Search Results - "Gori, Sadakatali"

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  1. 1

    Clinical development of metabolic inhibitors for oncology by Lemberg, Kathryn M, Gori, Sadakatali S, Tsukamoto, Takashi, Rais, Rana, Slusher, Barbara S

    Published in The Journal of clinical investigation (01-01-2022)
    “…Metabolic inhibitors have been used in oncology for decades, dating back to antimetabolites developed in the 1940s. In the past 25 years, there has been…”
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    Journal Article
  2. 2

    Lipid Peroxidation Produces a Diverse Mixture of Saturated and Unsaturated Aldehydes in Exhaled Breath That Can Serve as Biomarkers of Lung Cancer—A Review by Sutaria, Saurin R., Gori, Sadakatali S., Morris, James D., Xie, Zhenzhen, Fu, Xiao-An, Nantz, Michael H.

    Published in Metabolites (18-06-2022)
    “…The peroxidation of unsaturated fatty acids is a widely recognized metabolic process that creates a complex mixture of volatile organic compounds including…”
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  3. 3

    A Chemoselective, One-Pot Transformation of Aldehydes to Nitriles by Laulhé, Sébastien, Gori, Sadakatali S, Nantz, Michael H

    Published in Journal of organic chemistry (19-10-2012)
    “…This paper describes a procedure for direct conversion of aldehydes to nitriles using O-(diphenylphosphinyl)hydroxylamine (DPPH). Aldehydes are smoothly…”
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  4. 4

    Intramolecular Hydrogen Bonding Based CEST MRI Contrast Agents As an Emerging Design Strategy: A Mini-Review by Mohanta, Zinia, Gori, Sadakatali, McMahon, Michael T.

    Published in ACS omega (02-07-2024)
    “…Intramolecular hydrogen bonding-based chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) contrast agents represent an innovative…”
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    Journal Article
  5. 5

    Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement by Alt, Jesse, Gori, Sadakatali S, Lemberg, Kathryn M, Pal, Arindom, Veeravalli, Vijayabhaskar, Wu, Ying, Aguilar, Joanna M H, Dash, Ranjeet P, Tenora, Lukáš, Majer, Pavel, Sun, Qi, Slusher, Barbara S, Rais, Rana

    Published in Current drug metabolism (01-01-2021)
    “…Metabolomic analyses from our group and others have shown that tumors treated with glutamine antagonists (GA) exhibit robust accumulation of formylglycinamide…”
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    Journal Article
  6. 6

    D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II by Gori, Sadakatali S, Thomas, Ajit G, Pal, Arindom, Wiseman, Robyn, Ferraris, Dana V, Gao, Run-Duo, Wu, Ying, Alt, Jesse, Tsukamoto, Takashi, Slusher, Barbara S, Rais, Rana

    Published in Pharmaceutics (23-09-2022)
    “…Glutamate carboxypeptidase-II (GCPII) is a zinc-dependent metalloenzyme implicated in numerous neurological disorders. The pharmacophoric requirements of…”
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  8. 8

    Profiling thiol metabolites and quantification of cellular glutathione using FT-ICR-MS spectrometry by Gori, Sadakatali S., Lorkiewicz, Pawel, Ehringer, Daniel S., Belshoff, Alex C., Higashi, Richard M., Fan, Teresa W.-M., Nantz, Michael H.

    Published in Analytical and bioanalytical chemistry (01-07-2014)
    “…We describe preparation and use of the quaternary ammonium-based α-iodoacetamide QDE and its isotopologue *QDE as reagents for chemoselective derivatization of…”
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    Journal Article
  9. 9

    Isolation of C5-Sugars from the Hemicellulose-Rich Hydrolyzate of Distillers Dried Grains by Gori, Sadakatali S, Raju, Mandapati V. Ramakrishnam, Fonseca, Dania A, Satyavolu, Jagannadh, Burns, Christopher T, Nantz, Michael H

    Published in ACS sustainable chemistry & engineering (05-10-2015)
    “…A three-stage process for isolation and separation of C5-sugars in dry form from the hydrolyzate of distillers dried grains (DDG) is described. The salient…”
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    Journal Article
  10. 10

    Discovery of Orally Bioavailable and Brain-Penetrable Prodrugs of the Potent nSMase2 Inhibitor DPTIP by Pal, Arindom, Gori, Sadakatali, Yoo, Seung-wan, Thomas, Ajit G., Wu, Ying, Friedman, Jacob, Tenora, Lukáš, Bhasin, Harshit, Alt, Jesse, Haughey, Norman, Slusher, Barbara S., Rais, Rana

    Published in Journal of medicinal chemistry (25-08-2022)
    “…Extracellular vesicles (EVs) can carry pathological cargo and play an active role in disease progression. Neutral sphingomyelinase-2 (nSMase2) is a critical…”
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    Journal Article
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