Search Results - "Gorman, Maureen J"

Iron binding and release properties of transferrin-1 from Drosophila melanogaster and Manduca sexta: Implications for insect iron homeostasis by Weber, Jacob J., Kanost, Michael R., Gorman, Maureen J.

“…Transferrins belong to an ancient family of extracellular proteins. The best-characterized transferrins are mammalian proteins that function in iron…”
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Comparison of insect and human cytochrome b561 proteins: Insights into candidate ferric reductases in insects by Holst, Jessica D, Murphy, Laura G, Gorman, Maureen J, Ragan, Emily J

“…Cytochrome b561 (cytb561) proteins comprise a family of transmembrane oxidoreductases that transfer single electrons across a membrane. Most eukaryotic…”
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Development of a new method for collecting hemolymph and measuring phenoloxidase activity in Tribolium castaneum by Tabunoki, Hiroko, Dittmer, Neal T, Gorman, Maureen J, Kanost, Michael R

“…Hemolymph plays many important roles in the physiology of an insect throughout its lifetime; however, for small-bodied insects, studies are lacking because of…”
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Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster by Lang, Minglin, Braun, Caroline L, Kanost, Michael R, Gorman, Maureen J

“…Multicopper ferroxidases catalyze the oxidation of ferrous iron to ferric iron. In yeast and algae, they participate in cellular uptake of iron; in mammals,…”
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Iron Homeostasis in Insects by Gorman, Maureen J

“…Iron is an essential micronutrient for all types of organisms; however, iron has chemical properties that can be harmful to cells. Because iron is both…”
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Superoxide dismutase 2 knockdown leads to defects in locomotor activity, sensitivity to paraquat, and increased cuticle pigmentation in Tribolium castaneum by Tabunoki, Hiroko, Gorman, Maureen J., Dittmer, Neal T., Kanost, Michael R.

“…Insects can rapidly adapt to environmental changes through physiological responses. The red flour beetle Tribolium castaneum is widely used as a model insect…”
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Manduca sexta Hemolymph Proteinase 21 Activates Prophenoloxidase-activating Proteinase 3 in an Insect Innate Immune Response Proteinase Cascade by Gorman, Maureen J., Wang, Yang, Jiang, Haobo, Kanost, Michael R.

“…Melanization, an insect immune response, requires a set of hemolymph proteins including pathogen recognition proteins that initiate the response, a cascade of…”
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Multicopper oxidase-3 is a laccase associated with the peritrophic matrix of Anopheles gambiae by Lang, Minglin, Kanost, Michael R, Gorman, Maureen J

“…The multicopper oxidase (MCO) family of enzymes includes laccases, which oxidize a broad range of substrates including polyphenols and phenylendiamines;…”
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A multicopper oxidase-related protein is essential for insect viability, longevity and ovary development by Peng, Zeyu, Green, Peter G, Arakane, Yasuyuki, Kanost, Michael R, Gorman, Maureen J

“…Typical multicopper oxidases (MCOs) have ten conserved histidines and one conserved cysteine that coordinate four copper atoms. These copper ions are required…”
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Multicopper oxidase-1 orthologs from diverse insect species have ascorbate oxidase activity by Peng, Zeyu, Dittmer, Neal T., Lang, Minglin, Brummett, Lisa M., Braun, Caroline L., Davis, Lawrence C., Kanost, Michael R., Gorman, Maureen J.

“…Members of the multicopper oxidase (MCO) family of enzymes can be classified by their substrate specificity; for example, ferroxidases oxidize ferrous iron,…”
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Characterization of tyrosine hydroxylase from Manduca sexta by Gorman, Maureen J., An, Chunju, Kanost, Michael R.

“…In insects, 3,4-dihydroxyphenylalanine (DOPA) is required for tanning of newly formed cuticle and the production of melanin during some types of immune…”
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Manduca sexta Serpin-3 Regulates Prophenoloxidase Activation in Response to Infection by Inhibiting Prophenoloxidase-activating Proteinases by Zhu, Yifei, Wang, Yang, Gorman, Maureen J., Jiang, Haobo, Kanost, Michael R.

“…Many serine proteinase inhibitors of the serpin superfamily have evolved in vertebrates and invertebrates to regulate serine proteinase cascades that mediate…”
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Characterization of endogenous and recombinant forms of laccase-2, a multicopper oxidase from the tobacco hornworm, Manduca sexta by Dittmer, Neal T., Gorman, Maureen J., Kanost, Michael R.

“…Laccases belong to the group of multicopper oxidases that exhibit wide substrate specificity for polyphenols and aromatic amines. They are found in plants,…”
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Kinetic properties of alternatively spliced isoforms of laccase-2 from Tribolium castaneum and Anopheles gambiae by Gorman, Maureen J, Sullivan, Lucinda I, Nguyen, Thi D.T, Dai, Huaien, Arakane, Yasuyuki, Dittmer, Neal T, Syed, Lateef U, Li, Jun, Hua, Duy H, Kanost, Michael R

“…Laccase-2 is a highly conserved multicopper oxidase that functions in insect cuticle pigmentation and tanning. In many species, alternative splicing gives rise…”
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Characterization of the multicopper oxidase gene family in Anopheles gambiae by Gorman, Maureen J., Dittmer, Neal T., Marshall, Jeremy L., Kanost, Michael R.

“…The multicopper oxidase (MCO) family of enzymes includes laccases, which oxidize a broad range of substrates including diphenols, and several oxidases with…”
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Characterization of cDNAs encoding putative laccase-like multicopper oxidases and developmental expression in the tobacco hornworm, Manduca sexta, and the malaria mosquito, Anopheles gambiae by Dittmer, Neal T, Suderman, Richard J, Jiang, Haobo, Zhu, Yu-Cheng, Gorman, Maureen J, Kramer, Karl J, Kanost, Michael R

“…Laccase (EC 1.10.3.2) is an enzyme with p-diphenol oxidase activity that is a member of a group of proteins collectively known as multicopper, or blue copper,…”
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Yellow-g and Yellow-g2 proteins are required for egg desiccation resistance and temporal pigmentation in the Asian tiger mosquito, Aedes albopictus by Noh, Mi Young, Kim, Sung Hyun, Gorman, Maureen J., Kramer, Karl J., Muthukrishnan, Subbaratnam, Arakane, Yasuyuki

“…Eggs from Aedes mosquitoes exhibit desiccation resistance that helps them to survive and spread as human disease vectors throughout the world. Previous studies…”
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A conserved asparagine residue stabilizes iron binding in Manduca sexta transferrin-1 by Weber, Jacob J., Geisbrecht, Brian V., Kanost, Michael R., Gorman, Maureen J.

“…Transferrin 1 (Tsf1) is an insect-specific iron-binding protein that is abundant in hemolymph and other extracellular fluids. It binds iron tightly at neutral…”
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The immune properties of Manduca sexta transferrin by Brummett, Lisa M., Kanost, Michael R., Gorman, Maureen J.

“…Transferrins are secreted proteins that bind iron. The well-studied transferrins are mammalian serum transferrin, which is involved in iron transport, and…”
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Phenotypic analyses, protein localization, and bacteriostatic activity of Drosophila melanogaster transferrin-1 by Weber, Jacob J, Brummett, Lisa M, Coca, Michelle E, Tabunoki, Hiroko, Kanost, Michael R, Ragan, Emily J, Park, Yoonseong, Gorman, Maureen J

“…Transferrin-1 (Tsf1) is an extracellular insect protein with a high affinity for iron. The functions of Tsf1 are still poorly understood; however, Drosophila…”
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