Search Results - "Gorman, Joseph H"

Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition by Purcell, Brendan P., Lobb, David, Charati, Manoj B., Dorsey, Shauna M., Wade, Ryan J., Zellars, Kia N., Doviak, Heather, Pettaway, Sara, Logdon, Christina B., Shuman, James A., Freels, Parker D., Gorman III, Joseph H., Gorman, Robert C., Spinale, Francis G., Burdick, Jason A.

“…Inhibitors of matrix metalloproteinases (MMPs) have been extensively explored to treat pathologies where excessive MMP activity contributes to adverse tissue…”
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Injectable hydrogel properties influence infarct expansion and extent of postinfarction left ventricular remodeling in an ovine model by Ifkovits, Jamie L., Tous, Elena, Minakawa, Masahito, Morita, Masato, Robb, J. Daniel, Koomalsingh, Kevin J., Gorman, Joseph H., Gorman, Robert C., Burdick, Jason A., Langer, Robert

“…A recent trend has emerged that involves myocardial injection of biomaterials, containing cells or acellular, following myocardial infarction (MI) to influence…”
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Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model by Liu, Hao, Sacks, Michael S, Simonian, Natalie T, Gorman, 3rd, Joseph H, Gorman, Robert C

“…Ischemic mitral regurgitation (IMR) occurs from incomplete coaptation of the mitral valve (MV) after myocardial infarction (MI), typically worsened by…”
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Use of computational fluid dynamics studies in predicting aneurysmal degeneration of acute type B aortic dissections by Shang, Eric K., MD, Nathan, Derek P., MD, Fairman, Ronald M., MD, Bavaria, Joseph E., MD, Gorman, Robert C., MD, Gorman, Joseph H., MD, Jackson, Benjamin M., MD

“…Objective Whereas uncomplicated acute type B aortic dissections are often medically managed with good outcomes, a subset develop subacute or chronic aneurysmal…”
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Metabolite Exchange between Mammalian Organs Quantified in Pigs by Jang, Cholsoon, Hui, Sheng, Zeng, Xianfeng, Cowan, Alexis J., Wang, Lin, Chen, Li, Morscher, Raphael J., Reyes, Jorge, Frezza, Christian, Hwang, Ho Young, Imai, Akito, Saito, Yoshiaki, Okamoto, Keitaro, Vaspoli, Christine, Kasprenski, Loewe, Zsido, Gerald A., Gorman, Joseph H., Gorman, Robert C., Rabinowitz, Joshua D.

“…Mammalian organs continually exchange metabolites via circulation, but systems-level analysis of this shuttling process is lacking. Here, we compared, in…”
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Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains by Narang, Harshita, Rego, Bruno V., Khalighi, Amir H., Aly, Ahmed, Pouch, Alison M., Gorman, Robert C., Gorman III, Joseph H., Sacks, Michael S.

“…Ischemic mitral regurgitation (IMR) is a prevalent cardiac disease associated with substantial morbidity and mortality. Contemporary surgical treatments…”
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Injectable Shear-Thinning Hydrogels for Minimally Invasive Delivery to Infarcted Myocardium to Limit Left Ventricular Remodeling by Rodell, Christopher B, Lee, Madonna E, Wang, Hua, Takebayashi, Satoshi, Takayama, Tetsushi, Kawamura, Tomonori, Arkles, Jeffrey S, Dusaj, Neville N, Dorsey, Shauna M, Witschey, Walter R T, Pilla, James J, Gorman, 3rd, Joseph H, Wenk, Jonathan F, Burdick, Jason A, Gorman, Robert C

“…Injectable, acellular biomaterials hold promise to limit left ventricular remodeling and heart failure precipitated by infarction through bulking or stiffening…”
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In vivo assessment of mitral valve leaflet remodelling following myocardial infarction by Rego, Bruno V., Khalighi, Amir H., Lai, Eric K., Gorman, Robert C., Gorman, Joseph H., Sacks, Michael S.

“…Each year, more than 40,000 people undergo mitral valve (MV) repair surgery domestically to treat regurgitation caused by myocardial infarction (MI). Although…”
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The impact of myocardial compressibility on organ-level simulations of the normal and infarcted heart by Liu, Hao, Soares, João S., Walmsley, John, Li, David S., Raut, Samarth, Avazmohammadi, Reza, Iaizzo, Paul, Palmer, Mark, Gorman, Joseph H., Gorman, Robert C., Sacks, Michael S.

“…Myocardial infarction (MI) rapidly impairs cardiac contractile function and instigates maladaptive remodeling leading to heart failure. Patient-specific models…”
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Influence of Injectable Hyaluronic Acid Hydrogel Degradation Behavior on Infarction-Induced Ventricular Remodeling by Tous, Elena, Ifkovits, Jamie L., Koomalsingh, Kevin J., Shuto, Takashi, Soeda, Toru, Kondo, Norihiro, Gorman, Joseph H., Gorman, Robert C., Burdick, Jason A.

