Search Results - "Gorin, Yves"

Aiding and abetting roles of NOX oxidases in cellular transformation by Block, Karen, Gorin, Yves

“…Key Points As early as 1981, it was suggested that enzymes biochemically similar to the NADPH oxidase (NOX) NOX2 were present in all cell types, not just in…”
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Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease by Gorin, Yves

“…Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22(phox) mediate the increase in oxidative stress and human tubular epithelial…”
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Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases by Barnes, Jeffrey L., Gorin, Yves

“…Progression of fibrosis involves interstitial hypercellularity, matrix accumulation, and atrophy of epithelial structures, resulting in loss of normal function…”
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Nox as a target for diabetic complications by Gorin, Yves, Block, Karen

“…Oxidative stress has been linked to the pathogenesis of the major complications of diabetes in the kidney, the heart, the eye or the vasculature. NADPH…”
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Subcellular localization of Nox4 and regulation in diabetes by Block, Karen, Gorin, Yves, Abboud, Hanna E

“…Oxidative stress is implicated in human diseases. Some of the oxidative pathways are harbored in the mitochondria. NAD(P)H oxidases have been identified not…”
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Pathophysiology of gadolinium-associated systemic fibrosis by Wagner, Brent, Drel, Viktor, Gorin, Yves

“…Systemic fibrosis from gadolinium-based magnetic resonance imaging contrast is a scourge for the afflicted. Although gadolinium-associated systemic fibrosis is…”
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Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases by Gorin, Yves, Eid, Assaad, Eid, Ali H., Pasha, Mazhar, Munusamy, Shankar

“…Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against…”
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RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species by Manickam, Nagaraj, Patel, Mandakini, Griendling, Kathy K, Gorin, Yves, Barnes, Jeffrey L

“…The small G proteins Rac1 and RhoA regulate actin cytoskeleton, cell shape, adhesion, migration, and proliferation. Recent studies in our laboratory have shown…”
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Sestrin 2 and AMPK Connect Hyperglycemia to Nox4-Dependent Endothelial Nitric Oxide Synthase Uncoupling and Matrix Protein Expression by Eid, Assaad A., Lee, Doug-Yoon, Roman, Linda J., Khazim, Khaled, Gorin, Yves

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes by Eid, Assaad A., Ford, Bridget M., Block, Karen, Kasinath, Balakuntalam S., Gorin, Yves, Ghosh-Choudhury, Goutam, Barnes, Jeffrey L., Abboud, Hanna E.

“…Diabetes and high glucose (HG) increase the generation of NADPH oxidase-derived reactive oxygen species and induce apoptosis of glomerular epithelial cells…”
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Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes by Maalouf, Rita M, Eid, Assaad A, Gorin, Yves C, Block, Karen, Escobar, Gladys Patricia, Bailey, Steven, Abboud, Hanna E

“…Oxidative stress contributes to diabetic cardiomyopathy. This study explored the role of the NADPH oxidase Nox4 as a source of reactive oxygen species (ROS)…”
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Activation of AMP-Activated Protein Kinase Prevents TGF-β1–Induced Epithelial-Mesenchymal Transition and Myofibroblast Activation by Thakur, Sachin, Viswanadhapalli, Suryavathi, Kopp, Jeffrey B, Shi, Qian, Barnes, Jeffrey L, Block, Karen, Gorin, Yves, Abboud, Hanna E

“…Transforming growth factor (TGF)-β contributes to tubulointerstitial fibrosis. We investigated the mechanism by which TGF-β exerts its profibrotic effects and…”
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Mammalian Target of Rapamycin Regulates Nox4-Mediated Podocyte Depletion in Diabetic Renal Injury by EID, Assaad A, FORD, Bridget M, BHANDARY, Basant, DE CASSIA CAVAGLIERI, Rita, BLOCK, Karen, BARNES, Jeffrey L, GORIN, Yves, GOUTAM GHOSH CHOUDHURY, ABBOUD, Hanna E

“…Podocyte apoptosis is a critical mechanism for excessive loss of urinary albumin that eventuates in kidney fibrosis. Pharmacological doses of the mammalian…”
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Src tyrosine kinase mediates platelet-derived growth factor BB-induced and redox-dependent migration in metanephric mesenchymal cells by Wagner, Brent, Gorin, Yves

“…The adult kidney is derived from the interaction between the metanephric blastema and the ureteric bud. Platelet-derived growth factor (PDGF) receptor β is…”
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Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression by Das, Falguni, Ghosh-Choudhury, Nandini, Lee, Doug Yoon, Gorin, Yves, Kasinath, Balakuntalam S, Choudhury, Goutam Ghosh

“…TGFβ promotes podocyte hypertrophy and expression of matrix proteins in fibrotic kidney diseases such as diabetic nephropathy. Both mTORC1 and mTORC2 are…”
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Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production by Fitzgerald, John P, Nayak, Bijaya, Shanmugasundaram, Karthigayan, Friedrichs, William, Sudarshan, Sunil, Eid, Assaad A, DeNapoli, Thomas, Parekh, Dipen J, Gorin, Yves, Block, Karen

“…Inflammatory cytokines are detected in the plasma of patients with renal cell carcinoma (RCC) and are associated with poor prognosis. However, the primary cell…”
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Symmetric dimethylarginine alters endothelial nitric oxide activity in glomerular endothelial cells by Feliers, Denis, Lee, Duck-Yoon, Gorin, Yves, Kasinath, Balakuntalam S.

“…Circulating symmetric dimethylarginine (SDMA) is increased in patients with chronic kidney disease. SDMA is considered an inert metabolite, but because it can…”
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ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice by Ford, Bridget M, Eid, Assaad A, Göőz, Monika, Barnes, Jeffrey L, Gorin, Yves C, Abboud, Hanna E

“…Matrix protein accumulation is a prominent feature of diabetic nephropathy that contributes to renal fibrosis and decline in renal function. The pathogenic…”
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Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes by Graham, Sarabeth, Gorin, Yves, Abboud, Hanna E, Ding, Min, Lee, Duck Yoon, Shi, Honglian, Ding, Yanfeng, Ma, Rong

“…The present study was performed to investigate the underlying mechanism, particularly the roles of reactive oxygen species (ROS) and protein kinase C (PKC), in…”
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Upstream Regulators and Downstream Effectors of NADPH Oxidases as Novel Therapeutic Targets for Diabetic Kidney Disease by Gorin, Y., University of Texas Health Science Center, San Antonio, USA, Wauquier, F., University of Texas Health Science Center, San Antonio, USA

“…Oxidative stress has been linked to the pathogenesis of diabetic nephropathy, the complication of diabetes in the kidney. NADPH oxidases of the Nox family, and…”
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