Search Results - "Goronzy, Jörg J"

The immunology of rheumatoid arthritis by Weyand, Cornelia M., Goronzy, Jörg J.

“…The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the production of autoantibodies against post-translationally modified…”
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Mechanisms underlying T cell ageing by Goronzy, Jörg J., Weyand, Cornelia M.

“…T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and cancer and in impairing the response to vaccination. Easy…”
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Successful and Maladaptive T Cell Aging by Goronzy, Jörg J., Weyand, Cornelia M.

“…Throughout life, the T cell system adapts to shifting resources and demands, resulting in a fundamentally restructured immune system in older individuals. Here…”
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Immunometabolism in the development of rheumatoid arthritis by Weyand, Cornelia M., Goronzy, Jörg J.

“…In rheumatoid arthritis (RA), breakdown of self‐tolerance and onset of clinical disease are separated in time and space, supporting a multi‐hit model in which…”
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Immunometabolism in early and late stages of rheumatoid arthritis by Weyand, Cornelia M., Goronzy, Jörg J.

“…Key Points A fundamental abnormality in rheumatoid arthritis (RA) is the inappropriate growth of immune cells and stromal cells, imposing high metabolic…”
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Influence of immune aging on vaccine responses by Gustafson, Claire E., Kim, Chulwoo, Weyand, Cornelia M., Goronzy, Jörg J.

“…Impaired vaccine responses in older individuals are associated with alterations in both the quantity and quality of the T-cell compartment with age. As…”
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Understanding immunosenescence to improve responses to vaccines by Goronzy, Jörg J, Weyand, Cornelia M

“…In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly because of the adaptive immune system's inability to generate…”
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Hallmarks of the aging T‐cell system by Zhang, Huimin, Weyand, Cornelia M., Goronzy, Jörg J.

“…The adaptive immune system has the enormous challenge to protect the host through the generation and differentiation of pathogen‐specific short‐lived effector…”
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Inhibition of JAK-STAT Signaling Suppresses Pathogenic Immune Responses in Medium and Large Vessel Vasculitis by Zhang, Hui, Watanabe, Ryu, Berry, Gerald J, Tian, Lu, Goronzy, Jörg J, Weyand, Cornelia M

“…BACKGROUND:Giant cell arteritis, a chronic autoimmune disease of the aorta and its large branches, is complicated by aneurysm formation, dissection, and…”
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Metabolic signatures of T-cells and macrophages in rheumatoid arthritis by Weyand, Cornelia M, Zeisbrich, Markus, Goronzy, Jörg J

“…Highlights • In the autoimmune disease, rheumatoid arthritis (RA), abnormal metabolic programs have been identified in arthritogenic T-cells and in…”
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Naive T cell maintenance and function in human aging by Goronzy, Jörg J, Fang, Fengqin, Cavanagh, Mary M, Qi, Qian, Weyand, Cornelia M

“…In studies of immune aging, naive T cells frequently take center stage. Describing the complexity of the human naive T cell repertoire remains a daunting task;…”
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Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis by Zhang, Hui, Watanabe, Ryu, Berry, Gerald J., Vaglio, Augusto, Liao, Yaping Joyce, Warrington, Kenneth J., Goronzy, Jörg J., Weyand, Cornelia M.

“…Giant cell arteritis (GCA) causes autoimmune inflammation of the aorta and its large branches, resulting in aortic arch syndrome, blindness, and stroke. CD4⁺ T…”
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Diversity and clonal selection in the human T-cell repertoire by Qi, Qian, Liu, Yi, Cheng, Yong, Glanville, Jacob, Zhang, David, Lee, Ji-Yeun, Olshen, Richard A., Weyand, Cornelia M., Boyd, Scott D., Goronzy, Jörg J.

“…T-cell receptor (TCR) diversity, a prerequisite for immune system recognition of the universe of foreign antigens, is generated in the first two decades of…”
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Immune mechanisms in medium and large-vessel vasculitis by Weyand, Cornelia M., Goronzy, Jörg J.

“…Key Points Giant cell arteritis (GCA), the most frequent form of large-vessel vasculitis, occurs in a strictly defined tissue context and requires corruption…”
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Immune checkpoint dysfunction in large and medium vessel vasculitis by Watanabe, Ryu, Zhang, Hui, Berry, Gerald, Goronzy, Jörg J, Weyand, Cornelia M

“…Giant cell arteritis (GCA) is a granulomatous vasculitis of the aorta and its medium-sized branch vessels. CD4 T cells, macrophages, and dendritic cells (DCs)…”
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T cell fate decisions during memory cell generation with aging by Sturmlechner, Ines, Jain, Abhinav, Mu, Yunmei, Weyand, Cornelia M., Goronzy, Jörg J.

“…The defense against infectious diseases, either through natural immunity or after vaccinations, relies on the generation and maintenance of protective T cell…”
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The Transcription Factor TCF1 in T Cell Differentiation and Aging by Kim, Chulwoo, Jin, Jun, Weyand, Cornelia M, Goronzy, Jörg J

“…The transcription factor T cell factor 1 (TCF1), a pioneer transcription factor as well as a downstream effector of WNT/β-catenin signaling, is indispensable…”
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Immune aging and autoimmunity by Goronzy, Jörg J., Weyand, Cornelia M.

“…Age is an important risk for autoimmunity, and many autoimmune diseases preferentially occur in the second half of adulthood when immune competence has…”
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MMP (Matrix Metalloprotease)-9–Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis by Watanabe, Ryu, Maeda, Toshihisa, Zhang, Hui, Berry, Gerald J, Zeisbrich, Markus, Brockett, Robert, Greenstein, Andrew E, Tian, Lu, Goronzy, Jörg J, Weyand, Cornelia M

“…RATIONALE:Giant cell arteritis (GCA)—a primary vasculitis of medium and large arteries—is associated with vessel wall damage, elastic membrane fragmentation,…”
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Autophagy in autoimmune disease by Yang, Zhen, Goronzy, Jörg J., Weyand, Cornelia M.

“…Autophagy is a protective and life-sustaining process in which cytoplasmic components are packaged into double-membrane vesicles and targeted to lysosomes for…”
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