“…Increased myocardial wall stress after myocardial infarction (MI) initiates the process of adverse left ventricular (LV) remodeling that is manifest as…”
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Saddle Shape of the Mitral Annulus Reduces Systolic Strains on the P2 Segment of the Posterior Mitral Leaflet by Padala, Muralidhar, MS, Hutchison, Ross A., BS, Croft, Laura R., BS, Jimenez, Jorge H., PhD, Gorman, Robert C., MD, Gorman, Joseph H., MD, Sacks, Michael S., PhD, Yoganathan, Ajit P., PhD

“…Background The three-dimensional saddle shape of the mitral annulus is well characterized in animals and humans, but the impact of annular nonplanarity on…”
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In-vivo heterogeneous functional and residual strains in human aortic valve leaflets by Aggarwal, Ankush, Pouch, Alison M, Lai, Eric, Lesicko, John, Yushkevich, Paul A, Gorman III, Joseph H, Gorman, Robert C, Sacks, Michael S

“…Abstract Residual and physiological functional strains in soft tissues are known to play an important role in modulating organ stress distributions. Yet, no…”
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Acellular biomaterials: an evolving alternative to cell-based therapies by Burdick, Jason A, Mauck, Robert L, Gorman, 3rd, Joseph H, Gorman, Robert C

“…Acellular biomaterials can stimulate the local environment to repair tissues without the regulatory and scientific challenges of cell-based therapies. A…”
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Computational sensitivity investigation of hydrogel injection characteristics for myocardial support by Wang, Hua, Rodell, Christopher B., Lee, Madonna E., Dusaj, Neville N., Gorman, Joseph H., Burdick, Jason A., Gorman, Robert C., Wenk, Jonathan F.

“…Biomaterial injection is a potential new therapy for augmenting ventricular mechanics after myocardial infarction (MI). Recent in vivo studies have…”
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Mesenchymal Cell Transplantation and Myocardial Remodeling After Myocardial Infarction by DIXON, Jennifer A, GORMAN, Robert C, JOHN-SUTTON, Martin G. St, SPINALE, Francis G, STROUD, Robert E, BOUGES, Shenikqua, HIROTSUGU, Hamamoto, GORMAN, Joseph H, MARTENS, Timothy P, ITESCU, Silviu, SCHUSTER, Michael D, PLAPPERT, Theodore

“…Targeted delivery of mesenchymal precursor cells (MPCs) can modify left ventricular (LV) cellular and extracellular remodeling after myocardial infarction…”
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Age-related enhanced degeneration of bioprosthetic valves due to leaflet calcification, tissue crosslinking, and structural changes by Xue, Yingfei, Kossar, Alexander P, Abramov, Alexey, Frasca, Antonio, Sun, Mingze, Zyablitskaya, Mariya, Paik, David, Kalfa, David, Della Barbera, Mila, Thiene, Gaetano, Kozaki, Satoshi, Kawashima, Takayuki, Gorman, Joseph H, Gorman, Robert C, Gillespie, Matthew J, Carreon, Chrystalle Katte, Sanders, Stephen P, Levy, Robert J, Ferrari, Giovanni

“…Abstract Aims Bioprosthetic heart valves (BHVs), made from glutaraldehyde-fixed heterograft materials, are subject to more rapid structural valve degeneration…”
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MRI evaluation of injectable hyaluronic acid-based hydrogel therapy to limit ventricular remodeling after myocardial infarction by Dorsey, Shauna M, McGarvey, Jeremy R, Wang, Hua, Nikou, Amir, Arama, Leron, Koomalsingh, Kevin J, Kondo, Norihiro, Gorman, Joseph H, Pilla, James J, Gorman, Robert C, Wenk, Jonathan F, Burdick, Jason A

“…Abstract Injectable biomaterials are an attractive therapy to attenuate left ventricular (LV) remodeling after myocardial infarction (MI). Although studies…”
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How Local Annular Force and Collagen Density Govern Mitral Annuloplasty Ring Dehiscence Risk by Pierce, Eric L., BS, Siefert, Andrew W., PhD, Paul, Deborah M., BS, Wells, Sarah K., BS, Bloodworth, Charles H., BS, Takebayashi, Satoshi, MD, Aoki, Chikashi, MD, Jensen, Morten O., PhD, Dr.Med, Gillespie, Matthew J., MD, Gorman, Robert C., MD, Gorman, Joseph H., MD, Yoganathan, Ajit P., PhD

“…Background Annuloplasty ring dehiscence is a well described mode of mitral valve repair failure. Defining the mechanisms underlying dehiscence may facilitate…”
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Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves by Ikonomidis, John S., MD, PhD, Jones, Jeffery A., PhD, Barbour, John R., MD, Stroud, Robert E., MS, Clark, Leslie L., MS, Kaplan, Brooke S., BS, Zeeshan, Ahmed, MD, Bavaria, Joseph E., MD, Gorman, Joseph H., MD, Spinale, Francis G., MD, PhD, Gorman, Robert C., MD

“…Objective The mechanisms contributing to ascending thoracic aortic aneurysms associated with bicuspid aortic valves may differ from ascending thoracic aortic…”
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Pathogenesis of Acute Aortic Dissection: A Finite Element Stress Analysis by Nathan, Derek P., MD, Xu, Chun, PhD, Gorman, Joseph H., MD, Fairman, Ron M., MD, Bavaria, Joseph E., MD, Gorman, Robert C., MD, Chandran, Krishnan B., PhD, Jackson, Benjamin M., MD

“…Background Type A and type B aortic dissections typically result from intimal tears above the sinotubular junction and distal to the left subclavian artery…”
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