Search Results - "Gorski, Mathias"

Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals by Stanzick, Kira J., Li, Yong, Schlosser, Pascal, Gorski, Mathias, Wuttke, Matthias, Thomas, Laurent F., Rasheed, Humaira, Rowan, Bryce X., Graham, Sarah E., Vanderweff, Brett R., Patil, Snehal B., Robinson-Cohen, Cassiane, Gaziano, John M., O’Donnell, Christopher J., Willer, Cristen J., Hallan, Stein, Åsvold, Bjørn Olav, Gessner, Andre, Hung, Adriana M., Pattaro, Cristian, Köttgen, Anna, Stark, Klaus J., Heid, Iris M., Winkler, Thomas W.

“…Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing…”
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Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program by Hellwege, Jacklyn N., Velez Edwards, Digna R., Giri, Ayush, Qiu, Chengxiang, Park, Jihwan, Torstenson, Eric S., Keaton, Jacob M., Wilson, O. D., Robinson-Cohen, Cassianne, Chung, Cecilia P., Roumie, Christianne L., Klarin, Derek, Damrauer, Scott M., DuVall, Scott L., Siew, Edward, Akwo, Elvis A., Wuttke, Matthias, Gorski, Mathias, Li, Man, Li, Yong, Gaziano, J. Michael, Wilson, Peter W. F., Tsao, Philip S., O’Donnell, Christopher J., Kovesdy, Csaba P., Pattaro, Cristian, Köttgen, Anna, Susztak, Katalin, Edwards, Todd L., Hung, Adriana M.

“…Chronic kidney disease (CKD), defined by low estimated glomerular filtration rate (eGFR), contributes to global morbidity and mortality. Here we conduct a…”
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EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data by Winkler, Thomas W, Kutalik, Zoltan, Gorski, Mathias, Lottaz, Claudio, Kronenberg, Florian, Heid, Iris M

“…The R package EasyStrata facilitates the evaluation and visualization of stratified genome-wide association meta-analyses (GWAMAs) results. It provides (i)…”
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KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies by Stanzick, Kira J, Stark, Klaus J, Gorski, Mathias, Schödel, Johannes, Krüger, René, Kronenberg, Florian, Warth, Richard, Heid, Iris M, Winkler, Thomas W

“…Abstract Background Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with kidney function. By combining these…”
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Nuclear and mitochondrial genetic variants associated with mitochondrial DNA copy number by Koller, Adriana, Filosi, Michele, Weissensteiner, Hansi, Fazzini, Federica, Gorski, Mathias, Pattaro, Cristian, Schönherr, Sebastian, Forer, Lukas, Herold, Janina M., Stark, Klaus J., Döttelmayer, Patricia, Hicks, Andrew A., Pramstaller, Peter P., Würzner, Reinhard, Eckardt, Kai-Uwe, Heid, Iris M., Fuchsberger, Christian, Lamina, Claudia, Kronenberg, Florian

“…Mitochondrial DNA copy number (mtDNA-CN) is a biomarker for mitochondrial dysfunction associated with several diseases. Previous genome-wide association…”
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Investigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci by Winkler, Thomas W, Brandl, Caroline, Grassmann, Felix, Gorski, Mathias, Stark, Klaus, Loss, Julika, Weber, Bernhard H F, Heid, Iris M

“…Late-stage age-related macular degeneration (AMD) is the leading cause of visual impairment in the elderly with a complex etiology. The most important…”
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LMX1B is Essential for the Maintenance of Differentiated Podocytes in Adult Kidneys by BURGHARDT, Tillmann, KASTNER, Jürgen, DE VRIES, Uwe, SCHMIDT, Helga, HERTTING, Irmgard, KOPP, Jeffrey, RASCLE, Anne, MOSER, Markus, HEID, Iris M, WARTH, Richard, SPANG, Rainer, WEGENER, Joachim, SULEIMAN, Hani, MIERKE, Claudia T, ENGLERT, Christoph, WITZGALL, Ralph, RIVERA-MILLA, Eric, STEPANOVA, Natalya, LOTTAZ, Claudio, KUBITZA, Marion, BÖGER, Carsten A, SCHMIDT, Sarah, GORSKI, Mathias

