Search Results - "Gorijala, Priyanka"

Gene co-expression changes underlying the functional connectomic alterations in Alzheimer's disease by He, Bing, Gorijala, Priyanka, Xie, Linhui, Cao, Sha, Yan, Jingwen

“…There is growing evidence indicating that a number of functional connectivity networks are disrupted at each stage of the full clinical Alzheimer's disease…”
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Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease by Wang, Lihua, Nykänen, Niko-Petteri, Western, Daniel, Gorijala, Priyanka, Timsina, Jigyasha, Li, Fuhai, Wang, Zhaohua, Ali, Muhammad, Yang, Chengran, Liu, Menghan, Brock, William, Marquié, Marta, Boada, Mercè, Alvarez, Ignacio, Aguilar, Miquel, Pastor, Pau, Ruiz, Agustín, Puerta, Raquel, Orellana, Adelina, Rutledge, Jarod, Oh, Hamilton, Greicius, Michael D, Le Guen, Yann, Perrin, Richard J, Wyss-Coray, Tony, Jefferson, Angela, Hohman, Timothy J, Graff-Radford, Neill, Mori, Hiroshi, Goate, Alison, Levin, Johannes, Sung, Yun Ju, Cruchaga, Carlos

“…Triggering receptor expressed on myeloid cells 2 (TREM2) plays a critical role in microglial activation, survival, and apoptosis, as well as in Alzheimer's…”
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Integrative analysis of eQTL and GWAS summary statistics reveals transcriptomic alteration in Alzheimer brains by Varathan, Pradeep, Gorijala, Priyanka, Jacobson, Tanner, Chasioti, Danai, Nho, Kwangsik, Risacher, Shannon L, Saykin, Andrew J, Yan, Jingwen

“…Large-scale genome-wide association studies have successfully identified many genetic variants significantly associated with Alzheimer's disease (AD), such as…”
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TOPMed imputed genomics enhances genomic atlas of the human proteome in brain, cerebrospinal fluid, and plasma by Yi, Heng, Yang, Qijun, Repaci, Charlie, Lee, Cheolmin Matthew, Heo, Gyujin, Timsina, Jigyasha, Gorijala, Priyanka, Yang, Chengran, Budde, John, Wang, Lihua, Cruchaga, Carlos, Sung, Yun Ju

“…Comprehensive expression quantitative trait loci studies have been instrumental for understanding tissue-specific gene regulation and pinpointing functional…”
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Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease by Phillips, Bridget, Western, Daniel, Wang, Lihua, Timsina, Jigyasha, Sun, Yichen, Gorijala, Priyanka, Yang, Chengran, Do, Anh, Nykänen, Niko-Petteri, Alvarez, Ignacio, Aguilar, Miquel, Pastor, Pau, Morris, John C., Schindler, Suzanne E., Fagan, Anne M., Puerta, Raquel, García-González, Pablo, de Rojas, Itziar, Marquié, Marta, Boada, Mercè, Ruiz, Agustin, Perlmutter, Joel S., Ibanez, Laura, Perrin, Richard J., Sung, Yun Ju, Cruchaga, Carlos

“…Common and rare variants in the LRRK2 locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels…”
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Genetic architecture of plasma Alzheimer’s disease biomarkers by Bradley, Joseph, Gorijala, Priyanka, Schindler, Suzanne E., Sung, Yun Ju, Mafimoghaddam, Samira, Wang, Fengxian, Cruchaga, Carlos

“…Background Case‐control genome‐wide association studies (GWAS) have identified loci associated with risk for Alzheimer disease (AD), but they require very…”
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Genetic analyses of the plasma proteome and metabolome in the same cohort from participants with African and European ancestry identify ancestry‐specific AD risk associated molecular traits by Yang, Chengran, Gorijala, Priyanka, Timsina, Jigyasha, Wang, Lihua, Wang, Ciyang, Liu, Ellen, Morris, John C, Sung, Yun Ju, Cruchaga, Carlos

“…Background Alzheimer disease (AD) has different prevalence across different ancestries. However, the genetic factors underlying AD pathogenesis between diverse…”
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Alzheimer’s polygenic risk score is associated with Dementia and memory phenotypes in Down syndrome by Gorijala, Priyanka, Aslam, Muhammad Muaaz, Dang, Lam‐Ha, Fernandez, Victoria, Sung, Yun Ju, Fan, Kang‐Hsien, Feingold, Eleanor, Kamboh, M. Ilyas, Lee, Joseph H., Cruchaga, Carlos

