Search Results - "Gorelik, Julia"

Heart and bile acids – Clinical consequences of altered bile acid metabolism by Vasavan, Tharni, Ferraro, Elisa, Ibrahim, Effendi, Dixon, Peter, Gorelik, Julia, Williamson, Catherine

“…Cardiac dysfunction has an increased prevalence in diseases complicated by liver cirrhosis such as primary biliary cholangitis and primary sclerosing…”
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FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility by Surdo, Nicoletta C., Berrera, Marco, Koschinski, Andreas, Brescia, Marcella, Machado, Matias R., Carr, Carolyn, Wright, Peter, Gorelik, Julia, Morotti, Stefano, Grandi, Eleonora, Bers, Donald M., Pantano, Sergio, Zaccolo, Manuela

“…Compartmentalized cAMP/PKA signalling is now recognized as important for physiology and pathophysiology, yet a detailed understanding of the properties,…”
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Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP by Subramanian, Hariharan, Froese, Alexander, Jönsson, Peter, Schmidt, Hannes, Gorelik, Julia, Nikolaev, Viacheslav O.

“…Natriuretic peptides (NPs) are important hormones that regulate multiple cellular functions including cardiovascular physiology. In the heart, two natriuretic…”
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Microtubules regulate cardiomyocyte transversal Young’s modulus by Swiatlowska, Pamela, Sanchez-Alonso, Jose L., Wright, Peter T., Novak, Pavel, Gorelik, Julia

“…The field of cardiomyocyte mechanobiology is gaining significant attention, due to accumulating evidence concerning the significant role of cellular mechanical…”
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Bile acids and their respective conjugates elicit different responses in neonatal cardiomyocytes: role of Gi protein, muscarinic receptors and TGR5 by Ibrahim, Effendi, Diakonov, Ivan, Arunthavarajah, Dulasi, Swift, Teresa, Goodwin, Mary, McIlvride, Saraid, Nikolova, Vanya, Williamson, Catherine, Gorelik, Julia

“…Bile acids are recognised as bioactive signalling molecules. While they are known to influence arrhythmia susceptibility in cholestasis, there is limited…”
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Topographical and electrochemical nanoscale imaging of living cells using voltage-switching mode scanning electrochemical microscopy by Takahashi, Yasufumi, Shevchuk, Andrew I., Novak, Pavel, Babakinejad, Babak, Macpherson, Julie, Unwin, Patrick R., Shiku, Hitoshi, Gorelik, Julia, Klenerman, David, Korchev, Yuri E., Matsue, Tomokazu

“…We describe voltage-switching mode scanning electrochemical microscopy (VSM-SECM), in which a single SECM tip electrode was used to acquire high-quality…”
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Super-resolution Scanning Patch Clamp Reveals Clustering of Functional Ion Channels in Adult Ventricular Myocyte by Bhargava, Anamika, Lin, Xianming, Novak, Pavel, Mehta, Kinneri, Korchev, Yuri, Delmar, Mario, Gorelik, Julia

“…RATIONALE:Compartmentation of ion channels on the cardiomyocyte surface is important for electric propagation and electromechanical coupling. The specialized…”
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Voltage-Gated T-Type Calcium Channel Modulation by Kinases and Phosphatases: The Old Ones, the New Ones, and the Missing Ones by Sharma, Ankush, Rahman, Ghazala, Gorelik, Julia, Bhargava, Anamika

“…Calcium (Ca ) can regulate a wide variety of cellular fates, such as proliferation, apoptosis, and autophagy. More importantly, changes in the intracellular Ca…”
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Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure by Sanchez-Alonso, Jose L, Bhargava, Anamika, O’Hara, Thomas, Glukhov, Alexey V, Schobesberger, Sophie, Bhogal, Navneet, Sikkel, Markus B, Mansfield, Catherine, Korchev, Yuri E, Lyon, Alexander R, Punjabi, Prakash P, Nikolaev, Viacheslav O, Trayanova, Natalia A, Gorelik, Julia

“…RATIONALE:Disruption in subcellular targeting of Ca signaling complexes secondary to changes in cardiac myocyte structure may contribute to the pathophysiology…”
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Loss of T-tubules and Other Changes to Surface Topography in Ventricular Myocytes from Failing Human and Rat Heart by Lyon, Alexander R., MacLeod, Ken T., Zhang, Yanjun, Garcia, Edwin, Kanda, Gaelle Kikonda, Lab, Max J., Korchev, Yuri E., Harding, Sian E., Gorelik, Julia, Marks, Andrew R.

