Search Results - "Gorter, J. A."

Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy by Aronica, E., Fluiter, K., Iyer, A., Zurolo, E., Vreijling, J., Van Vliet, E. A., Baayen, J. C., Gorter, J. A.

“…Increasing evidence supports the involvement of inflammatory and immune processes in temporal lobe epilepsy (TLE). MicroRNAs (miRNA) represent small regulatory…”
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Blood–brain barrier leakage may lead to progression of temporal lobe epilepsy by van Vliet, E. A., da Costa Araújo, S., Redeker, S., van Schaik, R., Aronica, E., Gorter, J. A.

“…Leakage of the blood–brain barrier (BBB) is associated with various neurological disorders, including temporal lobe epilepsy (TLE). However, it is not known…”
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Effects of rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo - in search of potential anti-epileptogenic strategies for temporal lobe epilepsy by Drion, C M, van Scheppingen, J, Arena, A, Geijtenbeek, K W, Kooijman, L, van Vliet, E A, Aronica, E, Gorter, J A

“…Previous studies in various rodent epilepsy models have suggested that mammalian target of rapamycin (mTOR) inhibition with rapamycin has anti-epileptogenic…”
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Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy by Korotkov, A., Mills, J. D., Gorter, J. A., van Vliet, E. A., Aronica, E.

“…Temporal lobe epilepsy (TLE) is a common chronic neurological disease in humans. A number of studies have demonstrated differential expression of miRNAs in the…”
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Role of blood–brain barrier in temporal lobe epilepsy and pharmacoresistance by van Vliet, E.A, Aronica, E, Gorter, J.A

“…Highlights • Blood–brain barrier changes in epileptogenic brain tissue. • Role of BBB in the development and progression of epilepsy. • Role of BBB in the…”
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The Roof is Leaking and a Storm is Raging: Repairing the Blood–Brain Barrier in the Fight Against Epilepsy by Gorter, J.A., Aronica, E., van Vliet, E.A.

“…A large body of evidence that has accumulated over the past decade strongly supports the role of both blood–brain barrier (BBB) dysfunction and perivascular…”
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CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies by Zurolo, E, Iyer, A.M, Spliet, W.G.M, Van Rijen, P.C, Troost, D, Gorter, J.A, Aronica, E

“…Abstract Recent data support the involvement of the endocannabinoid signaling in early brain development, as well as a key role of cannabinoid receptors (CBR)…”
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Longitudinal assessment of blood–brain barrier leakage during epileptogenesis in rats. A quantitative MRI study by van Vliet, E.A, Otte, W.M, Gorter, J.A, Dijkhuizen, R.M, Wadman, W.J

“…Abstract The blood–brain barrier (BBB) plays an important role in the homeostasis of the brain. BBB dysfunction has been implicated in the pathophysiology of…”
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Differential expression patterns of chloride transporters, Na+ -K+ -2Cl− -cotransporter and K+ -Cl− -cotransporter, in epilepsy-associated malformations of cortical development by Aronica, E, Boer, K, Redeker, S, Spliet, W.G.M, van Rijen, P.C, Troost, D, Gorter, J.A

“…Abstract Malformations of cortical development are recognized causes of chronic medically intractable epilepsy. An increasing number of observations suggests…”
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Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy by Holtman, L, van Vliet, E.A, van Schaik, R, Queiroz, C.M, Aronica, E, Gorter, J.A

“…Summary Inflammation is an important biological process that is activated after status epilepticus and could be implicated in the development of epilepsy. Here…”
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Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies by Iyer, A.M, Zurolo, E, Boer, K, Baayen, J.C, Giangaspero, F, Arcella, A, Di Gennaro, G.C, Esposito, V, Spliet, W.G.M, van Rijen, P.C, Troost, D, Gorter, J.A, Aronica, E

“…Abstract A growing body of evidence demonstrates the involvement of plasminogen activators (PAs) in a number of physiologic and pathologic events in the CNS…”
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Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats by van Vliet, E A, van Schaik, R, Edelbroek, P M, Voskuyl, R A, Redeker, S, Aronica, E, Wadman, W J, Gorter, J A

“…Recent studies have suggested that overexpression of the multidrug transporter P-glycoprotein (P-gp) in the hippocampal region leads to decreased levels of…”
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Gene expression profile analysis of epilepsy-associated gangliogliomas by Aronica, E, Boer, K, Becker, A, Redeker, S, Spliet, W.G.M, van Rijen, P.C, Wittink, F, Breit, T, Wadman, W.J, Lopes da Silva, F.H, Troost, D, Gorter, J.A

“…Abstract Gangliogliomas (GG) constitute the most frequent tumor entity in young patients undergoing surgery for intractable epilepsy. The histological…”
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Cellular localization of metabotropic glutamate receptors in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex by Boer, K, Troost, D, Timmermans, W, Gorter, J.A, Spliet, W.G.M, Nellist, M, Jansen, F, Aronica, E

“…Abstract Tuberous sclerosis complex (TSC) is an autosomal dominant disorder associated with cortical malformations (cortical tubers) and the development of…”
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Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: Focal cortical dysplasia and glioneuronal tumors by ARONICA, E, GORTER, J. A, JANSEN, G. H, VAN VEELEN, C. W. M, VAN RIJEN, P. C, LEENSTRA, S, RAMKEMA, M, SCHEFFER, G. L, SCHEPER, R. J, TROOST, D

“…The cell-specific distribution of multidrug resistance extrusion pumps was studied in developmental glioneuronal lesions, including focal cortical dysplasia…”
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Blood–brain barrier dysfunction, seizures and epilepsy by van Vliet, E.A., Aronica, E., Gorter, J.A.

“…The blood–brain barrier (BBB) is a dynamic and complex system which separates the brain from the blood. It helps to maintain the homeostasis of the brain,…”
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Complement protein 6 deficiency in PVG/c rats does not lead to neuroprotection against seizure induced cell death by Holtman, L, van Vliet, E.A, Baas, F, Aronica, E, Gorter, J.A

“…Abstract Since the membrane attack complex (MAC), an end product of the activated complement cascade, has been shown to play a role in neurodegeneration, we…”
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Distribution, characterization and clinical significance of microglia in glioneuronal tumours from patients with chronic intractable epilepsy by Aronica, E., Gorter, J. A., Redeker, S., Ramkema, M., Spliet, W. G. M., Van Rijen, P. C., Leenstra, S., Troost, D.

“…Cells of the microglia/macrophage lineage represent an important component of different brain tumours. However, there is little information about the…”
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Inhibitory networks in epilepsy-associated gangliogliomas and in the perilesional epileptic cortex by Aronica, E, Redeker, S, Boer, K, Spliet, W.G.M, van Rijen, P.C, Gorter, J.A, Troost, D

“…Summary Developmental glioneuronal lesions, such as gangliogliomas (GG) are increasingly recognized causes of chronic pharmaco-resistant epilepsy. It has been…”
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Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons by Gorter, J. A., Van Vliet, E. A., Aronica, E., Da Silva, F. H. Lopes

“…The development of spontaneous limbic seizures was investigated in a rat model in which electrical tetanic stimulation of the angular bundle was applied for up…”
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