“…Background Down syndrome (DS) is a complex neurological disorder manifested by triplication of chromosome 21, which includes the amyloid precursor protein…”
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Genetic architecture of plasma Alzheimer disease biomarkers by Bradley, Joseph, Gorijala, Priyanka, Schindler, Suzanne E, Sung, Yun J, Ances, Beau, Fernandez, Maria V, Cruchaga, Carlos

“…Abstract Genome-wide association studies (GWAS) of cerebrospinal fluid (CSF) Alzheimer’s Disease (AD) biomarker levels have identified novel genes implicated…”
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CSF proteo‐genomic studies identify an interaction between LRRK2 genetic variants and GRN, GPNMB, CTSB, and ENTPD1 by Wang, Lihua, Yang, Chengran, Mafimoghaddam, Samira, Timsina, Jigyasha, Gorijala, Priyanka, Wang, Fengxian, Alvarez, Ignacio, Aguilar, Miquel, Ruiz, Agustin, Pastor, Pau, Sung, Yun Ju, Cruchaga, Carlos

“…Background Parkinson’s disease (PD) is a movement disorder characterized by dopaminergic neurodegeneration in the substantia nigra of the brain. Another…”
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Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease by Rutledge, Jarod, Lehallier, Benoit, Zarifkar, Pardis, Losada, Patricia Moran, Shahid-Besanti, Marian, Western, Dan, Gorijala, Priyanka, Ryman, Sephira, Yutsis, Maya, Deutsch, Gayle K., Mormino, Elizabeth, Trelle, Alexandra, Wagner, Anthony D., Kerchner, Geoffrey A., Tian, Lu, Cruchaga, Carlos, Henderson, Victor W., Montine, Thomas J., Borghammer, Per, Wyss-Coray, Tony, Poston, Kathleen L.

“…Parkinson’s disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular biomarkers for…”
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Integrative analysis of eQTL and GWAS summary statistics reveals novel genes related to Alzheimer's disease by Varathan, Pradeep, Gorijala, Priyanka, Jacobson, Tanner Y., Nho, Kwangsik, Risacher, Shannon L., Saykin, Andrew J., Yan, Jingwen

“…Background Large‐scale genome wide association studies (GWASs) have identified many genetic variants associated with Alzheimer’s disease (AD) and related…”
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A genetic and proteomic comparison of key AD biomarkers across tissues by Marsh, Thomas W., Western, Daniel, Timsina, Jigyasha, Gorijala, Priyanka, Yang, Chengran, Pastor, Pau, Liu, Menghan, Morris, John C., Bateman, Randall J., Schindler, Suzanne E., Sung, Yun Ju, Cruchaga, Carlos

“…INTRODUCTION Plasma has been proposed as an alternative to cerebrospinal fluid (CSF) for measuring Alzheimer's disease (AD) biomarkers, but no studies have…”
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Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits by Wang, Ciyang, Yang, Chengran, Western, Daniel, Ali, Muhammad, Wang, Yueyao, Phuah, Chia-Ling, Budde, John, Wang, Lihua, Gorijala, Priyanka, Timsina, Jigyasha, Ruiz, Agustin, Pastor, Pau, Fernandez, Maria Victoria, Perrin, Richard, Panyard, Daniel J., Engelman, Corinne D., Deming, Yuetiva, Boada, Merce, Cano, Amanda, Garcia-Gonzalez, Pablo, Graff-Radford, Neill R., Mori, Hiroshi, Lee, Jae-Hong, Perrin, Richard J., Ibanez, Laura, Sung, Yun Ju, Cruchaga, Carlos

“…Brain metabolism perturbation can contribute to traits and diseases. We conducted a genome-wide association study for cerebrospinal fluid (CSF) and brain…”
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Proteo‐genomics of soluble TREM2 in cerebrospinal fluid provides novel insights for TREM2 biology and identifies novel modulators for Alzheimer’s disease by Wang, Lihua, Nykanen, Niko‐Petteri, Western, Daniel, Gorijala, Priyanka, Timsina, Jigyasha, Marquié, Marta, Boada, Mercè, Alvarez, Ignacio, Aguilar, Miquel, Pastor, Pau, Ruiz, Agustin, Hohman, Timothy J., Wyss‐Coray, Tony, Sung, Yun Ju, Cruchaga, Carlos

