Search Results - "Gorla, Suresh Kumar"

Structure–activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH by Kirubakaran, Sivapriya, Gorla, Suresh Kumar, Sharling, Lisa, Zhang, Minjia, Liu, Xiaoping, Ray, Soumya S., MacPherson, Iain S., Striepen, Boris, Hedstrom, Lizbeth, Cuny, Gregory D.

“…Cryptosporidium parasites are important waterborne pathogens of both humans and animals. The Cryptosporidium parvum and Cryptosporidium hominis genomes…”
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Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase by Gorla, Suresh Kumar, Kavitha, Mandapati, Zhang, Minjia, Chin, James En Wai, Liu, Xiaoping, Striepen, Boris, Makowska-Grzyska, Magdalena, Kim, Youngchang, Joachimiak, Andrzej, Hedstrom, Lizbeth, Cuny, Gregory D

“…Cryptosporidium parvum is an enteric protozoan parasite that has emerged as a major cause of diarrhea, malnutrition, and gastroenteritis and poses a potential…”
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Validation of IMP Dehydrogenase Inhibitors in a Mouse Model of Cryptosporidiosis by SURESH KUMAR GORLA, MCNAIR, Nina N, HEDSTROM, Lizbeth, GUANGYI YANG, SONG GAO, MING HU, JALA, Venkatakrishna R, HARIBABU, Bodduluri, STRIEPEN, Boris, CUNY, Gregory D, MEAD, Jan R

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds by Makowska-Grzyska, Magdalena, Kim, Youngchang, Gorla, Suresh Kumar, Wei, Yang, Mandapati, Kavitha, Zhang, Minjia, Maltseva, Natalia, Modi, Gyan, Boshoff, Helena I, Gu, Minyi, Aldrich, Courtney, Cuny, Gregory D, Hedstrom, Lizbeth, Joachimiak, Andrzej

“…Tuberculosis (TB) remains a worldwide problem and the need for new drugs is increasingly more urgent with the emergence of multidrug- and extensively-drug…”
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Repurposing Cryptosporidium Inosine 5′-Monophosphate Dehydrogenase Inhibitors as Potential Antibacterial Agents by Mandapati, Kavitha, Gorla, Suresh Kumar, House, Amanda L, McKenney, Elizabeth S, Zhang, Minjia, Rao, Suraj Nagendra, Gollapalli, Deviprasad R, Mann, Barbara J, Goldberg, Joanna B, Cuny, Gregory D, Glomski, Ian J, Hedstrom, Lizbeth

“…Inosine 5′-monophosphate dehydrogenase (IMPDH) catalyzes the pivotal step in guanine nucleotide biosynthesis. IMPDH is a target for immunosuppressive,…”
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A Novel Cofactor-binding Mode in Bacterial IMP Dehydrogenases Explains Inhibitor Selectivity by Makowska-Grzyska, Magdalena, Kim, Youngchang, Maltseva, Natalia, Osipiuk, Jerzy, Gu, Minyi, Zhang, Minjia, Mandapati, Kavitha, Gollapalli, Deviprasad R., Gorla, Suresh Kumar, Hedstrom, Lizbeth, Joachimiak, Andrzej

“…The steadily rising frequency of emerging diseases and antibiotic resistance creates an urgent need for new drugs and targets. Inosine 5′-monophosphate…”
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Selective and Potent Urea Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase by Gorla, Suresh Kumar, Kavitha, Mandapati, Zhang, Minjia, Liu, Xiaoping, Sharling, Lisa, Gollapalli, Deviprasad R, Striepen, Boris, Hedstrom, Lizbeth, Cuny, Gregory D

“…Cryptosporidium parvum and related species are zoonotic intracellular parasites of the intestine. Cryptosporidium is a leading cause of diarrhea in small…”
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Phthalazinone inhibitors of inosine-5′-monophosphate dehydrogenase from Cryptosporidium parvum by Johnson, Corey R., Gorla, Suresh Kumar, Kavitha, Mandapati, Zhang, Minjia, Liu, Xiaoping, Striepen, Boris, Mead, Jan R., Cuny, Gregory D., Hedstrom, Lizbeth

“…Cryptosporidium parvum (Cp) is a potential biowarfare agent and major cause of diarrhea and malnutrition. This protozoan parasite relies on inosine…”
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The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity by MacPherson, Iain S, Kirubakaran, Sivapriya, Gorla, Suresh Kumar, Riera, Thomas V, D’Aquino, J. Alejandro, Zhang, Minjia, Cuny, Gregory D, Hedstrom, Lizbeth

