The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

We report the identification of ligands for Tyro 3 (alternatively called Sky, rse, brt, or tif) and Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosine kinases. These ligands correspond to protein S, a protease regulator that is a potent anticoagulant, an...

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Bibliographic Details
Published in:	Cell Vol. 80; no. 4; pp. 661 - 670
Main Authors:	Stitt, Trevor N, Conn, Greg, Goret, Martin, Lai, Cary, Bruno, Joanne, Radzlejewski, Czeslaw, Mattsson, Karen, Fisher, John, Gies, David R, Jones, Pamela F, Masiakowski, Piotr, Ryan, Terence E, Tobkes, Nancy J, Chen, D.H, DiStefano, Peter S, Long, George L, Basilico, Claudio, Goldfarb, Mitchell P, Lemke, Greg, Glass, David J, Yancopoulos, George D
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 24-02-1995
Subjects:	3T3 Cells Amino Acid Sequence Animals Astrocytes - metabolism Axl Receptor Tyrosine Kinase Blotting, Northern Cell Division Chromatography, Affinity Gene Expression Regulation Intercellular Signaling Peptides and Proteins Ligands Mice Models, Biological Molecular Sequence Data Oncogene Proteins - genetics Oncogene Proteins - metabolism Phosphorylation Protein Binding Protein S - genetics Protein S - metabolism Proteins - genetics Proteins - metabolism Proto-Oncogene Proteins Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Recombinant Fusion Proteins - metabolism RNA, Messenger - analysis Schwann Cells - metabolism
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Summary:	We report the identification of ligands for Tyro 3 (alternatively called Sky, rse, brt, or tif) and Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosine kinases. These ligands correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related to protein S but lacking any known function. Our results are reminiscent of recent findings that the procoagulant thrombin, a protease that drives clot formation by cleaving fibrinogen to form fibrin, also binds and activates intracellular signaling via a G protein-coupled cell surface receptor. Proteases and protease regulators that also activate specific cell surface receptors may serve to integrate coagulation with associated cellular responses required for tissue repair and growth, as well as to coordinate protease cascades and associated cellular responses in other systems, such as those involved in growth and remodeling of the nervous system.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0092-8674 1097-4172
DOI:	10.1016/0092-8674(95)90520-0