Search Results - "Gorman, Michael A."

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling by Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Dottore, Mara, McClure, Barbara J., Dhagat, Urmi, Taing, Houng, Gorman, Michael A., King-Scott, Jack, Lopez, Angel F., Parker, Michael W.

“…The GM-CSF, IL-3, and IL-5 receptors constitute the βc family, playing important roles in inflammation, autoimmunity, and cancer. Typical of heterodimeric type…”
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Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding by Langendorf, Christopher G., Ngoei, Kevin R. W., Scott, John W., Ling, Naomi X. Y., Issa, Sam M. A., Gorman, Michael A., Parker, Michael W., Sakamoto, Kei, Oakhill, Jonathan S., Kemp, Bruce E.

“…The metabolic stress-sensing enzyme AMP-activated protein kinase (AMPK) is responsible for regulating metabolism in response to energy supply and demand. Drugs…”
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Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins by Lawrence, Sara L., Gorman, Michael A., Feil, Susanne C., Mulhern, Terrence D., Kuiper, Michael J., Ratner, Adam J., Tweten, Rodney K., Morton, Craig J., Parker, Michael W.

“…Cholesterol-dependent cytolysins (CDCs) are a family of pore-forming toxins that punch holes in the outer membrane of eukaryotic cells. Cholesterol serves as…”
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Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography by Dickmann, Catherine G Fitzgerald, McDonald, Alexander F, Huynh, Nhi, Rigopoulos, Angela, Liu, Zhanqi, Guo, Nancy, Osellame, Laura D, Gorman, Michael A, Parker, Michael W, Gan, Hui K, Scott, Andrew M, Ackermann, Uwe, Burvenich, Ingrid J G, White, Jonathan M

“…Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. BET proteins have not been…”
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Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase by Mobbs, Jesse I, Koay, Ann, Di Paolo, Alex, Bieri, Michael, Petrie, Emma J, Gorman, Michael A, Doughty, Larissa, Parker, Michael W, Stapleton, David I, Griffin, Michael D W, Gooley, Paul R

“…AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that is important in regulating energy metabolism in all eukaryotes. The β-subunit exists in two…”
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Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target by Soares da Costa, Tatiana P., Desbois, Sebastien, Dogovski, Con, Gorman, Michael A., Ketaren, Natalia E., Paxman, Jason J., Siddiqui, Tanzeela, Zammit, Leanne M., Abbott, Belinda M., Robins-Browne, Roy M., Parker, Michael W., Jameson, Geoffrey B., Hall, Nathan E., Panjikar, Santosh, Perugini, Matthew A.

“…Dihydrodipicolinate synthase (DHDPS) catalyzes the first committed step in the lysine biosynthesis pathway of bacteria. The pathway can be regulated by…”
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QM/MM simulations provide insight into the mechanism of bioluminescence triggering in ctenophore photoproteins by Molakarimi, Maryam, Mohseni, Ammar, Taghdir, Majid, Pashandi, Zaiddodine, Gorman, Michael A, Parker, Michael W, Naderi-Manesh, Hossein, Sajedi, Reza H

“…Photoproteins are responsible for light emission in a variety of marine ctenophores and coelenterates. The mechanism of light emission in both families occurs…”
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The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin by Wade, Kristin R, Lawrence, Sara L, Farrand, Allison J, Hotze, Eileen M, Kuiper, Michael J, Gorman, Michael A, Christie, Michelle P, Panjikar, Santosh, Morton, Craig J, Parker, Michael W, Tweten, Rodney K

“…The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebrate niches, which suggests…”
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Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health by Gorman, Michael A., Seers, Christine A., Michell, Belinda J., Feil, Susanne C., Huq, N. Laila, Cross, Keith J., Reynolds, Eric C., Parker, Michael W.

“…The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the principle virulence factors of…”
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From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae by Dogovski, Con, Gorman, Michael A, Ketaren, Natalia E, Praszkier, Judy, Zammit, Leanne M, Mertens, Haydyn D, Bryant, Gary, Yang, Ji, Griffin, Michael D W, Pearce, F Grant, Gerrard, Juliet A, Jameson, Geoffrey B, Parker, Michael W, Robins-Browne, Roy M, Perugini, Matthew A

“…Given the rise in drug-resistant Streptococcus pneumoniae, there is an urgent need to discover new antimicrobials targeting this pathogen and an equally urgent…”
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A structural view of PA2G4 isoforms with opposing functions in cancer by Stevenson, Brendan W., Gorman, Michael A., Koach, Jessica, Cheung, Belamy B., Marshall, Glenn M., Parker, Michael W., Holien, Jessica K.

