Taxonomic dysbiosis of gut microbiota and serum biomarkers reflect severity of central nervous system injury
The term “chronic critical illness” (CCI) refers to patients with prolonged dependence on intensive care. In most patients, CCI is triggered by severe brain injury. Ever more studies researching the microbiota in pathologic conditions are published every year, but a lot is yet to be elucidated about...
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| Published in: | Bulletin of RSMU no. 2020(5) |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-09-2020
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| Online Access: | Get full text |
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| Summary: | The term “chronic critical illness” (CCI) refers to patients with
prolonged dependence on intensive care. In most patients, CCI is triggered
by severe brain injury. Ever more studies researching the microbiota in
pathologic conditions are published every year, but a lot is yet to be
elucidated about the composition of the gut microbiota in CCI. The aim of
this study was to investigate possible correlations between changes in the
taxonomic abundance of the gut microbiota, levels of proinflammatory and
neurological serum biomarkers and the severity of central nervous system
injury in patients with CCI. Our prospective observational pilot study
included 29 patients with CCI. Using real-time PCR allowed us to detected
changes in the taxonomic abundance of the gut microbiota. The correlation
analysis of serum biomarkers and the taxonomic composition of the gut
microbiota revealed statistically significant correlations between cortisol
levels and the abundance of F. prausnitzii (r = ‒0.62; p < 0.05) and B.
thetaiotaomicron (r = ‒0.57; p < 0.05) in vegetative state patients;
between the CRP/albumin ratio and the abundance of S. aureus (r = 0.72; p
< 0.05); between the abundance of B. fragilis group/F. prausnitzii and
S100 levels (r = 0.45; p <0.05) in conscious patients; between Glasgow
coma scale scores and the abundance of Enterococcus spp. (r = ‒0.77; p
<0.05) in both groups. Thus, the association between the changes in the
taxonomic composition of the gut microbiota and the severity of neurologic
deficit can be evaluated using PCR-based diagnostic techniques and blood
serum biomarkers. This approach will help to optimize antibacterial
treatment regimens and/or develop alternative strategies to minimize the
aggressive effect of antibiotics on the gut microbiota. |
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| ISSN: | 2500-1094 2542-1204 |
| DOI: | 10.24075/brsmu.2020.053 |