increasingly recognized to predispose to chronic disease in adulthood. Maternal smoking remains the most common modifiable…”
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Non-Invasive Monitoring of Functional State of Articular Cartilage Tissue with Label-Free Unsupervised Hyperspectral Imaging by Mahbub, Saabah B., Guller, Anna, Campbell, Jared M., Anwer, Ayad G., Gosnell, Martin E., Vesey, Graham, Goldys, Ewa M.

“…Damage and degradation of articular cartilage leads to severe pain and loss of mobility. The development of new therapies for cartilage regeneration for…”
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Functional hyperspectral imaging captures subtle details of cell metabolism in olfactory neurosphere cells, disease-specific models of neurodegenerative disorders by Gosnell, Martin E., Anwer, Ayad G., Cassano, Juan C., Sue, Carolyn M., Goldys, Ewa M.

“…Hyperspectral imaging uses spectral and spatial image information for target detection and classification. In this work hyperspectral autofluorescence imaging…”
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Statistically strong label-free quantitative identification of native fluorophores in a biological sample by Mahbub, Saabah B., Plöschner, Martin, Gosnell, Martin E., Anwer, Ayad G., Goldys, Ewa M.

“…Bioimaging using endogenous cell fluorescence, without any external biomarkers makes it possible to explore cells and tissues in their original native state,…”
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Utilising Hyperspectral Autofluorescence Imaging in the Objective Assessment of Disease State and Pain in Patients with Rheumatoid Arthritis by Lees, Florence, Mahbub, Saabah B., Gosnell, Martin E., Campbell, Jared M., Weedon, Helen, Habibalahi, Abbas, Goldys, Ewa M., Wechalekar, Mihir D., Hutchinson, Mark R., Crotti, Tania N.

“…Rheumatoid Arthritis (RA) is a chronic inflammatory disease resulting in joint swelling and pain. Treatment options can be reliant on disease activity scores…”
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Non-invasive assessment of exfoliated kidney cells extracted from urine using multispectral autofluorescence features by Mahbub, Saabah B., Nguyen, Long T., Habibalahi, Abbas, Campbell, Jared M., Anwer, Ayad G., Qadri, Uzair M., Gill, Anthony, Chou, Angela, Wong, Muh Geot, Gosnell, Martin E., Pollock, Carol A., Saad, Sonia, Goldys, Ewa M.

“…Optimally preserved urinary exfoliated renal proximal tubule cells were assessed by multispectral imaging of cell autofluorescence. We demonstrated different…”
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Quantitative non-invasive cell characterisation and discrimination based on multispectral autofluorescence features by Gosnell, Martin E., Anwer, Ayad G., Mahbub, Saabah B., Menon Perinchery, Sandeep, Inglis, David W., Adhikary, Partho P., Jazayeri, Jalal A., Cahill, Michael A., Saad, Sonia, Pollock, Carol A., Sutton-McDowall, Melanie L., Thompson, Jeremy G., Goldys, Ewa M.

“…Automated and unbiased methods of non-invasive cell monitoring able to deal with complex biological heterogeneity are fundamentally important for biology and…”
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Non-destructive, label free identification of cell cycle phase in cancer cells by multispectral microscopy of autofluorescence by Campbell, Jared M, Habibalahi, Abbas, Mahbub, Saabah, Gosnell, Martin, Anwer, Ayad G, Paton, Sharon, Gronthos, Stan, Goldys, Ewa

“…Cell cycle analysis is important for cancer research. However, available methodologies have drawbacks including limited categorisation and reliance on…”
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Computer-assisted cystoscopy diagnosis of bladder cancer by Gosnell, Martin E., Polikarpov, Dmitry M., Goldys, Ewa M., Zvyagin, Andrei V., Gillatt, David A.

“…One of the most reliable methods for diagnosing bladder cancer is cystoscopy. Depending on the findings, this may be followed by a referral to a more…”
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Non-invasive real-time imaging of reactive oxygen species (ROS) using auto-fluorescence multispectral imaging technique: A novel tool for redox biology by Habibalahi, Abbas, Moghari, Mahdieh Dashtbani, Campbell, Jared M., Anwer, Ayad G., Mahbub, Saabah B., Gosnell, Martin, Saad, Sonia, Pollock, Carol, Goldys, Ewa M.

