Search Results - "Gorlová, Olga"

Influence of active pharmaceutical ingredient structures on Hansen solubility parameters by Petříková, Eva, Patera, Jan, Gorlová, Olga

“…•Hansen solubility parameters were determined via inverse gas chromatography using Snyder and Karger adsorption model.•Results from experimental measurements…”
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Strength of selection in lung tumors correlates with clinical features better than tumor mutation burden by Gorlov, Ivan P., Gorlova, Olga Y., Tsavachidis, Spyridon, Amos, Christopher I.

“…Single nucleotide substitutions are the most common type of somatic mutations in cancer genome. The goal of this study was to use publicly available somatic…”
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SNP characteristics and validation success in genome wide association studies by Gorlova, Olga Y., Xiao, Xiangjun, Tsavachidis, Spiridon, Amos, Christopher I., Gorlov, Ivan P.

“…Genome wide association studies (GWASs) have identified tens of thousands of single nucleotide polymorphisms (SNPs) associated with human diseases and…”
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Effect of the different types of Sn-precursors on the properties of Sn FeMgAl-LDH samples by Tišler, Zdeněk, Peroutková, Kateřina, Gorlová, Olga, Strejcová, Kateřina, Kocík, Jaroslav, Šimek, Josef, Paterová, Iva

“…In this work, LDH SnFeMgAl were prepared by co-precipitation method at constant temperature and pH using different Sn precursors. Calcined and LDHs samples…”
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Calculated indices of volatile organic compounds (VOCs) in exhalation for lung cancer screening and early detection by Chen, Xing, Muhammad, Kanhar Ghulam, Madeeha, Channa, Fu, Wei, Xu, Linxin, Hu, Yanjie, Liu, Jun, Ying, Kejing, Chen, Liying, Yurievna, Gorlova Olga

“…•Breath Analysis is promising no invasive technique.•VOC profile Help distinguish early stage lung cancer from advanced stage lung cancer.•VOC profile helps…”
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Shifting Paradigm of Association Studies: Value of Rare Single-Nucleotide Polymorphisms by Gorlov, Ivan P., Gorlova, Olga Y., Sunyaev, Shamil R., Spitz, Margaret R., Amos, Christopher I.

“…Currently, single-nucleotide polymorphisms (SNPs) with minor allele frequency (MAF) of >5% are preferentially used in case-control association studies of…”
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Association of Smoking with Metabolic Volatile Organic Compounds in Exhaled Breath by Chen, Xing, Wang, Fuyuan, Lin, Liquan, Dong, Hao, Huang, Feifei, Ghulam Muhammad, Kanhar, Chen, Liying, Gorlova, Olga Y

“…Lung cancer (LC) screening will be more efficient if it is applied to a well-defined high-risk population. Characteristics including metabolic byproducts may…”
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Allelic Spectra of Risk SNPs Are Different for Environment/Lifestyle Dependent versus Independent Diseases by Gorlov, Ivan P, Gorlova, Olga Y, Amos, Christopher I

“…Genome-wide association studies (GWAS) have generated sufficient data to assess the role of selection in shaping allelic diversity of disease-associated SNPs…”
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Associations between dietary intake of choline and betaine and lung cancer risk by Ying, Jun, Rahbar, Mohammad H, Hallman, D Michael, Hernandez, Ladia M, Spitz, Margret R, Forman, Michele R, Gorlova, Olga Y

“…Evidence from human and animal research indicates that choline metabolic pathways may be activated during a variety of diseases, including cancer. We report…”
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Structural Motifs in Cold Ternary Ion Complexes of Hydroxyl-Functionalized Ionic Liquids: Isolating the Role of Cation–Cation Interactions by Menges, Fabian S, Zeng, Helen J, Kelleher, Patrick J, Gorlova, Olga, Johnson, Mark A, Niemann, Thomas, Strate, Anne, Ludwig, Ralf

“…We address the competition between intermolecular forces underlying the recent observation that ionic liquids (ILs) with a hydroxyl-functionalized cation can…”
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Tumor somatic mutations also existing as germline polymorphisms may help to identify functional SNPs from genome-wide association studies by Gorlov, Ivan P, Xia, Xiangjun, Tsavachidis, Spiridon, Gorlova, Olga Y, Amos, Christopher I

“…Abstract We hypothesized that a joint analysis of cancer risk-associated single-nucleotide polymorphism (SNP) and somatic mutations in tumor samples can…”
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Identification of lung cancer drivers by comparison of the observed and the expected numbers of missense and nonsense mutations in individual human genes by Gorlova, Olga Y, Kimmel, Marek, Tsavachidis, Spiridon, Amos, Christopher I, Gorlov, Ivan P

