Search Results - "Gori, Sadakatali"
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Clinical development of metabolic inhibitors for oncology
Published in The Journal of clinical investigation (01-01-2022)“…Metabolic inhibitors have been used in oncology for decades, dating back to antimetabolites developed in the 1940s. In the past 25 years, there has been…”
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Lipid Peroxidation Produces a Diverse Mixture of Saturated and Unsaturated Aldehydes in Exhaled Breath That Can Serve as Biomarkers of Lung Cancer—A Review
Published in Metabolites (18-06-2022)“…The peroxidation of unsaturated fatty acids is a widely recognized metabolic process that creates a complex mixture of volatile organic compounds including…”
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A Chemoselective, One-Pot Transformation of Aldehydes to Nitriles
Published in Journal of organic chemistry (19-10-2012)“…This paper describes a procedure for direct conversion of aldehydes to nitriles using O-(diphenylphosphinyl)hydroxylamine (DPPH). Aldehydes are smoothly…”
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Intramolecular Hydrogen Bonding Based CEST MRI Contrast Agents As an Emerging Design Strategy: A Mini-Review
Published in ACS omega (02-07-2024)“…Intramolecular hydrogen bonding-based chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) contrast agents represent an innovative…”
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Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement
Published in Current drug metabolism (01-01-2021)“…Metabolomic analyses from our group and others have shown that tumors treated with glutamine antagonists (GA) exhibit robust accumulation of formylglycinamide…”
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D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II
Published in Pharmaceutics (23-09-2022)“…Glutamate carboxypeptidase-II (GCPII) is a zinc-dependent metalloenzyme implicated in numerous neurological disorders. The pharmacophoric requirements of…”
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Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma‑1 Receptor Ligand
Published in ACS chemical neuroscience (01-03-2023)“…Reduced haloperidol (1) was previously reported to act as a potent sigma-1 receptor (S1R) ligand with substantially lower affinity to the dopamine D2 receptor…”
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Profiling thiol metabolites and quantification of cellular glutathione using FT-ICR-MS spectrometry
Published in Analytical and bioanalytical chemistry (01-07-2014)“…We describe preparation and use of the quaternary ammonium-based α-iodoacetamide QDE and its isotopologue *QDE as reagents for chemoselective derivatization of…”
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Isolation of C5-Sugars from the Hemicellulose-Rich Hydrolyzate of Distillers Dried Grains
Published in ACS sustainable chemistry & engineering (05-10-2015)“…A three-stage process for isolation and separation of C5-sugars in dry form from the hydrolyzate of distillers dried grains (DDG) is described. The salient…”
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Discovery of Orally Bioavailable and Brain-Penetrable Prodrugs of the Potent nSMase2 Inhibitor DPTIP
Published in Journal of medicinal chemistry (25-08-2022)“…Extracellular vesicles (EVs) can carry pathological cargo and play an active role in disease progression. Neutral sphingomyelinase-2 (nSMase2) is a critical…”
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Discovery of tert -Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery
Published in Journal of medicinal chemistry (23-11-2023)“…The glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON) exhibits remarkable anticancer efficacy; however, its therapeutic potential is hindered by its…”
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Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata
Published in PNAS nexus (01-01-2023)“…Alopecia areata is a chronic hair loss disorder that involves autoimmune disruption of hair follicles by CD8 T cells. Most patients present with patchy hair…”
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