Search Results - "Gorshkova, Irina A."

Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells by Pendyala, Srikanth, Gorshkova, Irina A, Usatyuk, Peter V, He, Donghong, Pennathur, Arjun, Lambeth, J David, Thannickal, Victor J, Natarajan, Viswanathan

“…In vascular endothelium, the major research focus has been on reactive oxygen species (ROS) derived from Nox2. The role of Nox4 in endothelial signal…”
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Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression by Zhao, Yutong, Gorshkova, Irina A, Berdyshev, Evgeny, He, Donghong, Fu, Panfeng, Ma, Wenli, Su, Yanlin, Usatyuk, Peter V, Pendyala, Srikanth, Oskouian, Babak, Saba, Julie D, Garcia, Joe G N, Natarajan, Viswanathan

“…A defining feature of acute lung injury (ALI) is the increased lung vascular permeability and alveolar flooding, which leads to associated morbidity and…”
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Regulation of NADPH oxidase in vascular endothelium: the role of phospholipases, protein kinases, and cytoskeletal proteins by Pendyala, Srikanth, Usatyuk, Peter V, Gorshkova, Irina A, Garcia, Joe G N, Natarajan, Viswanathan

“…The generation of reactive oxygen species (ROS) in the vasculature plays a major role in the genesis of endothelial cell (EC) activation and barrier function…”
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Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis by Montesi, Sydney B, Mathai, Susan K, Brenner, Laura N, Gorshkova, Irina A, Berdyshev, Evgeny V, Tager, Andrew M, Shea, Barry S

“…Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no effective medical therapies. Recent research has focused on identifying the…”
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Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest by Gorshkova, Irina A., Wang, Huashan, Orbelyan, Gerasim A., Goya, Jonathan, Natarajan, Viswanathan, Beiser, David G., Vanden Hoek, Terry L., Berdyshev, Evgeny V.

“…To test the role of sphingosine-1-phosphate (S1P) signaling system in the in vivo setting of resuscitation and survival after cardiac arrest. A mouse model of…”
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De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells by Berdyshev, Evgeny V., Gorshkova, Irina A., Usatyuk, Peter, Zhao, Yutong, Saatian, Bahman, Hubbard, Walter, Natarajan, Viswanathan

“…Sphingosine kinase 1 (SK1) is one of the two known kinases, which generates sphingosine-1-phosphate (S1P), a potent endogenous lipid mediator involved in cell…”
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Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways by Usatyuk, Peter V, He, Donghong, Bindokas, Vytas, Gorshkova, Irina A, Berdyshev, Evgeny V, Garcia, Joe G N, Natarajan, Viswanathan

“…Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that mediates cellular functions by ligation via G protein-coupled S1P receptors. In addition to its…”
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Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography–tandem mass spectrometry by Berdyshev, Evgeny V., Gorshkova, Irina A., N. Garcia, Joe G., Natarajan, Viswanathan, Hubbard, Walter C.

“…Sphingosine-1-phosphate (S1P) and dihydrosphingosine-1-phosphate (DHS1P) are important signaling sphingolipids. The presence of nanomolar levels of S1P and…”
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Dynamin 2 and c-Abl Are Novel Regulators of Hyperoxia-mediated NADPH Oxidase Activation and Reactive Oxygen Species Production in Caveolin-enriched Microdomains of the Endothelium by Singleton, Patrick A., Pendyala, Srikanth, Gorshkova, Irina A., Mambetsariev, Nurbek, Moitra, Jaideep, Garcia, Joe G.N., Natarajan, Viswanathan

“…Reactive oxygen species (ROS) generation, particularly by the endothelial NADPH oxidase family of proteins, plays a major role in the pathophysiology…”
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Targeting sphingosine kinase 1 attenuates bleomycin‐induced pulmonary fibrosis by Huang, Long Shuang, Berdyshev, Evgeny, Mathew, Biji, Fu, Panfeng, Gorshkova, Irina A., He, Donghong, Ma, Wenli, Noth, Imre, Ma, Shwu‐Fan, Pendyala, Srikanth, Reddy, Sekhar P., Zhou, Tong, Zhang, Wei, Garzon, Steven A., Garcia, Joe G. N., Natarajan, Viswanathan

“…Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease, wherein transforming growth factor β (TGF‐β) and…”
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Phospholipase D-mediated Activation of IQGAP1 through Rac1 Regulates Hyperoxia-induced p47phox Translocation and Reactive Oxygen Species Generation in Lung Endothelial Cells by Usatyuk, Peter V., Gorshkova, Irina A., He, Donghong, Zhao, Yutong, Kalari, Satish K., Garcia, Joe G.N., Natarajan, Viswanathan

“…Phosphatidic acid generated by the activation of phospholipase D (PLD) functions as a second messenger and plays a vital role in cell signaling. Here we…”
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Autotaxin Production of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation by GYE YOUNG PARK, YONG GYU LEE, JING DENG, RANJAN, Ravi, LEI XIAO, ARI JAFFE, H, CORBRIDGE, Susan J, KELLY, Elizabeth A. B, JARJOUR, Nizar N, CHUN, Jerold, PRESTWICH, Glenn D, KAFFE, Eleanna, BERDYSHEV, Evgeny, NINOU, Ioanna, AIDINIS, Vassilis, MORRIS, Andrew J, SMYTH, Susan S, ACKERMAN, Steven J, NATARAJAN, Viswanathan, CHRISTMAN, John W, SHARMILEE NYENHUIS, JIAN DU, PANFENG FU, GORSHKOVA, Irina A, YONGCHAO LI, SANGWOON CHUNG, KARPURAPU, Manjula

