Search Results - "Gorniak, Joselina G."

Inhibition of HSV-1 protease by benzoxazinones by Jarvest, Richard L., Parratt, Martin J., Debouck, Christine M., Gorniak, Joselina G., John Jennings, L., Serafinowska, Halina T., Strickler, James E.

“…Benzoxazinones have been discovered which are mechanism based inhibitors of HSV-1 protease with micromolar IC 50 values. Formation of a monoadduct consistent…”
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Novel, selective mechanism-based inhibitors of the herpes proteases by Pinto, Ivan L., West, Andrew, Debouck, Christine M., DiLella, Anthony G., Gorniak, Joselina G., O'Donnell, Kevin C., O'Shannessy, Daniel J., Patel, Arunbai, Jarvest, Richard L.

“…A novel class of inhibitor of the herpes proteases acting upon the catalytic apparatus by forming covalent complexes are described. Two new families of…”
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Potent selective thienoxazinone inhibitors of herpes proteases by Jarvest, Richard L., Connor, Susan C., Gorniak, Joselina G., Jennings, L.John, Serafinowska, Halina T., West, Andrew

“…Thieno[3,2-d]oxazinones are potent, selective, mechanism-based inhibitors of the herpes proteases with good aqueous stability. Specificity between the HSV and…”
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Human Immunodeficiency Virus Protease Expressed in Escherichia coli Exhibits Autoprocessing and Specific Maturation of the Gag Precursor by Debouck, Christine, Gorniak, Joselina G., Strickler, James E., Meek, Thomas D., Metcalf, Brian W., Rosenberg, Martin

“…The mature gag and pol proteins of human immunodeficiency virus (HIV) and all retroviruses derive from large gag and gag-pol polyprotein precursors by…”
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Human Immunodeficiency Virus 1 Protease Expressed in Escherichia coli Behaves as a Dimeric Aspartic Protease by Meek, Thomas D., Dayton, Brian D., Metcalf, Brian W., Dreyer, Geoffrey B., Strickler, James E., Gorniak, Joselina G., Rosenberg, Martin, Moore, Michael L., Magaard, Victoria W., Debouck, Christine

“…Recombinant human immunodeficiency virus 1 (HIV-1) protease, purified from a bacterial expression system, processed a recombinant form of its natural…”
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Peptide substrates and inhibitors of the HIV-1 protease by Moore, M L, Bryan, W M, Fakhoury, S A, Magaard, V W, Huffman, W F, Dayton, B D, Meek, T D, Hyland, L, Dreyer, G B, Metcalf, B W

“…Oligopeptides containing the consensus retroviral protease cleavage sequence Ser/Thr-X-Y-Tyr/Phe-Pro are substrates for purified recombinant HIV-1 protease…”
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