Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab

Progressive multifocal leukoencephalopathy (PML) is increasingly being reported in patients undergoing immunotherapy. We report a case of progressive multifocal leukoencephalopathy after treatment with nivolumab, a PD-1 blocker that is used to restore impaired T-cell responses in patients with cance...

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Bibliographic Details
Published in:	Emerging infectious diseases Vol. 24; no. 8; pp. 1594 - 1596
Main Authors:	Martinot, Martin, Ahle, Guido, Petrosyan, Inesa, Martinez, Camille, Gorun, Dragos M, Mohseni-Zadeh, Mahsa, Fafi-Kremer, Samira, Tebacher-Alt, Martine
Format:	Journal Article
Language:	English
Published:	United States U.S. National Center for Infectious Diseases 01-08-2018 Centers for Disease Control and Prevention
Subjects:	Aged Antineoplastic Agents, Immunological - administration & dosage Antineoplastic Agents, Immunological - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Care and treatment Female Health aspects Hodgkin Disease - diagnostic imaging Hodgkin Disease - drug therapy Hodgkin Disease - pathology Hodgkin Disease - virology Humans Hydrocortisone - therapeutic use immune checkpoint inhibitor Immunotherapy JC virus JC Virus - isolation & purification Leukoencephalopathy, Progressive Multifocal - diagnostic imaging Leukoencephalopathy, Progressive Multifocal - etiology Leukoencephalopathy, Progressive Multifocal - pathology Leukoencephalopathy, Progressive Multifocal - virology Lymphomas Magnetic Resonance Imaging Male meningtitis/encephalaitis Middle Aged Monoclonal antibodies nivolumab Nivolumab - administration & dosage Nivolumab - adverse effects Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - immunology Progressive multifocal leukoencephalopathy Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab Research Letter T cells Viremia - diagnostic imaging Viremia - etiology Viremia - pathology Viremia - virology viruses France immune checkpoint inhibitor viruses nivolumab HIV/AIDS and other retroviruses JC virus progressive multifocal leukoencephalopathy meningtitis/encephalitis
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Summary:	Progressive multifocal leukoencephalopathy (PML) is increasingly being reported in patients undergoing immunotherapy. We report a case of progressive multifocal leukoencephalopathy after treatment with nivolumab, a PD-1 blocker that is used to restore impaired T-cell responses in patients with cancer and infections. Data for 4 other cases were obtained from pharmacovigilance databases.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2408.180460