Search Results - "Gore, Suraj T."

Design, synthesis, and biological evaluation of phenyl thiazole-based AR-V7 degraders by Bhumireddy, Archana, Bandaru, N.V.M. Rao, Raghurami Reddy, B., Gore, Suraj T., Mukherjee, Subhendu, Balasubramanian, Wesley Roy, Sumanth Kumar, V., Alapati, Krishna Satya, Venkata Gowri Chandra Sekhar, Kondapalli, Nellore, Kavitha, Abbineni, Chandrasekhar, Samajdar, Susanta

“…[Display omitted] Multiple Splice variants of AR have been reported in the past few years. These splice variants are upregulated in most cases of CRPC…”
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Plasmodium chitinases: revisiting a target of transmission‐blockade against malaria by Viswanath, Vysakh K., Gore, Suraj T., Valiyaparambil, Ashwathi, Mukherjee, Subhendhu, Lakshminarasimhan, Anirudha

“…Malaria is a life‐threatening disease caused by one of the five species of Plasmodium, among which Plasmodium falciparum cause the deadliest form of the…”
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Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies by Gummadi, Venkateshwar Rao, Boruah, Anima, Ainan, Bharathi Raja, Vare, Brahma Reddy, Manda, Srinivas, Gondle, Hari Prakash, Kumar, Shiva Nagendra, Mukherjee, Subhendu, Gore, Suraj T, Krishnamurthy, Narasimha Rao, Marappan, Sivapriya, Nayak, Shilpa S, Nellore, Kavitha, Balasubramanian, Wesley Roy, Bhumireddy, Archana, Giri, Sanjeev, Gopinath, Sreevalsam, Samiulla, Dodheri S, Daginakatte, Girish, Basavaraju, Aravind, Chelur, Shekar, Eswarappa, Rajesh, Belliappa, Charamanna, Subramanya, Hosahalli S, Booher, Robert N, Ramachandra, Murali, Samajdar, Susanta

“…Small molecule potent IRAK4 inhibitors from a novel bicyclic heterocycle class were designed and synthesized based on hits identified from Aurigene’s compound…”
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Design, Synthesis and Pharmacological Screening of Novel Antihypertensive Agents Using Hybrid Approach by Bhandari, Shashikant V., Bothara, Kailash G., Patil, Ajit A., Chitre, Trupti S., Sarkate, Aniket P., Gore, Suraj T., Dangre, Sudarshan C., Khachane, Chetan V.

“…Eight derivatives of general formula 2-(2-(4-(3-((5-substituted…”
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Design, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs by Bhandari, Shashikant V., Dangre, Sudarshan C., Bothara, Kailash G., Patil, Ajit A., Sarkate, Aniket P., Lokwani, Deepak K., Gore, Suraj T., Deshmane, Bhavana J., Raparti, Vyankatesh T., Khachane, Chetan V.

“…Various substituted 1,5-diarylpyrazol-3-one derivatives were synthesized and screened for analgesic, anti-inflammatory activities, ulcerogenic potential and…”
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Abstract 1144: Orally bioavailable SMARCA2 degraders with exceptional selectivity and potency by Abbineni, Chandrasekhar, Satyam, Leena Khare, Kuila, Bilash, Ettam, Ashok, Rawoof, Khaji Abdul, MR, Sreevidya, Dukare, Sandeep Vitthal, Gore, Suraj T., Nankar, Rakesh P., Ahuja, Vijay Kamal, KB, Charamanna, Goyal, Megha, Aithal, Kiran, DS, Samiulla, Mukherjee, Subhendu, Antony, Thomas, Giri, Sanjeev, Chelur, Shekar, Nellore, Kavitha, Daginakatte, Girish, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Background: SMARCA2 (BRM) and SMARCA4 (BRG1) are two mutually exclusive DNA-dependent ATPases of the SWI/SNF complex, which function in mobilizing…”
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Abstract 1143: Evaluation of AU-18069, a novel small molecule CBP/p300 bromodomain inhibitor for the treatment of cancers by Abbineni, Chandrasekhar, Thiyagarajan, Saravanan, Senaiar, Ramesh S, Mukherjee, Subhendu, Jaleel, Mahaboobi, Marappan, Sivapriya, N R, Raghavendra, Renukappa, Girish Aggunda, B, Aravind A, R, Naveen Kumar, Reddy, Venkata Siva, Babu, Asha, Srinivas, Akhila, Yadlapalli, Prasad, Gore, Suraj T, Hemasankar, Pathange, Dey, Mamon, S, Samiulla D, Naik, Chandranath D, Antony, Thomas, Nellore, Kavitha, Chelur, Shekar, Daginakatte, Girish, Myllymäki, Mikko, Wohlfahrt, Gerd, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Background: E1A binding protein (p300) and its paralog CREB binding protein (CBP or CREBBP) are ubiquitously expressed acetyl transferases (HAT) that…”
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Abstract 3303: Paralogue selective p300 degraders induce synthetic lethality in pre-clinical models of CBP-deficient and p300-dependent malignancies by Thiyagarajan, Saravanan, Abbineni, Chandrasekhar, Chaitanya T, Krishna, Apte, Achala, Iqbal, Iram Khan, Kumar R, Naveen, A B, Aravind, Kumar, Avinash, Babu, Dabbeeru Madhu, Shwetha, Shwetha, Manna, Ankita, Mandal, Monalisha, Panigrahi, Rituparna, Marappan, Sivapriya, Gore, Suraj T, Fairus, Mohamad, Jin, Lim Yang, Mukherjee, Subhendu, Daginakatte, Girish, Chelur, Shekar, Nellore, Kavitha, Ramachandra, Murali, Samajdar, Susanta