“…Mutations of the LMX1B gene cause nail-patella syndrome, a rare autosomal-dominant disorder affecting the development of the limbs, eyes, brain, and kidneys…”
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Poor risk factor control in outpatients with diabetes mellitus type 2 in Germany: The DIAbetes COhoRtE (DIACORE) study by Rheinberger, Myriam, Jung, Bettina, Segiet, Thomas, Nusser, Johann, Kreisel, Günther, Andreae, Axel, Manz, Jochen, Haas, Gerhard, Banas, Bernhard, Stark, Klaus, Lammert, Alexander, Gorski, Mathias, Heid, Iris M, Krämer, Bernhard K, Böger, Carsten A

“…Patients with diabetes mellitus type 2 (DM2) are at high risk for micro- and macrovascular disease. Here, we explore the degree of traditional risk factor…”
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A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population by Voskarides, Konstantinos, Stefanou, Charalambos, Pieri, Myrtani, Demosthenous, Panayiota, Felekkis, Kyriakos, Arsali, Maria, Athanasiou, Yiannis, Xydakis, Dimitris, Stylianou, Kostas, Daphnis, Eugenios, Goulielmos, Giorgos, Loizou, Petros, Savige, Judith, Höhne, Martin, Völker, Linus A, Benzing, Thomas, Maxwell, Patrick H, Gale, Daniel P, Gorski, Mathias, Böger, Carsten, Kollerits, Barbara, Kronenberg, Florian, Paulweber, Bernhard, Zavros, Michalis, Pierides, Alkis, Deltas, Constantinos

“…Recent data emphasize that thin basement membrane nephropathy (TBMN) should not be viewed as a form of benign familial hematuria since chronic renal failure…”
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HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization by Fan, Qiao, Maranville, Joseph C, Fritsche, Lars, Sim, Xueling, Cheung, Chui Ming Gemmy, Chen, Li Jia, Gorski, Mathias, Yamashiro, Kenji, Ahn, Jeeyun, Laude, Augustinus, Dorajoo, Rajkumar, Lim, Tock Han, Teo, Yik-Ying, Blaustein, Robert O, Yoshimura, Nagahisa, Park, Kyu-Hyung, Pang, Chi Pui, Tai, E Shyong, Khor, Chiea Chuen, Wong, Tien Yin, Runz, Heiko, Cheng, Ching-Yu

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Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly - comparative results from the KORA and AugUR study by Herold, Janina M, Nano, Jana, Gorski, Mathias, Winkler, Thomas W, Stanzick, Kira J, Zimmermann, Martina E, Brandl, Caroline, Peters, Annette, Koenig, Wolfgang, Burkhardt, Ralph, Gessner, André, Heid, Iris M, Gieger, Christian, Stark, Klaus J

“…Polygenic scores (PGSs) combining genetic variants found to be associated with creatinine-based estimated glomerular filtration rate (eGFR ) have been applied…”
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Study design of DIACORE (DIAbetes COhoRtE) - a cohort study of patients with diabetes mellitus type 2 by Dörhöfer, Lena, Lammert, Alexander, Krane, Vera, Gorski, Mathias, Banas, Bernhard, Wanner, Christoph, Krämer, Bernhard K, Heid, Iris M, Böger, Carsten A

“…Diabetes mellitus type 2 (DM2) is highly associated with increased risk for chronic kidney disease (CKD), end stage renal disease (ESRD) and cardiovascular…”
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metaGWASmanager: a toolbox for an automated workflow from phenotypes to meta-analysis in GWAS consortia by Rodriguez-Hernandez, Zulema, Gorski, Mathias, Tellez-Plaza, Maria, Schlosser, Pascal, Wuttke, Matthias