“…Largely, cancer development is driven by acquisition and positive selection of somatic mutations that increase proliferation and survival of tumor cells. As a…”
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Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples by Gorlov, Ivan P, Pikielny, Claudio W, Frost, Hildreth R, Her, Stephanie C, Cole, Michael D, Strohbehn, Samuel D, Wallace-Bradley, David, Kimmel, Marek, Gorlova, Olga Y, Amos, Christopher I

“…Because driver mutations provide selective advantage to the mutant clone, they tend to occur at a higher frequency in tumor samples compared to selectively…”
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Impact of Reduced Tobacco Smoking on Lung Cancer Mortality in the United States During 1975―2000 by MOOLGAVKAR, Suresh H, HOLFORD, Theodore R, MCCARTHY, William, BOER, Robert, GORLOVA, Olga, SCOTT GAZELLE, G, KIMMEL, Marek, MCMAHON, Pamela M, DE KONING, Harry J, FEUER, Eric J, LEVY, David T, CHUNG YIN KONG, FOY, Millenia, CLARKE, Lauren, JEON, Jihyoun, HAZELTON, William D, MEZA, Rafael, SCHULTZ, Frank

“…Considerable effort has been expended on tobacco control strategies in the United States since the mid-1950s. However, we have little quantitative information…”
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Modeling the natural history and detection of lung cancer based on smoking behavior by Chen, Xing, Foy, Millennia, Kimmel, Marek, Gorlova, Olga Y

“…In this study, we developed a method for modeling the progression and detection of lung cancer based on the smoking behavior at an individual level. The model…”
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Genetics of Smoking Behaviors in American Indians by Henderson, Jeffrey A, Buchwald, Dedra S, Howard, Barbara V, Henderson, Patricia Nez, Li, Yafang, Tyndale, Rachel F, Amos, Christopher I, Gorlova, Olga Y

“…The smoking behavior of American Indians (AI) differs from that of non-Hispanic whites (NHW). Typically light smokers, cessation interventions in AIs are…”
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Downstream targets of GWAS-detected genes for breast, lung, and prostate and colon cancer converge to G1/S transition pathway by Gorlova, Olga Y, Demidenko, Eugene I, Amos, Christopher I, Gorlov, Ivan P

“…Genome-wide association studies (GWASs) identified over 500 single nucleotide polymorphisms (SNPs) influencing cancer risk. It is logical to expect the…”
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Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations by Gorlova, Olga Y, Li, Yafang, Gorlov, Ivan, Ying, Jun, Chen, Wei V, Assassi, Shervin, Reveille, John D, Arnett, Frank C, Zhou, Xiaodong, Bossini-Castillo, Lara, Lopez-Isac, Elena, Acosta-Herrera, Marialbert, Gregersen, Peter K, Lee, Annette T, Steen, Virginia D, Fessler, Barri J, Khanna, Dinesh, Schiopu, Elena, Silver, Richard M, Molitor, Jerry A, Furst, Daniel E, Kafaja, Suzanne, Simms, Robert W, Lafyatis, Robert A, Carreira, Patricia, Simeon, Carmen Pilar, Castellvi, Ivan, Beltran, Emma, Ortego, Norberto, Amos, Christopher I, Martin, Javier, Mayes, Maureen D

“…Gene-level analysis of ImmunoChip or genome-wide association studies (GWAS) data has not been previously reported for systemic sclerosis (SSc, scleroderma)…”
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Methylation of nonessential genes in cutaneous melanoma – Rule Out hypothesis by Gorlov, Ivan P., Conway, Kathleen, Edmiston, Sharon N., Parrish, Eloise A., Hao, Honglin, Amos, Christopher I., Tsavachidis, Spiridon, Gorlova, Olga Y., Begg, Colin, Hernando, Eva, Cheng, Chao, Shen, Ronglai, Orlow, Irene, Luo, Li, Ernstoff, Marc S., Kuan, Pei Fen, Ollila, David W., Tsai, Yihsuan S., Berwick, Marianne, Thomas, Nancy E.

“…Differential methylation plays an important role in melanoma development and is associated with survival, progression and response to treatment. However, the…”
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Human genes differ by their UV sensitivity estimated through analysis of UV‐induced silent mutations in melanoma by Gorlov, Ivan P., Amos, Christopher I., Tsavachidis, Spiridon, Begg, Colin, Hernando, Eva, Cheng, Chao, Shen, Ronglai, Orlow, Irene, Luo, Li, Ernstoff, Marc S., Parker, Joel, Thomas, Nancy E., Gorlova, Olga Y., Berwick, Marianne

“…We hypothesized that human genes differ by their sensitivity to ultraviolet (UV) exposure. We used somatic mutations detected by genome‐wide screens in…”
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