“…Detecting reactive oxygen species (ROS) that play a critical role as redox modulators and signalling molecules in biological systems currently requires…”
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Fluorescence quenching of free and bound NADH in HeLa cells determined by hyperspectral imaging and unmixing of cell autofluorescence by Rehman, Aziz Ul, Anwer, Ayad G, Gosnell, Martin E, Mahbub, Saabah B, Liu, Guozhen, Goldys, Ewa M

“…Carbonyl cyanide-p-trifluoro methoxyphenylhydrazone (FCCP) is a well-known mitochondrial uncoupling agent. We examined FCCP-induced fluorescence quenching of…”
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L-Carnitine reverses maternal cigarette smoke exposure-induced renal oxidative stress and mitochondrial dysfunction in mouse offspring by Nguyen, Long T, Stangenberg, Stefanie, Chen, Hui, Al-Odat, Ibrahim, Chan, Yik L, Gosnell, Martin E, Anwer, Ayad G, Goldys, Ewa M, Pollock, Carol A, Saad, Sonia

“…Maternal smoking is associated with metabolic disorders, renal underdevelopment, and a predisposition to chronic kidney disease in offspring, yet the…”
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Publisher Correction: Non-invasive assessment of exfoliated kidney cells extracted from urine using multispectral autofluorescence features by Mahbub, Saabah B., Nguyen, Long T., Habibalahi, Abbas, Campbell, Jared M., Anwer, Ayad G., Qadri, Uzair M., Gill, Anthony, Chou, Angela, Wong, Muh Geot, Gosnell, Martin E., Pollock, Carol A., Saad, Sonia, Goldys, Ewa M.

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Visible 532 nm laser irradiation of human adipose tissue-derived stem cells: Effect on proliferation rates, mitochondria membrane potential and autofluorescence by Anwer, Ayad G., Gosnell, Martin E., Perinchery, Sandeep M., Inglis, David W., Goldys, Ewa M.

“…Background and Objective The photobiological effect of laser light on cells and tissues originates from light absorption by endogenous chromophores and hence…”
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PGRMC1 effects on metabolism, genomic mutation and CpG methylation imply crucial roles in animal biology and disease by Thejer, Bashar M, Adhikary, Partho P, Teakel, Sarah L, Fang, Johnny, Weston, Paul A, Gurusinghe, Saliya, Anwer, Ayad G, Gosnell, Martin, Jazayeri, Jalal A, Ludescher, Marina, Gray, Lesley-Ann, Pawlak, Michael, Wallace, Robyn H, Pant, Sameer D, Wong, Marie, Fischer, Tamas, New, Elizabeth J, Fehm, Tanja N, Neubauer, Hans, Goldys, Ewa M, Quinn, Jane C, Weston, Leslie A, Cahill, Michael A

“…Progesterone receptor membrane component 1 (PGRMC1) is often elevated in cancers, and exists in alternative states of phosphorylation. A motif centered on…”
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Label‐Free Assessment of Key Biological Autofluorophores: Material Characteristics and Opportunities for Clinical Applications by Campbell, Jared M., Gosnell, Martin, Agha, Adnan, Handley, Shannon, Knab, Aline, Anwer, Ayad G., Bhargava, Akanksha, Goldys, Ewa M.

“…Autofluorophores are endogenous fluorescent compounds that naturally occur in the intra and extracellular spaces of all tissues and organs. Most have vital…”
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Hyperspectral microscopy can detect metabolic heterogeneity within bovine post-compaction embryos incubated under two oxygen concentrations (7% versus 20%) by Sutton-McDowall, Melanie L., Gosnell, Martin, Anwer, Ayad G., White, Melissa, Purdey, Malcolm, Abell, Andrew D., Goldys, Ewa M., Thompson, Jeremy G.

“…Abstract STUDY QUESTION Can we separate embryos cultured under either 7% or 20% oxygen atmospheres by measuring their metabolic heterogeneity? SUMMARY ANSWER…”
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Scar tissue classification using nonlinear optical microscopy and discriminant analysis by Kelf, Timothy Andrew, Gosnell, Martin, Sandnes, Bjornar, Guller, Anna E., Shekhter, Anatoly B., Zvyagin, Andrei V.

“…This paper addresses the scar tissue maturation process that occurs stepwise, and calls for reliable classification. The structure of collagen imaged by…”
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Non-Invasive Detection and Monitoring of Biochemistry in Cells and Tissues by Decomposing Autofluorescence by Gosnell, Martin E., Anwer, Ayad G., Cassano, Juan C., Sue, Carolyn M., Mahbub, Saabah B., Pernichery, Sandeep Menon, Inglis, David W., Nadort, Annemarie, Adhikary, Partho P., Jazayeri, Jalal A., Cahill, Michael A., Saad, Sonia, Pollock, Carol, Sutton-McDowall, Melanie L., Thompson, Jeremy G., Goldys, Ewa M.

“…Hyperspectral imaging based on endogenous contrast provides a new non-invasive method to characterise cells and tissues. Cellular content and maps of native…”
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