“…The role of proliferation-associated protein 2G4 (PA2G4), alternatively known as ErbB3-binding protein 1 (EBP1), in cancer has become apparent over the past 20…”
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Crystal structure of Alzheimer's disease phospholipase D3 provides a molecular basis for understanding its normal and pathological functions by Ishii, Kenta, Hermans, Stefan J, Georgopoulou, Maria Eleni, Nero, Tracy L, Hancock, Nancy C, Crespi, Gabriela A N, Gorman, Michael A, Gooi, Jonathan H, Parker, Michael W

“…Human 5'-3' exonuclease PLD3, a member of the phospholipase D family of enzymes, has been validated as a therapeutic target for treating Alzheimer's disease…”
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Implementation of robotic pancreaticoduodenectomy at a community tertiary care hospital utilizing a comprehensive curriculum by Heckman, Jason T., Martinez, Ashley E., Keim, Rebecca L., Mazzaferro, Sarah E., Mir, Kristin S., Gorman, Michael A., Shah, Ujas S.

“…We evaluated the outcomes of a robotic pancreaticoduodenectomy (RPD) program implemented at a community tertiary care hospital. A retrospective review of 65…”
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Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers by Fulford, Thomas S., Soliman, Caroline, Castle, Rebecca G., Rigau, Marc, Ruan, Zheng, Dolezal, Olan, Seneviratna, Rebecca, Brown, Hamish G., Hanssen, Eric, Hammet, Andrew, Li, Shihan, Redmond, Samuel J., Chung, Amy, Gorman, Michael A., Parker, Michael W., Patel, Onisha, Peat, Thomas S., Newman, Janet, Behren, Andreas, Gherardin, Nicholas A., Godfrey, Dale I., Uldrich, Adam P.

“…Butyrophilin (BTN) molecules are emerging as key regulators of T cell immunity; however, how they trigger cell-mediated responses is poorly understood. Here,…”
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Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations by Molakarimi, Maryam, Gorman, Michael A., Mohseni, Ammar, Pashandi, Zaiddodine, Taghdir, Majid, Naderi-Manesh, Hossein, Sajedi, Reza H., Parker, Michael W.

“…Bioluminescence of a variety of marine organisms, mostly cnidarians and ctenophores, is carried out by Ca2+-dependent photoproteins. The mechanism of light…”
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Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation by Lawrence, Sara L., Feil, Susanne C., Morton, Craig J., Farrand, Allison J., Mulhern, Terrence D., Gorman, Michael A., Wade, Kristin R., Tweten, Rodney K., Parker, Michael W.

“…Pore-forming proteins are weapons often used by bacterial pathogens to breach the membrane barrier of target cells. Despite their critical role in infection…”
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Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface by Koach, Jessica, Holien, Jessica K, Massudi, Hassina, Carter, Daniel R, Ciampa, Olivia C, Herath, Mika, Lim, Taylor, Seneviratne, Janith A, Milazzo, Giorgio, Murray, Jayne E, McCarroll, Joshua A, Liu, Bing, Mayoh, Chelsea, Keenan, Bryce, Stevenson, Brendan W, Gorman, Michael A, Bell, Jessica L, Doughty, Larissa, Hüttelmaier, Stefan, Oberthuer, Andre, Fischer, Matthias, Gifford, Andrew J, Liu, Tao, Zhang, Xiaoling, Zhu, Shizhen, Gustafson, W Clay, Haber, Michelle, Norris, Murray D, Fletcher, Jamie I, Perini, Giovanni, Parker, Michael W, Cheung, Belamy B, Marshall, Glenn M

“…MYCN is a major driver for the childhood cancer, neuroblastoma, however, there are no inhibitors of this target. Enhanced MYCN protein stability is a key…”
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Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase by Gunn, Natalie J., Gorman, Michael A., Dobson, Renwick C. J., Parker, Michael W., Mulhern, Terrence D.

“…The C‐terminal Src kinase (Csk) and Csk‐homologous kinase (CHK) are endogenous inhibitors of the proto‐oncogenic Src family of protein tyrosine kinases (SFKs)…”
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Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target by Atkinson, Sarah C., Dogovski, Con, Wood, Kathleen, Griffin, Michael D.W., Gorman, Michael A., Hor, Lilian, Reboul, Cyril F., Buckle, Ashley M., Wuttke, Joachim, Parker, Michael W., Dobson, Renwick C.J., Perugini, Matthew A.

“…Protein dynamics manifested through structural flexibility play a central role in the function of biological molecules. Here we explore the substrate-mediated…”
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Inhibitors of the Oncogenic PA2G4-MYCN Protein-Protein Interface by Massudi, Hassina, Luo, Jie-Si, Holien, Jessica K, Gadde, Satyanarayana, Krishan, Sukriti, Herath, Mika, Koach, Jessica, Stevenson, Brendan W, Gorman, Michael A, Venkat, Pooja, Mayoh, Chelsea, Luo, Xue-Qun, Parker, Michael W, Cheung, Belamy B, Marshall, Glenn M

“…MYCN is a major oncogenic driver for neuroblastoma tumorigenesis, yet there are no direct MYCN inhibitors. We have previously identified PA2G4 as a direct…”
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