Search Results - "Gores, G. J."

Apoptosis: a mechanism of acute and chronic liver injury by Guicciardi, M E, Gores, G J

“…19 Apoptosis of liver cells has now been linked to liver fibrosis in several studies. [...]the physiological concept that liver cell apoptosis is "innocuous"…”
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mir-29 regulates Mcl-1 protein expression and apoptosis by MOTT, J. L, KOBAYASHI, S, BRONK, S. F, GORES, G. J

“…Cellular expression of Mcl-1, an anti-apoptotic Bcl-2 family member, is tightly regulated. Recently, Bcl-2 expression was shown to be regulated by microRNAs,…”
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Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis by Schoenleber, S J, Kurtz, D M, Talwalkar, J A, Roberts, L R, Gores, G J

“…Hepatocellular carcinoma (HCC) is a highly vascular tumour that expresses vascular endothelial growth factor (VEGF). Various studies have evaluated the…”
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Proteasome Inhibition Causes Apoptosis of Normal Human Plasma Cells Preventing Alloantibody Production by Perry, D. K., Burns, J. M., Pollinger, H. S., Amiot, B. P., Gloor, J. M., Gores, G. J., Stegall, M. D.

“…Antibody production by normal plasma cells (PCs) against human leukocyte antigens (HLA) can be a major barrier to successful transplantation. We tested four…”
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Review article: the modern diagnosis and therapy of cholangiocarcinoma by MALHI, H., GORES, G. J.

“…Summary Cholangiocarcinomas are epithelial neoplasms that originate from cholangiocytes and can occur at any level of the biliary tree. They are broadly…”
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Clinical Trial of the Pan‐Caspase Inhibitor, IDN‐6556, in Human Liver Preservation Injury by Baskin‐Bey, E. S., Washburn, K., Feng, S., Oltersdorf, T., Shapiro, D., Huyghe, MiRa, Burgart, L., Garrity‐Park, M., Van Vilsteren, F. G. I., Oliver, L. K., Rosen, C. B., Gores, G. J.

“…Cold ischemia/warm reperfusion (CI/WR) injury remains a problem in liver transplantation. The aim of the current study was to assess the utility of the…”
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GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis by Kurita, S, Mott, J L, Almada, L L, Bronk, S F, Werneburg, N W, Sun, S-Y, Roberts, L R, Fernandez-Zapico, M E, Gores, G J

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis through its cognate receptors death receptor 4 (DR4) and death receptor 5…”
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Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas by Miyoshi, Hideyuki, Rust, Christian, Roberts, Patricia J., Burgart, Lawrence J., Gores, Gregory J.

“…Background & Aims: Cholestatic liver injury results from the intrahepatic accumulation of toxic bile salts. Toxic bile salt–induced hepatocyte apoptosis in…”
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Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury by Baskin-Bey, E S, Canbay, A, Bronk, S F, Werneburg, N, Guicciardi, M E, Nyberg, S L, Gores, G J

“…Hepatic steatosis predisposes the liver to cold ischemia-warm reperfusion (CI/WR) injury by unclear mechanisms. Because hepatic steatosis has recently been…”
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Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism by JAISWAL, M, LARUSSO, N. F, BURGART, L. J, GORES, G. J

“…Chronic infection and inflammation are risk factors for the development of cholangiocarcinoma, a highly malignant, generally fatal adenocarcinoma originating…”
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Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis by Jaiswal, M, LaRusso, N F, Gores, G J

“…Chronic inflammation of gastrointestinal tissues is a well-recognized risk factor for the development of epithelial cell-derived malignancies. Although the…”
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Apoptosis and liver disease by Rust, C, Gores, G J

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Ursodeoxycholic acid or clofibrate in the treatment of non‐alcohol‐induced steatohepatitis: A pilot study by Laurin, J, Lindor, K D, Crippin, J S, Gossard, A, Gores, G J, Ludwig, J, Rakela, J, McGill, D B

“…Non‐alcohol‐induced steatohepatitis (NASH) is characterized by elevated serum aminotransferase activities with hepatic steatosis, inflammation, and…”
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Cell death by apoptosis: Basic concepts and disease relevance for the gastroenterologist by Que, FG, Gores, GJ

“…We have reviewed in a conceptual manner with appropriate scientific detail the role apoptosis plays in diseases of the gastrointestinal tract. This information…”
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Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications by Guicciardi, M E, Miyoshi, H, Bronk, S F, Gores, G J

“…Tumor necrosis factor-alpha (TNF-alpha) contributes to liver injury by inducing hepatocyte apoptosis. Recent evidence suggests that cathepsin B (cat B)…”
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Pathogenesis, diagnosis, and treatment of alcoholic liver disease by Menon, K V, Gores, G J, Shah, V H

“…Alcohol-related liver disease is a major cause of morbidity and mortality in the United States. Alcoholic liver disease encompasses a clinicohistological…”
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Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes by Roberts, LR, Kurosawa, H, Bronk, SF, Fesmier, PJ, Agellon, LB, Leung, WY, Mao, F, Gores, GJ

“…BACKGROUND & AIMS: Bile salt-induced apoptosis is mediated by a trypsin- like nuclear protease. The aims of this study were to identify this protease and to…”
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The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis by Patel, Anand H, Harnois, Denise M, Klee, George G, LaRusso, Nicholas F, Gores, Gregory J

“…The diagnosis of cholangiocarcinoma is often difficult, making management approaches problematic. A reliable serum tumor marker for cholangiocarcinoma would be…”
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Death by association: BH3 domain-only proteins and liver injury by Baskin-Bey, E S, Gores, G J

“…Apoptosis, a prominent form of cell death, is a prime feature of many acute and chronic liver diseases. Apoptosis requires mitochondrial dysfunction, which is…”
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Inhibition of interleukin 6–mediated mitogen‐activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line by Park, Joongwon, Tadlock, Laura, Gores, Gregory J., Patel, Tushar

“…Biliary tract malignancies represent challenges because of the lack of effective therapy and poor prognosis, in part because of the paucity of information…”
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