“…Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors…”
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Marine alkaloid polycarpine and its synthetic derivative dimethylpolycarpine induce apoptosis in JB6 cells through p53- and caspase 3-dependent pathways by Fedorov, Sergey N, Bode, Ann M, Stonik, Valentin A, Gorshkova, Irina A, Schmid, Patricia C, Radchenko, Oleg S, Berdyshev, Evgueni V, Dong, Zigang

“…Polycarpine from ascidian Polycarpa aurata was previously found to be active against different human tumor cells. In this study, we investigated the antitumor…”
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Molecular characteristics of Mycobacterium tuberculosis drug-resistant isolates from HIV- and HIV+ tuberculosis patients in Russia by Panova, Anna E, Vinokurov, Anatoliy S, Shemetova, Anastasiya A, Burmistrova, Irina A, Shulgina, Marina V, Samoilova, Anastasiya G, Vasilyeva, Irina A, Vakhrusheva, Diana V, Umpeleva, Tatiana V, Eremeeva, Nataliya I, Lavrenchuk, Leonid S, Golubeva, Lyudmila A, Danilova, Tatiana I, Vasilyeva, Tatiana B, Ugol'kova, Vera A, Sosova, Nataliya V, Lekhlyaider, Marina V, Gorshkova, Irina A, Romanova, Tatiana A

“…High burden of drug-resistant (DR) tuberculosis (TB) is a significant threat to national TB control programs all over the world and in the Russian Federation…”
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Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival by Véret, Julien, Coant, Nicolas, Gorshkova, Irina A., Giussani, Paola, Fradet, Magali, Riccitelli, Elena, Skobeleva, Anastasia, Goya, Jonathan, Kassis, Nadim, Natarajan, Viswanathan, Portha, Bernard, Berdyshev, Evgeny V., Le Stunff, Hervé

“…Sphingoid base-1-phosphates represent a very low portion of the sphingolipid pool but are potent bioactive lipids in mammals. This study was undertaken to…”
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Phospholipase D-mediated Activation of IQGAP1 through Rac1 Regulates Hyperoxia-induced p47 Translocation and Reactive Oxygen Species Generation in Lung Endothelial Cells by Usatyuk, Peter V., Gorshkova, Irina A., He, Donghong, Zhao, Yutong, Kalari, Satish K., Garcia, Joe G.N., Natarajan, Viswanathan

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Novel Role for Non-muscle Myosin Light Chain Kinase (MLCK) in Hyperoxia-induced Recruitment of Cytoskeletal Proteins, NADPH Oxidase Activation, and Reactive Oxygen Species Generation in Lung Endothelium by Usatyuk, Peter V., Singleton, Patrick A., Pendyala, Srikanth, Kalari, Satish K., He, Donghong, Gorshkova, Irina A., Camp, Sara M., Moitra, Jaideep, Dudek, Steven M., Garcia, Joe G.N., Natarajan, Viswanathan

“…We recently demonstrated that hyperoxia (HO) activates lung endothelial cell NADPH oxidase and generates reactive oxygen species (ROS)/superoxide via…”
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Regulation of COX-2 Expression and IL-6 Release by Particulate Matter in Airway Epithelial Cells by Zhao, Yutong, Usatyuk, Peter V, Gorshkova, Irina A, He, Donghong, Wang, Ting, Moreno-Vinasco, Liliana, Geyh, Alison S, Breysse, Patrick N, Samet, Jonathan M, Spannhake, Ernst Wm, Garcia, Joe G. N, Natarajan, Viswanathan

“…Particulate matter (PM) in ambient air is a risk factor for human respiratory and cardiovascular diseases. The delivery of PM to airway epithelial cells has…”
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A new cytotoxic fatty acid (5Z,9Z)‐22‐methyl‐5,9‐tetracosadienoic acid and the sterols from the far Eastern sponge Geodinella robusta by Makarieva, Tatyana N., Santalova, Elena A., Gorshkova, Irina A., Dmitrenok, Andrei S., Guzii, Alla G., Gorbach, Vladimir I., Svetashev, Vassilii I., Stonik, Valentin A.

“…A new fatty acid, (5Z,9Z)‐22‐methyl‐5,9‐tetracosadienoic acid (1a), and a rare fatty acid, (5Z,9Z)‐23‐methyl‐5,9‐tetracosadienoic acid (2a), the predominant…”
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Do boundaries of soil animal and plant communities coincide? A case study of a Mediterranean forest in Russia by Gongalsky, Konstantin B., Gorshkova, Irina A., Karpov, Alexei I., Pokarzhevskii, Andrei D.

“…We studied the relationship between plant and soil animal communities by geostatistical analysis in a piedmont forest close to Novorossiysk (Southern Russia)…”
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