Search Results - "Gorter, A."

MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response by Iyer, Anand, Zurolo, Emanuele, Prabowo, Avanita, Fluiter, Kees, Spliet, Wim G M, van Rijen, Peter C, Gorter, Jan A, Aronica, Eleonora

“…Increasing evidence supports the involvement of microRNAs (miRNA) in the regulation of inflammation in human neurological disorders. In the present study we…”
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Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury by van Vliet, Erwin A., Ndode-Ekane, Xavier Ekolle, Lehto, Lauri J., Gorter, Jan A., Andrade, Pedro, Aronica, Eleonora, Gröhn, Olli, Pitkänen, Asla

“…Traumatic brain injury (TBI) causes 10–20% of acquired epilepsy, which typically develops within 2 years post-injury with poorly understood mechanisms. We…”
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Status epilepticus, blood–brain barrier disruption, inflammation, and epileptogenesis by Gorter, Jan A, van Vliet, Erwin A, Aronica, Eleonora

“…Abstract Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature and inflammation as important players in epileptogenic…”
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Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target by Galanopoulou, Aristea S., Gorter, Jan A., Cepeda, Carlos

“…Summary The mammalian target of rapamycin (mTOR) signaling pathway regulates cell growth, differentiation, proliferation, and metabolism. Loss‐of‐function…”
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Advances in the development of biomarkers for epilepsy by Pitkänen, Asla, Prof, Löscher, Wolfgang, Prof, Vezzani, Annamaria, Prof, Becker, Albert J, Prof, Simonato, Michele, Prof, Lukasiuk, Katarzyna, Prof, Gröhn, Olli, Prof, Bankstahl, Jens P, PhD, Friedman, Alon, Prof, Aronica, Eleonora, Prof, Gorter, Jan A, Prof, Ravizza, Teresa, PhD, Sisodiya, Sanjay M, Prof, Kokaia, Merab, Prof, Beck, Heinz, Prof

“…Summary Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy remains unsatisfactorily controlled despite the availability of…”
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Neuroinflammatory targets and treatments for epilepsy validated in experimental models by Aronica, Eleonora, Bauer, Sebastian, Bozzi, Yuri, Caleo, Matteo, Dingledine, Raymond, Gorter, Jan A., Henshall, David C., Kaufer, Daniela, Koh, Sookyong, Löscher, Wolfgang, Louboutin, Jean‐Pierre, Mishto, Michele, Norwood, Braxton A., Palma, Eleonora, Poulter, Michael O., Terrone, Gaetano, Vezzani, Annamaria, Kaminski, Rafal M.

“…Summary A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy…”
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Cold and hunger induce diurnality in a nocturnal mammal by van der Vinne, Vincent, Riede, Sjaak J., Gorter, Jenke A., Eijer, Willem G., Sellix, Michael T., Menaker, Michael, Daan, Serge, Pilorz, Violetta, Hut, Roelof A.

“…Significance The circadian system drives daily rhythms in physiology and behavior. Mammals in nature can change their daily activity rhythms, but causes and…”
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Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy by Aronica, E., Fluiter, K., Iyer, A., Zurolo, E., Vreijling, J., Van Vliet, E. A., Baayen, J. C., Gorter, J. A.

“…Increasing evidence supports the involvement of inflammatory and immune processes in temporal lobe epilepsy (TLE). MicroRNAs (miRNA) represent small regulatory…”
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Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy by Gorter, Jan A, Iyer, Anand, White, Ian, Colzi, Anna, van Vliet, Erwin A, Sisodiya, Sanjay, Aronica, Eleonora

“…Abstract Since aberrant miRNA expression has been implicated in numerous brain diseases, we studied miRNA expression and miRNA regulation of important…”
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Effects of rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo - in search of potential anti-epileptogenic strategies for temporal lobe epilepsy by Drion, C M, van Scheppingen, J, Arena, A, Geijtenbeek, K W, Kooijman, L, van Vliet, E A, Aronica, E, Gorter, J A

“…Previous studies in various rodent epilepsy models have suggested that mammalian target of rapamycin (mTOR) inhibition with rapamycin has anti-epileptogenic…”
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Initial mutations direct alternative pathways of protein evolution by Salverda, Merijn L M, Dellus, Eynat, Gorter, Florien A, Debets, Alfons J M, van der Oost, John, Hoekstra, Rolf F, Tawfik, Dan S, de Visser, J Arjan G M

“…Whether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis…”
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Blood–brain barrier leakage may lead to progression of temporal lobe epilepsy by van Vliet, E. A., da Costa Araújo, S., Redeker, S., van Schaik, R., Aronica, E., Gorter, J. A.

“…Leakage of the blood–brain barrier (BBB) is associated with various neurological disorders, including temporal lobe epilepsy (TLE). However, it is not known…”
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The role of vitamin D in human fracture healing: a systematic review of the literature by Gorter, Erwin A, Hamdy, Neveen A.T, Appelman-Dijkstra, Natasha M, Schipper, Inger B

“…Abstract Introduction Vitamin D is essential for bone mineralization and for the subsequent maintenance of bone quality. Mineralization is part of hard callus…”
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Diurnality as an energy-saving strategy: energetic consequences of temporal niche switching in small mammals by van der Vinne, Vincent, Gorter, Jenke A, Riede, Sjaak J, Hut, Roelof A

“…Endogenous daily (circadian) rhythms allow organisms to anticipate daily changes in the environment. Most mammals are specialized to be active during the night…”
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The nutritional and hedonic value of food modulate sexual receptivity in Drosophila melanogaster females by Gorter, Jenke A., Jagadeesh, Samyukta, Gahr, Christoph, Boonekamp, Jelle J., Levine, Joel D., Billeter, Jean-Christophe

“…Food and sex often go hand in hand because of the nutritional cost of reproduction. For Drosophila melanogaster females, this relationship is especially…”
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Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs by Vliet, Erwin A., Puhakka, Noora, Mills, James D., Srivastava, Prashant K., Johnson, Michael R., Roncon, Paolo, Das Gupta, Shalini, Karttunen, Jenni, Simonato, Michele, Lukasiuk, Katarzyna, Gorter, Jan A., Aronica, Eleonora, Pitkänen, Asla

“…Summary The World Health Organization estimates that globally 2.4 million people are diagnosed with epilepsy each year. In nearly 30% of these cases, epilepsy…”
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Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy by Korotkov, A., Mills, J. D., Gorter, J. A., van Vliet, E. A., Aronica, E.

“…Temporal lobe epilepsy (TLE) is a common chronic neurological disease in humans. A number of studies have demonstrated differential expression of miRNAs in the…”
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Experimental Evolution of Interference Competition by Gorter, Florien A, Tabares-Mafla, Carolina, Kassen, Rees, Schoustra, Sijmen E

“…The importance of interference competition, where individuals compete through antagonistic traits such as the production of toxins, has long been recognized by…”
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Which insights have we gained from the kindling and post-status epilepticus models? by Gorter, Jan A., van Vliet, Erwin A., Lopes da Silva, Fernando H.

“…•Kindling is associated with mild neuropathological and molecular changes.•Spontaneous temporal lobe seizures occur only after overkindling.•The kindling model…”
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Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy by Aronica, Eleonora, Zurolo, Emanuele, Iyer, Anand, de Groot, Marjolein, Anink, Jasper, Carbonell, Caterina, van Vliet, Erwin A., Baayen, Johannes C., Boison, Detlev, Gorter, Jan A.

“…Summary Purpose:  Adenosine kinase (ADK) represents the key metabolic enzyme for the regulation of extracellular adenosine levels in the brain. In adult brain,…”
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