Search Results - "Gorza Scopel, Kézia Katiani"
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Main B‐cell epitopes of PvAMA‐1 and PvMSP‐9 are targeted by naturally acquired antibodies and epitope‐specific memory cells in acute and convalescent phases of vivax malaria
Published in Parasite immunology (01-05-2020)“…Although antibodies are considered critical for malaria protection, little is known about the mechanisms/factors that maintain humoral immunity, especially…”
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Dynamics of IgM and IgG Antibody Response Profile against Linear B-Cell Epitopes from Exoerythrocytic (CelTOS and TRAP) and Erythrocytic (CyRPA) Phases of Plasmodium vivax : Follow-Up Study
Published in Antibodies (Basel) (15-08-2024)“…Malaria is a serious health problem worldwide affecting mainly children and socially vulnerable people. The biological particularities of , such as the ability…”
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Characterization of T and B cell epitopes in PvCyRPA by studying the naturally acquired immune response in Brazilian Amazon communities
Published in Scientific reports (09-11-2024)“…Plasmodium vivax , a challenging species to eliminate, causes millions of malaria cases globally annually. Developing an effective vaccine is crucial in the…”
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In Vitro and in Vivo Antimalarial Activity, Cytotoxicity and Phytochemical HRMS2 Profile of Plants from the Western Pará State, Brazilian Amazonia
Published in Chemistry & biodiversity (01-01-2024)“…Ethnopharmacology and botanical taxonomy are valid criteria used to selecting plants for antimalarial bioprospection purposes. Based on these two criteria,…”
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Apical membrane protein 1‐specific antibody profile and temporal changes in peripheral blood B‐cell populations in Plasmodium vivax malaria
Published in Parasite immunology (01-09-2019)“…Plasmodium falciparum‐specific antibodies tend to be short‐lived, but their cognate memory B cells (MBCs) circulate in the peripheral blood of exposed subjects…”
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Lung Damage Induced by Plasmodium berghei ANKA in Murine Model of Malarial Infection is Mitigated by Dietary Supplementation with DHA-Rich Omega‑3
Published in ACS infectious diseases (11-10-2024)“…Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe complications that can occur in infections caused by any Plasmodium species…”
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Polymorphism evidence in Plasmodium (Haemamoeba) lutzi Lucena, 1939 (Apicomplexa, Haemosporida) isolated from Brazilian wild birds
Published in Parasitology international (01-06-2019)“…Plasmodium parasites can infect great variety of bird species around the world inflicting the so called avian malaria, an illness that could be fatal in some…”
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In vitro and in silico assessment of new beta amino ketones with antiplasmodial activity
Published in Revista da Sociedade Brasileira de Medicina Tropical (01-01-2022)“…BACKGROUNDBased on the current need for new drugs against malaria, our study evaluated eight beta amino ketones in silico and in vitro for potential…”
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DHA-rich fish oil plays a protective role against experimental cerebral malaria by controlling inflammatory and mechanical events from infection
Published in The Journal of nutritional biochemistry (01-01-2024)“…Every year, thousands of children, particularly those under 5 years old, die because of cerebral malaria (CM). Following conventional treatment, approximately…”
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Naturally acquired antibodies to merozoite surface protein (MSP)-1(19) and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil
Published in Memórias do Instituto Oswaldo Cruz (01-12-2007)“…To infer recent patterns of malaria transmission, we measured naturally acquired IgG antibodies to the conserved 19-kDa C-terminal region of the merozoite…”
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What do we know about the role of regulatory B cells (Breg) during the course of infection of two major parasitic diseases, malaria and leishmaniasis?
Published in Pathogens and global health (03-04-2017)“…Parasitic diseases, such as malaria and leishmaniasis, are relevant public health problems worldwide. For both diseases, the alarming number of clinical cases…”
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New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo
Published in Bioorganic & medicinal chemistry letters (01-06-2015)“…[Display omitted] Malaria continues to be an important public health problem in the world. Nowadays, the widespread parasite resistance to many drugs used in…”
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In Vitro and in Vivo Antimalarial Activity, Cytotoxicity and Phytochemical HRMS 2 Profile of Plants from the Western Pará State, Brazilian Amazonia
Published in Chemistry & biodiversity (01-01-2024)“…Ethnopharmacology and botanical taxonomy are valid criteria used to selecting plants for antimalarial bioprospection purposes. Based on these two criteria,…”
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A simple quinoline salt derivative is active in vitro against Plasmodiumfalciparum asexual blood stages and inhibits the development of cerebral malaria in murine model
Published in Chemico-biological interactions (01-03-2022)“…Chloroquine (CQ) was the most effective and widely used drug for the prophylaxis and treatment of severe and non-severe malaria. Although its prophylactic use…”
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Avaliação in silico e in vivo do perfil de metabolismo e toxicidade hepática de alcaloides β-carbolínicos sintéticos com prévia atividade antimalárica
Published in H.U. revista (06-02-2024)“…Introdução: A malária continua sendo um grave problema de saúde pública mundial, dado os elevados índices anuais de morbimortalidade. O tratamento baseia-se no…”
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Novel organic salts based on quinoline derivatives: The in vitro activity trigger apoptosis inhibiting autophagy in Leishmania spp
Published in Chemico-biological interactions (25-09-2018)“…Leishmaniases are infectious diseases, caused by protozoa of the Leishmania genus. These drugs present high toxicity, long-term administration, many adverse…”
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Dynamics of IgM and IgG Antibody Response Profile against Linear B-Cell Epitopes from Exoerythrocytic Phases of Plasmodium vivax: Follow-Up Study
Published in Antibodies (Basel) (01-09-2024)“…Malaria is a serious health problem worldwide affecting mainly children and socially vulnerable people. The biological particularities of P. vivax , such as…”
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Polymorphism of the Fcgamma receptor IIA and malaria morbidity
Published in Journal of molecular and genetic medicine (28-07-2005)“…Fc receptors (FcRs) are expressed on the surface of all types of cells of the immune system. They bind the Fc portion of immunoglobulin (Ig), thereby bridging…”
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Polymorphism of the Fcγ receptor IIA and malaria morbidity
Published in Journal of molecular and genetic medicine (28-07-2005)“…Fc receptors (FcRs) are expressed on the surface of all types of cells of the immune system. They bind the Fc portion of immunoglobulin (Ig), thereby bridging…”
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