Search Results - "Gorgun, Cem Z"

Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes by Özcan, Umut, Yilmaz, Erkan, Özcan, Lale, Furuhashi, Masato, Vaillancourt, Eric, Smith, Ross O, Görgün, Cem Z, Hotamisligil, Gökhan S

“…Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type 2 diabetes. Here, we provide evidence that this mechanistic link…”
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Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2 by Makowski, Liza, Hotamisligil, Gökhan S, Tuncman, Gürol, Görgün, Cem Z, Fazio, Sergio, Parker, Rex A, Kono, Keita, Robl, Jeffrey A, Atsumi, Genichi, Sulsky, Richard, Babaev, Vladimir R, Furuhashi, Masato, Linton, MacRae F, Vaillancourt, Eric

“…Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Studies in…”
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Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders by Fukuda, Daiju, Aikawa, Elena, Swirski, Filip K, Novobrantseva, Tatiana I, Kotelianski, Victor, Gorgun, Cem Z, Chudnovskiy, Aleksey, Yamazaki, Hiroyuki, Croce, Kevin, Weissleder, Ralph, Aster, Jon C, Hotamisligil, Gökhan S, Yagita, Hideo, Aikawa, Masanori

“…Atherosclerosis and insulin resistance are major components of the cardiometabolic syndrome, a global health threat associated with a systemic inflammatory…”
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A central role for JNK in obesity and insulin resistance by Hotamisligil, Gökhan S, Hirosumi, Jiro, Tuncman, Gürol, Chang, Lufen, Görgün, Cem Z, Uysal, K. Teoman, Maeda, Kazuhisa, Karin, Michael

“…Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanisms of…”
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Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling by Steinberg, Gregory R., Michell, Belinda J., van Denderen, Bryce J.W., Watt, Matthew J., Carey, Andrew L., Fam, Barbara C., Andrikopoulos, Sofianos, Proietto, Joseph, Görgün, Cem Z., Carling, David, Hotamisligil, Gökhan S., Febbraio, Mark A., Kay, Thomas W., Kemp, Bruce E.

“…Elevated levels of tumor necrosis factor (TNFα) are implicated in the development of insulin resistance, but the mechanisms mediating these chronic effects are…”
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Role of the Fatty Acid Binding Protein mal1 in Obesity and Insulin Resistance by Maeda, Kazuhisa, Uysal, K Teoman, Makowski, Liza, Görgün, Cem Z, Atsumi, Genichi, Parker, Rex A, Brüning, Jens, Hertzel, Ann Vogel, Bernlohr, David A, Hotamisligil, Gökhan S

“…Role of the Fatty Acid Binding Protein mal1 in Obesity and Insulin Resistance Kazuhisa Maeda 1 , K. Teoman Uysal 1 , Liza Makowski 1 , Cem Z. Görgün 1 ,…”
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Coordinated Regulation of Nutrient and Inflammatory Responses by STAMP2 Is Essential for Metabolic Homeostasis by Wellen, Kathryn E., Fucho, Raquel, Gregor, Margaret F., Furuhashi, Masato, Morgan, Carlos, Lindstad, Torstein, Vaillancourt, Eric, Gorgun, Cem Z., Saatcioglu, Fahri, Hotamisligil, Gökhan S.

“…Metabolic and inflammatory pathways crosstalk at many levels, and, while required for homeostasis, interaction between these pathways can also lead to…”
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Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes by Maeda, Kazuhisa, Cao, Haiming, Kono, Keita, Gorgun, Cem Z., Furuhashi, Masato, Uysal, Kadir T., Cao, Qiong, Atsumi, Genichi, Malone, Harry, Krishnan, Bala, Minokoshi, Yasuhiko, Kahn, Barbara B., Parker, Rex A., Hotamisligil, Gökhan S.

“…Fatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role and mechanisms of action are not well understood. Here, we…”
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Regulation of Metabolic Responses by Adipocyte/ Macrophage Fatty Acid–Binding Proteins in Leptin-Deficient Mice by Cao, Haiming, Maeda, Kazuhisa, Gorgun, Cem Z, Kim, Hyo-Jeong, Park, So-Young, Shulman, Gerald I, Kim, Jason K, Hotamisligil, Gökhan S

“…Regulation of Metabolic Responses by Adipocyte/ Macrophage Fatty Acid–Binding Proteins in Leptin-Deficient Mice Haiming Cao 1 , Kazuhisa Maeda 1 , Cem Z…”
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Deficiency of Fatty Acid-Binding Proteins in Mice Confers Protection from Development of Experimental Autoimmune Encephalomyelitis by Reynolds, Joseph M, Liu, Qiaohong, Brittingham, Katherine C, Liu, Yawei, Gruenthal, Michael, Gorgun, Cem Z, Hotamisligil, Gokhan S, Stout, Robert D, Suttles, Jill