“…Abstract Summary This article introduces the metaGWASmanager, which streamlines genome-wide association studies within large-scale meta-analysis consortia. It…”
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A catalog of genetic loci associated with kidney function from analyses of a million individuals by Wuttke, Matthias, Tin, Adrienne, Chai, Jin-Fang, Tayo, Bamidele O., Fuchsberger, Christian, Xu, Yizhe, Yu, Zhi, Akiyama, Masato, Ahluwalia, Tarunveer S., Amin, Najaf, Boissel, Mathilde, Boutin, Thibaud S., Brenner, Hermann, Campbell, Archie, Cusi, Daniele, Daw, E. Warwick, de Borst, Martin H., Delgado, Graciela, Dorajoo, Rajkumar, Elliott, Paul, Endlich, Karlhans, Franco, Oscar H., Franke, Andre, Freitag-Wolf, Sandra, Froguel, Philippe, Gaziano, J. Michael, Gieger, Christian, Gögele, Martin, Gudbjartsson, Daniel F., Gudnason, Vilmundur, Haller, Toomas, Hicks, Andrew A., Hofer, Edith, Ingelsson, Erik, Jaddoe, Vincent W. V., Jakobsdottir, Johanna, Jonas, Jost B., Joshi, Peter K., Jung, Bettina, Kerr, Shona M., Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Krajcoviechova, Alena, Krämer, Bernhard K., Kuokkanen, Mikko, Langefeld, Carl D., Lieb, Wolfgang, Lim, Su-Chi, Loos, Ruth J. F., Lucae, Susanne, Martins, Jade, Matsuda, Koichi, Milaneschi, Yuri, Miliku, Kozeta, Montgomery, Grant W., Nolte, Ilja M., Noordam, Raymond, Orho-Melander, Marju, Palsson, Runolfur, Perola, Markus, Pirastu, Mario, Podgornaia, Anna I., Ponte, Belen, Pramstaller, Peter P., Prins, Bram P., Raffield, Laura M., Ridker, Paul M., Roberts, David J., Rudan, Igor, Saba, Yasaman, Saum, Kai-Uwe, Schöttker, Ben, Smith, Albert V., Smith, Blair H., Taylor, Kent D., Thomsen, Hauke, Toniolo, Daniela, Tönjes, Anke, van Dam, Rob M., Verweij, Niek, Völker, Uwe, Wallentin, Lars, Waterworth, Dawn M., White, Harvey, Wild, Sarah H., Wilson, James F., Yerges-Armstrong, Laura M., Bochud, Murielle, Wilson, James G., Parsa, Afshin, Chasman, Daniel I., Pendergrass, Sarah A., Sim, Xueling, Böger, Carsten A., Okada, Yukinori, Hung, Adriana M., Scholz, Markus, Köttgen, Anna, Pattaro, Cristian

“…Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide…”
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Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels by Li, Yong, Wuttke, Matthias, Kirsten, Holger, Qiu, Chengxiang, Gorski, Mathias, Giri, Ayush, Li, Man, Noce, Damia, van der Most, Peter J., Horn, Katrin, Xu, Yizhe, Fuchsberger, Christian, Baptista, Daniela, Brumat, Marco, Campana, Eric, Campbell, Archie, Campbell, Harry, Carroll, Robert J., Catamo, Eulalia, Ciullo, Marina, Concas, Maria Pina, Coresh, Josef, De Grandi, Alessandro, Dittrich, Katalin, Eckardt, Kai-Uwe, Endlich, Karlhans, Evans, Michele K., Gieger, Christian, Gudbjartsson, Daniel F., Hicks, Andrew A., Hofer, Edith, Huang, Wei, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Ikram, M. Arfan, Jakobsdottir, Johanna, Jonsson, Helgi, Joshi, Peter K., Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Kamatani, Yoichiro, Kanai, Masahiro, Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Krämer, Bernhard K., Kronenberg, Florian, Kubo, Michiaki, Kühnel, Brigitte, Lange, Leslie A., Loeffler, Markus, Loos, Ruth J. F., Lyytikäinen, Leo-Pekka, Matsuda, Koichi, Meitinger, Thomas, Mishra, Pashupati P., Montgomery, Grant W., Müller-Nurasyid, Martina, Nadkarni, Girish N., Nolte, Ilja M., Noordam, Raymond, Perls, Thomas, Pirastu, Mario, Pistis, Giorgio, Ponte, Belen, Poulain, Tanja, Rabelink, Ton J., Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M., Rudan, Igor, Rueedi, Rico, Ryan, Kathleen A., Saba, Yasaman, Shaffer, Christian M., Smith, Albert V., Stumvoll, Michael, Thiery, Joachim, Thio, Chris H. L., Thorsteinsdottir, Unnur, Uitterlinden, André G., Völker, Uwe, Waldenberger, Melanie, Whitfield, John B., Wilson, James F., Zonderman, Alan B., Wilson, James G., Ho, Kevin, Parsa, Afshin, Psaty, Bruce M., Böger, Carsten A., Butterworth, Adam S., Stefansson, Kari, Heid, Iris M., Hung, Adriana M., Teumer, Alexander, Pattaro, Cristian, Woodward, Owen M., Vitart, Veronique