“…Abstract EP300 (or p300) acts as histone acetyltransferase (HAT) and transcriptional adapter or co-activator regulating transcription via chromatin remodeling…”
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Abstract 6065: Identification and characterization of paralogue selective CBP degraders for potential use in cancer therapy by Thiyagarajan, Saravanan, Abbineni, Chandrasekhar, Chaitanya T, Krishna, Apte, Achala, Iqbal, Iram Khan, Kumar R, Naveen, A B, Aravind, Kumar, Avinash, A R, Girish, Kamath, Aishwarya B, Mane, Deepak Dattatray, Raj A, Gouri, Reghu, Reshma, Mohapatra, Subhasmita, Marappan, Sivapriya, Gore, Suraj T, Mukherjee, Subhendu, Daginakatte, Girish, Nellore, Kavitha, Chelur, Shekar, Ramachandra, Murali, Samajdar, Susanta

“…Abstract CBP and p300 are closely related epigenetic modulators that participate in chromatin remodeling and transcription and play an oncogenic role in a…”
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Abstract 3729: Discovery of orally bioavailable SMARCA2/4 dual degraders for treatment of acute myeloid leukemia by Abbineni, Chandrasekhar, Khare, Leena, Kuila, Bilash, Khaji, Abdul Rawoof, Mahadeo, Dhaytadak Bhagwan, Dukare, Sandeep Vitthal, Kumar, Bhagya M S, Gore, Suraj T, Ahuja, Vijay Kamal, Dhudashiya, Amit A, N R, Raghavendra, Gowda, Nagesh, K B, Charamanna, Aithal B, Kiran, D S, Samiulla, Mukherjee, Subhendu, Antony, Thomas, Giri, Sanjeev, Chelur, Shekar, Nellore, Kavitha, Daginakatte, Girish, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Background: The BAF (SWI/SNF) chromatin remodeling complex comprises of two mutually exclusive ATPases, SMARCA2 (BRM) and SMARCA4 (BRG1), that affect…”
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Abstract 4114: Evaluation of AU-18069, a novel small molecule CBP/p300 bromodomain inhibitor for the treatment of cancers by Abbineni, Chandrasekhar, Thiyagarajan, Saravanan, A B, Aravind, Dhudashiya, Amit A, Marappan, Sivapriya, Kumar R, Naveen, N R, Raghavendra, Dey, Mamon, Kumar, Avinash, B V, Uma Bharathi, Renukappa, Girish Aggunda, Reddy, N Venkata Siva, Babu, Asha, Shetty, Aakanksha J, A, Amith, Rao K, Narasimha, Gore, Suraj T, Jaleel, Mahaboobi, Senaiar, Ramesh S, Nataraj, Vijaya Shankar, Mukherjee, Subhendu, D S, Samiulla, Antony, Thomas, Daginakatte, Girish, Eswarappa, Rajesh, Nellore, Kavitha, Chelur, Shekar, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Background: E1A binding protein (p300) and its paralog CREB binding protein (CBP or CREBBP) are ubiquitously expressed acetyl transferases (HAT) that…”
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