“…Fatty acid-binding proteins (FABPs) act as intracellular receptors for a variety of hydrophobic compounds, enabling their diffusion within the cytoplasmic…”
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Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis by Nakamura, Takahisa, Furuhashi, Masato, Li, Ping, Cao, Haiming, Tuncman, Gurol, Sonenberg, Nahum, Gorgun, Cem Z., Hotamisligil, Gökhan S.

“…As chronic inflammation is a hallmark of obesity, pathways that integrate nutrient- and pathogen sensing pathways are of great interest in understanding the…”
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Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice by Furuhashi, Masato, Fucho, Raquel, Görgün, Cem Z, Tuncman, Gürol, Cao, Haiming, Hotamisligil, Gökhan S

“…Adipose tissue inflammation is a characteristic of obesity. However, the mechanisms that regulate this inflammatory response and link adipose inflammation to…”
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Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice by Zhang, Jie, Doria, Alessandro, Libby, Peter, Hotamisligil, Gökhan S, Sun, Jiusong, Blumberg, Richard S, Glickman, Jonathan N, Wolters, Paul J, Divoux, Adeline, Sukhova, Galina K, Kahn, Barbara B, Gorgun, Cem Z, Du, Juan, Shi, Guo-Ping, Clément, Karine, Liu, Jian

“…Although mast cell functions have classically been related to allergic responses, recent studies indicate that these cells contribute to other common diseases…”
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Neuronal PTP1B regulates body weight, adiposity and leptin action by Bence, Kendra K, Neel, Benjamin G, Kahn, Barbara B, Delibegovic, Mirela, Xue, Bingzhong, Gorgun, Cem Z, Hotamisligil, Gokhan S

“…Obesity is a major health problem and a risk factor for type 2 diabetes. Leptin, an adipocyte-secreted hormone, acts on the hypothalamus to inhibit food intake…”
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The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation by Shum, Bennett O V, Mackay, Charles R, Gorgun, Cem Z, Frost, Melinda J, Kumar, Rakesh K, Hotamisligil, Gökhan S, Rolph, Michael S

“…The adipocyte fatty acid-binding protein aP2 regulates systemic glucose and lipid metabolism. We report that aP2, in addition to being abundantly expressed by…”
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Regulation of Dendritic Cell Function and T Cell Priming by the Fatty Acid-Binding Protein aP2 by Rolph, Michael S, Young, Timothy R, Shum, Bennett O. V, Gorgun, Cem Z, Schmitz-Peiffer, Carsten, Ramshaw, Ian A, Hotamisligil, Gokhan S, Mackay, Charles R

“…The fatty acid-binding protein (FABP) family consists of a number of conserved cytoplasmic proteins with roles in intracellular lipid transport, storage, and…”
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Author Correction: A central role for JNK in obesity and insulin resistance by Hirosumi, Jiro, Tuncman, Gürol, Chang, Lufen, Görgün, Cem Z., Uysal, K. Teoman, Maeda, Kazuhisa, Karin, Michael, Hotamisligil, Gökhan S.

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Macrophage Mal1 Deficiency Suppresses Atherosclerosis in Low-Density Lipoprotein Receptor–Null Mice by Activating Peroxisome Proliferator-Activated Receptor-γ–Regulated Genes by Babaev, Vladimir R, Runner, Robert P, Fan, Daping, Ding, Lei, Zhang, Youmin, Tao, Huan, Erbay, Ebru, Görgün, Cem Z, Fazio, Sergio, Hotamisligil, Gökhan S, Linton, MacRae F

“…OBJECTIVE—The adipocyte/macrophage fatty acid-binding proteins aP2 (FABP4) and Mal1 (FABP5) are intracellular lipid chaperones that modulate systemic glucose…”
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Neuronal PTP1B regulates body weight, adiposity and leptin action

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Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders by Fukuda, Daiju, Aikawa, Elena, Swirski, Filip K., Novobrantseva, Tatiana I., Kotelianski, Victor, Gorgun, Cem Z., Chudnovskiy, Aleksey, Yamazaki, Hiroyuki, Croce, Kevin, Weissleder, Ralph, Aster, Jon C., Hotamisligil, Gökhan S., Yagita, Hideo, Aikawa, Masanori

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