“…Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide…”
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Child maltreatment as a transdiagnostic risk factor for the externalizing dimension: a Mendelian randomization study by Konzok, Julian, Gorski, Mathias, Winkler, Thomas W, Baumeister, Sebastian E, Warrier, Varun, Leitzmann, Michael F, Baurecht, Hansjörg

“…Observational studies suggest that child maltreatment increases the risk of externalizing spectrum disorders such as attention deficit hyperactivity disorder…”
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T14. CHILD MALTREATMENT AS TRANSDIAGNOSTIC RISK FACTOR FOR THE EXTERNALIZING DIMENSION: A MENDELIAN RANDOMIZATION STUDY by Konzok, Julian, Baumeister, Sebastian E., Winkler, Thomas W., Gorski, Mathias, Warrier, Varun, Leitzmann, Michael F., Baurecht, Hansjörg

“…Observational studies indicate that child maltreatment raises the risk of externalizing spectrum disorders, such as attention deficit hyperactivity disorder…”
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HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization by Fan, Qiao, Maranville, Joseph C, Fritsche, Lars, Sim, Xueling, Cheung, Chui Ming Gemmy, Chen, Li Jia, Gorski, Mathias, Yamashiro, Kenji, Ahn, Jeeyun, Laude, Augustinus, Dorajoo, Rajkumar, Lim, Tock Han, Teo, Yik-Ying, Blaustein, Robert O, Yoshimura, Nagahisa, Park, Kyu-Hyung, Pang, Chi Pui, Tai, E Shyong, Khor, Chiea Chuen, Wong, Tien Yin, Runz, Heiko, Cheng, Ching-Yu

“…Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration…”
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Population-based reference values for kidney function and kidney function decline in 25- to 95-year-old Germans without and with diabetes by Herold, Janina M, Wiegrebe, Simon, Nano, Jana, Jung, Bettina, Gorski, Mathias, Thorand, Barbara, Koenig, Wolfgang, Zeller, Tanja, Zimmermann, Martina E, Burkhardt, Ralph, Banas, Bernhard, Küchenhoff, Helmut, Stark, Klaus J, Peters, Annette, Böger, Carsten A, Heid, Iris M

“…Understanding normal aging of kidney function is pivotal to help distinguish individuals at particular risk for chronic kidney disease. Glomerular filtration…”
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Genetic Risk Score Analysis Supports a Joint View of Two Classification Systems for Age-Related Macular Degeneration by Herold, Janina M., Zimmermann, Martina E., Gorski, Mathias, Günther, Felix, Weber, Bernhard H. F., Helbig, Horst, Stark, Klaus J., Heid, Iris M., Brandl, Caroline

“…PurposeThe purpose of this study was to evaluate the utility of combining the Clinical Classification (CC) and the Three Continent age-related macular…”
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