Search Results - "Gorelick, N J"

Overview of mutation assays in transgenic mice for routine testing by Gorelick, N J

“…There is scientific and regulatory interest in using mutation assays in transgenic mice in safety assessments for new chemicals and drugs. Currently these…”
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In vivo transgenic mutation assays by Heddle, John A., Dean, Stephen, Nohmi, Takehiko, Boerrigter, Michaël, Casciano, Daniel, Douglas, George R., Glickman, Barry W., Gorelick, Nancy J., Mirsalis, Jon C., Martus, Hans-Jörg, Skopek, Thomas R., Thybaud, Veronique, Tindall, Kenneth R., Yajima, Nobuhiro

“…Transgenic rodent gene mutation models provide quick and statistically reliable assays for mutations in the DNA from any tissue. For regulatory applications,…”
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Statistical design and analysis of mutation studies in transgenic mice by Carr, G J, Gorelick, N J

“…We have been working on identifying sources of variability in data from transgenic mouse mutation assays in order to develop appropriate statistical methods…”
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Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice by WALKER, V. E, GORELICK, N. J, ANDREWS, J. L, CRAFT, T. R, DEBOER, J. G, GLICKMAN, B. W, SKOPEK, T. R

“…The development of mouse models with the endogenous hypoxanthine-guanine phosphoribosyl transferase (hprt) gene and lacI transgene as mutational targets…”
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Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and both the lacI and lacZ gene in transgenic rodents by Cariello, Neal F., Douglas, George R., Dycaico, Mark J., Gorelick, Nancy J., Provost, G. Scott, Soussi, Thierry

“…We have created databases and software applications for the analysis of DNA mutations at the human p53 gene, the human hprt gene and both the rodent transgenic…”
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Mutation assays in male germ cells from transgenic mice: overview of study and conclusions by Ashby, J., Gorelick, N.J., Shelby, M.D.

“…Three confirmed mouse germ cell mutagens, ethyl nitrosourea (ENU), isopropyl methanesulphonate (iPMS) and methyl methanesulphonate (MMS), have been evaluated…”
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Statistical tests of significance in transgenic mutation assays: considerations on the experimental unit by Carr, G J, Gorelick, N J

“…When significant animal-to-animal variability is present in binary response data, the usual statistical tests applied to such data do not always operate…”
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Overview of the workshops on statistical analysis of mutation data from transgenic mice by Gorelick, N J, Thompson, E D

“…Early results from two transgenic mouse mutation assays, Big Blue [Kohler SW et al. (1991): Proc Natl Acad Sci USA 88:7958-7962] and Muta Mouse [Myhr BC…”
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Mutational spectra in transgenic animal research : Data analysis and study design based upon the mutant or mutation frequency by CARR, G. J, GORELICK, N. J

“…Understanding chemically induced changes in mutational spectra can aid in deciphering mechanisms of mutagenesis. In this paper, we propose the use of…”
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In vivo transgenic mutation assays by Thybaud, Véronique, Dean, Stephen, Nohmi, Takehiko, de Boer, Johan, Douglas, George R., Glickman, Barry W., Gorelick, Nancy J., Heddle, John A., Heflich, Robert H., Lambert, Iain, Martus, Hans-Jörg, Mirsalis, Jon C., Suzuki, Takayoshi, Yajima, Nobuhiro

“…Transgenic rodent gene-mutation models provide relatively quick and statistically reliable assays for gene mutations in the DNA from any tissue. This report…”
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A strategy for the application of transgenic rodent mutagenesis assays by GORELICK, N. J, MIRSALIS, J. C

“…The past several years have seen an enormous increase in the development and use of transgenic animal models to measure mutations in specific inserted reporter…”
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EPR and Mössbauer studies of nucleotide-bound nitrogenase iron protein from Azotobacter vinelandii by Lindahl, P A, Gorelick, N J, Münck, E, Orme-Johnson, W H

“…We have recently shown (Lindahl, P. A., Day, E. P., Kent, T. A., Orme-Johnson, W. H., and Münck, E. (1985) J. Biol. Chem. 260, 11160-11173) that the [4Fe-4S]1+…”
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Sources of variability in data from a lacI transgenic mouse mutation assay by Piegorsch, W W, Lockhart, A M, Margolin, B H, Tindall, K R, Gorelick, N J, Short, J M, Carr, G J, Thompson, E D, Shelby, M D

“…Experimental features of a transgenic mouse mutation assay based on a lacI target transgene from Escherichia coli are considered in detail. Sources of…”
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The genetic analysis of lacI mutations in sectored plaques from Big Blue® transgenic mice by STUART, G. R, GORELICK, N. J, ANDREWS, J. L, DE BOER, J. G, GLICKMAN, B. W

“…The Big Blue lacI transgenic rodent assay, which uses the lambda LIZ/lacI gene as the target for mutation, provides a convenient short-term assay for the study…”
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Formation of DNA and hemoglobin adducts of fluoranthene after single and multiple exposures by Gorelick, N J, Hutchins, D A, Tannenbaum, S R, Wogan, G N

“…The dose-dependence of hemoglobin binding as well as distribution of fluoranthene and fluoranthene-DNA adducts in various tissues was characterized in male…”
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Genotoxicity of trans-anethole in vitro by Gorelick, N J

“…Trans-anethole genotoxicity has been evaluated previously both in vitro and in vivo. To ascertain the reproducibility and relevance of previously conducted…”
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Chemical and Biochemical Dosimetry of Exposure to Genotoxic Chemicals by Wogan, Gerald N., Gorelick, Nancy J.

“…Epidemiologic studies designed to evaluate the health significance of environmental chemicals are compromised by the lack of quantitative exposure data for…”
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Validation issues for the use of transgenic mouse mutation assays in risk assessment by Gorelick, N J

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Databases and software for the analysis of mutations in the human p53 gene, human hprt gene and both the lacI and lacZ gene in transgenic rodents by Cariello, Neal F., Douglas, George R., Gorelick, Nancy J., Hart, Daniel W., Wilson, John D., Soussi, Thierry

“…We have created databases and software applications for the analysis of DNA mutations at the human p53 gene, the human hprt gene and both the rodent transgenic…”
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Mutational spectra in the lacl gene in skin from 7,12-dimethylbenz[a]anthracene-treated and untreated transgenic mice by Gorelick, N J, Andrews, J L, Gu, M, Glickman, B W

“…Transgenic mice carrying the bacterial lacl gene in a lambda shuttle vector were used to isolate and characterize background and 7,12-dimethylbenz[a]anthracene…”
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