“…T-tubular invaginations of the sarcolemma of ventricular cardiomyocytes contain junctional structures functionally coupling L-type calcium channels to the…”
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Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell Analysis by Zhang, Yanjun, Clausmeyer, Jan, Babakinejad, Babak, López Córdoba, Ainara, Ali, Tayyibah, Shevchuk, Andrew, Takahashi, Yasufumi, Novak, Pavel, Edwards, Christopher, Lab, Max, Gopal, Sahana, Chiappini, Ciro, Anand, Uma, Magnani, Luca, Coombes, R. Charles, Gorelik, Julia, Matsue, Tomokazu, Schuhmann, Wolfgang, Klenerman, David, Sviderskaya, Elena V, Korchev, Yuri

“…Nanometric field-effect-transistor (FET) sensors are made on the tip of spear-shaped dual carbon nanoelectrodes derived from carbon deposition inside…”
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Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc by Leo-Macias, Alejandra, Agullo-Pascual, Esperanza, Sanchez-Alonso, Jose L., Keegan, Sarah, Lin, Xianming, Arcos, Tatiana, Feng-Xia-Liang, Korchev, Yuri E., Gorelik, Julia, Fenyö, David, Rothenberg, Eli, Delmar, Mario

“…Intercellular adhesion and electrical excitability are considered separate cellular properties. Studies of myelinated fibres, however, show that voltage-gated…”
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The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation by Veeraraghavan, Rengasayee, Hoeker, Gregory S, Alvarez-Laviada, Anita, Hoagland, Daniel, Wan, Xiaoping, King, D Ryan, Sanchez-Alonso, Jose, Chen, Chunling, Jourdan, Jane, Isom, Lori L, Deschenes, Isabelle, Smyth, James W, Gorelik, Julia, Poelzing, Steven, Gourdie, Robert G

“…Computational modeling indicates that cardiac conduction may involve ephaptic coupling - intercellular communication involving electrochemical signaling across…”
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Direct Evidence for Microdomain-Specific Localization and Remodeling of Functional L-Type Calcium Channels in Rat and Human Atrial Myocytes by Glukhov, Alexey V, Balycheva, Marina, Sanchez-Alonso, Jose L, Ilkan, Zeki, Alvarez-Laviada, Anita, Bhogal, Navneet, Diakonov, Ivan, Schobesberger, Sophie, Sikkel, Markus B, Bhargava, Anamika, Faggian, Giuseppe, Punjabi, Prakash P, Houser, Steven R, Gorelik, Julia

“…BACKGROUND—Distinct subpopulations of L-type calcium channels (LTCCs) with different functional properties exist in cardiomyocytes. Disruption of cellular…”
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Correlative SICM‐FCM reveals changes in morphology and kinetics of endocytic pits induced by disease‐associated mutations in dynamin by Ali, Tayyibah, Bednarska, Joanna, Vassilopoulos, Stéphane, Tran, Martin, Diakonov, Ivan A., Ziyadeh-Isleem, Azza, Guicheney, Pascale, Gorelik, Julia, Korchev, Yuri E., Reilly, Mary M., Bitoun, Marc, Shevchuk, Andrew

“…ABSTRACT Dynamin 2 (DNM2) is a GTP‐binding protein that controls endocytic vesicle scission and defines a whole class of dynamin‐dependent endocytosis,…”
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Nanoscale Study of Calcium Handling Remodeling in Right Ventricular Cardiomyocytes Following Pulmonary Hypertension by Medvedev, Roman, Sanchez-Alonso, Jose L., Alvarez-Laviada, Anita, Rossi, Stefano, Dries, Eef, Schorn, Tilo, Abdul-Salam, Vahitha B., Trayanova, Natalia, Wojciak-Stothard, Beata, Miragoli, Michele, Faggian, Giuseppe, Gorelik, Julia

“…Pulmonary hypertension is a complex disorder characterized by pulmonary vascular remodeling and right ventricular hypertrophy, leading to right heart failure…”
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Nanoscale-Targeted Patch-Clamp Recordings of Functional Presynaptic Ion Channels by Novak, Pavel, Gorelik, Julia, Vivekananda, Umesh, Shevchuk, Andrew I., Ermolyuk, Yaroslav S., Bailey, Russell J., Bushby, Andrew J., Moss, Guy W.J., Rusakov, Dmitri A., Klenerman, David, Kullmann, Dimitri M., Volynski, Kirill E., Korchev, Yuri E.

“…Direct electrical access to presynaptic ion channels has hitherto been limited to large specialized terminals such as the calyx of Held or hippocampal mossy…”
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Local hyperactivation of L-type Ca2+ channels increases spontaneous Ca2+ release activity and cellular hypertrophy in right ventricular myocytes from heart failure rats by Medvedev, Roman Y., Sanchez-Alonso, Jose L., Mansfield, Catherine A., Judina, Aleksandra, Francis, Alice J., Pagiatakis, Christina, Trayanova, Natalia, Glukhov, Alexey V., Miragoli, Michele, Faggian, Giuseppe, Gorelik, Julia

“…Right ventricle (RV) dysfunction is an independent predictor of patient survival in heart failure (HF). However, the mechanisms of RV progression towards…”
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Prolonged ursodeoxycholic acid administration reduces acute ischaemia-induced arrhythmias in adult rat hearts by Ferraro, Elisa, Pozhidaeva, Lidia, Pitcher, David S., Mansfield, Catherine, Koh, Jia Han Benjamin, Williamson, Catherine, Aslanidi, Oleg, Gorelik, Julia, Ng, Fu Siong

“…Acute myocardial ischaemia and reperfusion (I–R) are major causes of ventricular arrhythmias in patients with a history of coronary artery disease…”
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Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc by Yang, Hua-Qian, Pérez-Hernández, Marta, Sanchez-Alonso, Jose, Shevchuk, Andriy, Gorelik, Julia, Rothenberg, Eli, Delmar, Mario, Coetzee, William A

“…We investigated targeting mechanisms of Na + and K ATP channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data…”
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