“…Cryptosporidium parvum is a potential biowarfare agent, an important AIDS pathogen, and a major cause of diarrhea and malnutrition. No vaccines or effective…”
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Benzoxazoles, Phthalazinones, and Arylurea-Based Compounds with IMP Dehydrogenase-Independent Antibacterial Activity against Francisella tularensis by Gorla, Suresh Kumar, Zhang, Yan, Rabideau, Meaghan M, Qin, Aiping, Chacko, Shibin, House, Amanda L, Johnson, Corey R, Mandapati, Kavitha, Bernstein, Hannah M, McKenney, Elizabeth S, Boshoff, Helena, Zhang, Minjia, Glomski, Ian J, Goldberg, Joanna B, Cuny, Gregory D, Mann, Barbara J, Hedstrom, Lizbeth

“…is the causative agent of tularemia and a potential biowarfare agent. The virulence of is decreased by deletion of , the gene encoding IMP dehydrogenase…”
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Amino Derivatives of Indole As Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase by Go, Mei-Lin, Leow, Jo Lene, Gorla, Suresh Kumar, Schüller, Andreas Peter, Wang, Mei, Casey, Patrick J

“…The enzyme isoprenylcysteine carboxyl methyltransferase (Icmt) plays an important role in the post-translational modification of proteins that are involved in…”
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Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity by Kim, Youngchang, Makowska-Grzyska, Magdalena, Gorla, Suresh Kumar, Gollapalli, Deviprasad R., Cuny, Gregory D., Joachimiak, Andrzej, Hedstrom, Lizbeth

“…Inosine 5′‐monophosphate dehydrogenase (IMPDH) is a promising target for the treatment of Cryptosporidium infections. Here, the structure of C. parvum IMPDH…”
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Novel cis– trans enantiomeric conglomerates: triage and absolute configurations via anomalous X-ray scattering. A photochemical second order asymmetric transformation by Chandrasekhar, Sosale, Gorla, Suresh Kumar

“…Three tricyclic imides were prepared by a Diels–Alder reaction of 6-arylfulvenes and maleic anhydride, followed by treatment with NH 3. The exo isomers were…”
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Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity by Kim, Youngchang, Makowska-Grzyska, Magdalena, Gorla, Suresh Kumar, Gollapalli, Deviprasad R., Cuny, Gregory D., Joachimiak, Andrzej, Hedstrom, Lizbeth

“…Inosine 5'-monophosphate dehydrogenase (IMPDH) is a promising target for the treatment ofCryptosporidiuminfections. Here, the structure ofC. parvumIMPDH…”
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Analogues of cysmethynil that demonstrate improved isoprenylcysteine carboxymethyltransferase (Icmt) inhibition activity and antiproliferative activity in MDA‐MB‐231 breast cancer cells by Leow, Jo Lene, Gorla, Suresh Kumar, Wang, Mei, Casey, Patrick J, Go, Mei‐Lin

“…Abstract only…”
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Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds: e0138976 by Makowska-Grzyska, Magdalena, Kim, Youngchang, Gorla, Suresh Kumar, Wei, Yang, Mandapati, Kavitha, Zhang, Minjia, Maltseva, Natalia, Modi, Gyan, Boshoff, Helena I, Gu, Minyi

“…Tuberculosis (TB) remains a worldwide problem and the need for new drugs is increasingly more urgent with the emergence of multidrug- and extensively-drug…”
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The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity by MacPherson, Iain S, Kirubakaran, Sivapriya, Gorla, Suresh Kumar, Riera, Thomas V, D’Aquino, J. Alejandro, Zhang, Minjia, Cuny, Gregory D, Hedstrom, Lizbeth

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Correction to Repurposing Cryptosporidium Inosine 5′-Monophosphate Dehydrogenase Inhibitors as Potential Antibacterial Agents by Mandapati, Kavitha, Gorla, Suresh Kumar, House, Amanda L, McKenney, Elizabeth S, Zhang, Minjia, Rao, Suraj Nagendra, Gollapalli, Deviprasad R, Mann, Barbara J, Goldberg, Joanna B, Cuny, Gregory D, Glomski, Ian J, Hedstrom, Lizbeth

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cis–trans Enantiomerism in the Diels–Alder cycloadducts of 6-arylfulvenes with maleic anhydride: resolution of the exo adducts via the N-((1S)-1-(naphth-1-yl)ethyl)imide derivatives: assignment of the absolute configurations based on the crystal structure of an imide diastereomer by Chandrasekhar, Sosale, Gorla, Suresh Kumar

“…A new case of the uncommon cis–trans enantiomerism is presented. The titled anhydride adducts were prepared in good yields by the known reaction of three…”
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Structural Determinants of Inhibitor Selectivity in Prokaryotic IMP Dehydrogenases by Gollapalli, Deviprasad R., MacPherson, Iain S., Liechti, George, Gorla, Suresh Kumar, Goldberg, Joanna B., Hedstrom, Lizbeth

“…The protozoan parasite Cryptosporidium parvum is a major cause of gastrointestinal disease; no effective drug therapy exists to treat this infection…”
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