“…Background Triggering receptor expressed on myeloid cells 2 (TREM2) plays a critical role in microglial activation, survival, and apoptosis, as well as in…”
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GWAS for CSF TREM2 levels identify new variants implicated on TREM2 biology and Alzheimer disease by Mafimoghaddam, Samira, Wang, Lihua, Gorijala, Priyanka, Timsina, Jigyasha, Nykanen, Niko, Wang, Fengxian, Marquié, Marta, Boada, Mercè, Alvarez, Ignacio, Aguilar, Miquel, Pastor, Pau, Ruiz, Agustín, Sung, Yun Ju, Cruchaga, Carlos

“…Background It is demonstrated that the soluble TREM2 in the cerebrospinal fluid (CSF) is associated with Alzheimer disease (AD). Recent studies by our group…”
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Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer’s disease by Western, Daniel, Timsina, Jigyasha, Wang, Lihua, Wang, Ciyang, Yang, Chengran, Phillips, Bridget, Wang, Yueyao, Liu, Menghan, Ali, Muhammad, Beric, Aleksandra, Gorijala, Priyanka, Kohlfeld, Pat, Budde, John, Levey, Allan I., Morris, John C., Perrin, Richard J., Ruiz, Agustin, Marquié, Marta, Boada, Mercè, de Rojas, Itziar, Rutledge, Jarod, Oh, Hamilton, Wilson, Edward N., Le Guen, Yann, Reus, Lianne M., Tijms, Betty, Visser, Pieter Jelle, van der Lee, Sven J., Pijnenburg, Yolande A. L., Teunissen, Charlotte E., del Campo Milan, Marta, Alvarez, Ignacio, Aguilar, Miquel, Greicius, Michael D., Pastor, Pau, Pulford, David J., Ibanez, Laura, Wyss-Coray, Tony, Sung, Yun Ju, Cruchaga, Carlos

“…The integration of quantitative trait loci (QTLs) with disease genome-wide association studies (GWASs) has proven successful in prioritizing candidate genes at…”
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Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease by Phillips, Bridget, Western, Daniel, Wang, Lihua, Timsina, Jigyasha, Sun, Yichen, Gorijala, Priyanka, Yang, Chengran, Do, Anh, Nykanen, Niko‐Petteri, Alvarez, Ignacio, Aguilar, Miquel, Pastor, Pau, Morris, John C, Schindler, Suzanne E., Fagan, Anne M., Puerta, Raquel, García‐González, Pablo, de Rojas, Itziar, Marquié, Marta, Boada, Mercè, Ruiz, Agustin, Perlmutter, Joel S., Ibanez, Laura, Perrin, Richard J., Sung, Yun Ju, Cruchaga, Carlos

“…Background Leucine‐rich repeat kinase 2 (LRRK2) common gene variants (tagged by rs76904798) are associated with Parkinson’s disease (PD) risk. In a previous…”
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Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome by Gorijala, Priyanka, Aslam, M. Muaaz, Dang, Lam‐Ha T., Xicota, L., Fernandez, Maria V., Sung, Yun Ju, Fan, Kang‐Hsien, Feingold, Eleanor, Surace, Ezequiel I., Chhatwal, Jasmeer P, Hom, Christy L., Hartley, Sigan L., Hassenstab, Jason, Perrin, Richard J., Mapstone, Mark, Zaman, Shahid H, Ances, Beau M, Kamboh, M. Ilyas, Lee, Joseph H, Cruchaga, Carlos

“…INTRODUCTION This study aimed to investigate the influence of the overall Alzheimer's disease (AD) genetic architecture on Down syndrome (DS) status, cognitive…”
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Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning by Neumann, Alexander, Ohlei, Olena, Küçükali, Fahri, Bos, Isabelle J, Timsina, Jigyasha, Vos, Stephanie, Prokopenko, Dmitry, Tijms, Betty M, Andreasson, Ulf, Blennow, Kaj, Vandenberghe, Rik, Scheltens, Philip, Teunissen, Charlotte E, Engelborghs, Sebastiaan, Frisoni, Giovanni B, Blin, Oliver, Richardson, Jill C, Bordet, Régis, Lleó, Alberto, Alcolea, Daniel, Popp, Julius, Marsh, Thomas W, Gorijala, Priyanka, Clark, Christopher, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Dobson, Richard J B, Legido-Quigley, Cristina, Van Broeckhoven, Christine, Tanzi, Rudolph E, Ten Kate, Mara, Lill, Christina M, Barkhof, Frederik, Cruchaga, Carlos, Lovestone, Simon, Streffer, Johannes, Zetterberg, Henrik, Visser, Pieter Jelle, Sleegers, Kristel, Bertram, Lars

“…Genome-wide association studies (GWAS) of Alzheimer's disease (AD) have identified several risk loci, but many remain unknown. Cerebrospinal fluid (CSF)…”
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