Search Results - "Gorombei, Petra"

The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1 by Narayanan, Ashwin, Gagliardi, Filippo, Gallotti, Alberto L., Mazzoleni, Stefania, Cominelli, Manuela, Fagnocchi, Luca, Pala, Mauro, Piras, Ignazio S., Zordan, Paola, Moretta, Nicole, Tratta, Elisa, Brugnara, Gianluca, Altabella, Luisa, Bozzuto, Giuseppina, Gorombei, Petra, Molinari, Agnese, Padua, Rose-Ann, Bulfone, Alessandro, Politi, Letterio S., Falini, Andrea, Castellano, Antonella, Mortini, Pietro, Zippo, Alessio, Poliani, Pietro L., Galli, Rossella

“…Achaete-scute homolog 1 gene (ASCL1) is a gene classifier for the proneural (PN) transcriptional subgroup of glioblastoma (GBM) that has a relevant role in the…”
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BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome by Gorombei, Petra, Guidez, Fabien, Ganesan, Saravanan, Chiquet, Mathieu, Pellagatti, Andrea, Goursaud, Laure, Tekin, Nilgun, Beurlet, Stephanie, Patel, Satyananda, Guerenne, Laura, Le Pogam, Carole, Setterblad, Niclas, de la Grange, Pierre, LeBoeuf, Christophe, Janin, Anne, Noguera, Maria-Elena, Sarda-Mantel, Laure, Merlet, Pascale, Boultwood, Jacqueline, Konopleva, Marina, Andreeff, Michael, West, Robert, Pla, Marika, Adès, Lionel, Fenaux, Pierre, Krief, Patricia, Chomienne, Christine, Omidvar, Nader, Padua, Rose Ann

“…During transformation, myelodysplastic syndromes (MDS) are characterized by reducing apoptosis of bone marrow (BM) precursors. Mouse models of high risk…”
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GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways by Guerenne, Laura, Beurlet, Stéphanie, Said, Mohamed, Gorombei, Petra, Le Pogam, Carole, Guidez, Fabien, de la Grange, Pierre, Omidvar, Nader, Vanneaux, Valérie, Mills, Ken, Mufti, Ghulam J, Sarda-Mantel, Laure, Noguera, Maria Elena, Pla, Marika, Fenaux, Pierre, Padua, Rose Ann, Chomienne, Christine, Krief, Patricia

“…In spite of the recent discovery of genetic mutations in most myelodysplasic (MDS) patients, the pathophysiology of these disorders still remains poorly…”
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BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells by Beurlet, Stephanie, Omidvar, Nader, Gorombei, Petra, Krief, Patricia, Le Pogam, Carole, Setterblad, Niclas, de la Grange, Pierre, Leboeuf, Christophe, Janin, Anne, Noguera, Maria-Elena, Hervatin, Florence, Sarda-Mantel, Laure, Konopleva, Marina, Andreeff, Michael, Tu, Andrea W., Fan, Alice C., Felsher, Dean W., Whetton, Anthony, Pla, Marika, West, Robert, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann

“…Myelodysplastic syndrome (MDS) transforms into an acute myelogenous leukemia (AML) with associated increased bone marrow (BM) blast infiltration. Using a…”
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pVAX14 DNA, a Non-Specific DNA Vaccine, Improves Survival In An Acute Promyelocytic Leukemia (APL) Mouse Model Treated With All-Trans Retinoic Acid (ATRA) and Arsenic Trioxide (ATO) and Targets Leukemia Initiating Cells (LICs) by Patel, Satyananda, Guerenne, Laura, Le Pogam, Carole, Gorombei, Petra, Krief, Patricia, Schlageter, Marie-Helene, West, Robert, Mathews, Vikram, Pla, Marika, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann

“…The combination of ATRA and ATO is very effective in treating APL, both in mouse models (Lallemand JEM 1999) and in patients (Lo Coco NEJM 2013). Having…”
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pVAX14 DNA, An Immunoadjuvant, Extends Life-Span As Add-On Treatment To Azacitidine (AZA) In A Mouse Model Of High Risk Myelodysplastic Syndrome (HR-MDS) by Petra, Gorombei, Carole, Le Pogam, Krief, Patricia, Patel, Satyananda, Laura, Guerenne, Robert, West, Marika, Pla, Pierre, Fenaux, Christine, Chomienne, Padua, Rose Ann

“…We have established animal models of MDS and acute myelogenous leukemia (AML) using NRASD12 and overexpression of BCL-2 (Omidvar Cancer Res 2007). These models…”
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Efficacy of ABT-737, a BCL-2 Inhibitor, in an NRAS/BCL2 Mouse Model of High Risk Myelodysplasia (HR-MDS) By Targeting Pathways Identified By Gene Expression Profiling by Padua, Rose Ann, Gorombei, Petra, Beurlet, Stéphanie, Omidvar, Nader, Patel, Satyananda, Guerenne, Laura, Le Pogam, Carole, Setterblad, Niclas, de la Grange, Pierre, Guidez, Fabien, Le Boeuf, Christophe, Janin, Anne, Noguera, Maria-Elena, Sarda-Mantel, Laure, Merlet, Pascal, West, Robert, Pla, Marika, Fenaux, Pierre, Krief, Patricia, Chomienne, Christine

“…Background: MDS lack therapeutic approaches in many instances and very few animal models of MDS available for preclinical testing of new drugs have been…”
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DNA-mediated adjuvant immunotherapy extends survival in two different mouse models of myeloid malignancies by Le Pogam, Carole, Patel, Satyananda, Gorombei, Petra, Guerenne, Laura, Krief, Patricia, Omidvar, Nader, Tekin, Nilgun, Bernasconi, Elena, Sicre, Flore, Schlageter, Marie-Helene, Chopin, Martine, Noguera, Maria-Elena, West, Robert, Abu, Ansu, Mathews, Vikram, Pla, Marika, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann

“…We have previously shown that a specific promyelocytic leukemia-retinoic acid receptor alpha (PML-RARA) DNA vaccine combined with all-trans retinoic acid…”
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BCL-2 Inhibition with ABT-737 Prolongs Survival in an NRAS/BCL2-Mediated MOUSE MODEL of Myelodyspastic Syndrome (MDS) Progressing to ACUTE Myelogenous Leukemia (AML) by Targeting Leukemia Initiating CELLS by Gorombei, Petra, Stephanie, Beurlet, Omidvar, Nader, Patricia, Krief, Carole, Le Pogam, de la Grange, Pierre, Christophe, Leboeuf, Janin, Anne, Maria-Elena, Noguera, Konopleva, Marina, Andreeff, Michael, Marika, Pla, Robert, West, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann

“…Abstract 678 BCL-2 activation plays a role in the progression of MDS to AML and BCL 2 inhibition may represent a therapeutic target in such patients. Using our…”
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