Search Results - "Gore, Kiran R."

Advances in siRNA therapeutics and synergistic effect on siRNA activity using emerging dual ribose modifications by Gangopadhyay, Sumit, Gore, Kiran R

“…Nucleic acid-based therapeutics that control gene expression have been steadily progressing towards achieving their full clinical potential throughout the last…”
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Folate Receptor-Mediated siRNA Delivery: Recent Developments and Future Directions for RNAi Therapeutics by Gangopadhyay, Sumit, Nikam, Rahul R, Gore, Kiran R

“…RNA interference (RNAi), a gene regulatory process mediated by small interfering RNAs (siRNAs), has made remarkable progress as a potential therapeutic agent…”
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Influence of 2′-Fluoro versus 2′‑O‑Methyl Substituent on the Sugar Puckering of 4′‑C‑Aminomethyluridine by Gore, Kiran R, Harikrishna, S, Pradeepkumar, P. I

“…Herein, we report the synthesis of 4′-C-aminomethyl-2′-deoxy-2′-fluorouridine, a therapeutically appealing RNA modification. Conformational analysis by DFT…”
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Synthesis, Gene Silencing, and Molecular Modeling Studies of 4′-C-Aminomethyl-2′-O-methyl Modified Small Interfering RNAs by Gore, Kiran R, Nawale, Ganesh N, Harikrishna, S, Chittoor, Vinita G, Pandey, Sushil Kumar, Höbartner, Claudia, Patankar, Swati, Pradeepkumar, P. I

“…The linear syntheses of 4′-C-aminomethyl-2′-O-methyl uridine and cytidine nucleoside phosphoramidites were achieved using glucose as the starting material. The…”
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A Multicolor Large Stokes Shift Fluorogen‐Activating RNA Aptamer with Cationic Chromophores by Steinmetzger, Christian, Palanisamy, Navaneethan, Gore, Kiran R., Höbartner, Claudia

“…Large Stokes shift (LSS) fluorescent proteins (FPs) exploit excited state proton transfer pathways to enable fluorescence emission from the phenolate…”
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Investigating the Effect of Chemical Modifications on the Ribose Sugar Conformation, Watson–Crick Base Pairing, and Intrastrand Stacking Interactions: A Theoretical Approach by Das, Gourav, Harikrishna, S., Gore, Kiran R.

“…Over the last few decades, chemically modified sugars have been incorporated into nucleic acid-based therapeutics to improve their pharmacological potential…”
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Influence of Sugar Modifications on the Nucleoside Conformation and Oligonucleotide Stability: A Critical Review by Das, Gourav, Harikrishna, S., Gore, Kiran R.

“…Ribofuranose sugar conformation plays an important role in the structure and dynamics of functional nucleic acids such as siRNAs, AONs, aptamers, miRNAs, etc…”
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Selective Recognition of the Dimeric NG16 Parallel G‑Quadruplex Structure Using Synthetic Turn-On Red Fluorescent Protein Chromophore by Choudhary, Nishant Kumar, Gupta, Shalini, Das, Gourav, Sahoo, Avijit, Harikrishna, S., Sinha, Surajit, Gore, Kiran R.

“…Red fluorescent protein (RFP)-based fluorescent probes that can selectively interact with specific nucleic acids are of great importance for therapeutic and…”
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Synthesis, Structural, and Conformational Analysis of 4′‐C‐Alkyl‐2′‐O‐Ethyl‐Uridine Modified Nucleosides by Nikam, Rahul R., Harikrishna, S., Gore, Kiran R.

“…Sugar modifications have attracted much attention due to their potential structural and functional influence on therapeutic nucleic acids. Herein, we report…”
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4′‑C‑Acetamidomethyl-2′‑O‑methoxyethyl Nucleic Acid Modifications Improve Thermal Stability, Nuclease Resistance, Potency, and hAgo2 Binding of Small Interfering RNAs by Gangopadhyay, Sumit, Das, Gourav, Gupta, Shalini, Ghosh, Atanu, Bagale, Siddharam Shivappa, Roy, Pritam Kumar, Mandal, Mahitosh, Harikrishna, S., Sinha, Surajit, Gore, Kiran R.

“…In this study, we designed the 4′-C-acetamidomethyl-2′-O-methoxyethyl (4′-C-ACM-2′-O-MOE) uridine and thymidine modifications, aiming to test them into small…”
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Synthesis of N 3 -Methyluridine- and 2'-O-Alkyl/2'-Fluoro-N 3 -Methyluridine-Modified Phosphoramidites and Their Incorporation into DNA and RNA Oligonucleotides by Sahoo, Avijit, Gore, Kiran R

“…In this article, we describe the synthesis of N -methyluridine (m U) and 2'-O-alkyl/2'-fluoro-N -methyluridine (2'-O-alkyl/2'-F-m U) phosphoramidites as well…”
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Vinyl substituted triphenylamine based turn-off fluorescent probe for selective and sensitive detection of mercury (II) in water and live cells by Choudhary, Nishant Kumar, Mittapelli, Lavanya L., Kumar Roy, Pritam, Das, Gourav, Mandal, Mahitosh, Gore, Kiran R.

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LiHMDS: Facile, highly efficient and metal-free transesterification under solvent-free condition by Mittapelli, Lavanya L., Gore, Kiran R.

“…Transesterification is one of the important organic reactions employed in numerous industrial as well as laboratory applications for the synthesis of various…”
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2′‑O‑Alkyl‑N 3‑Methyluridine Functionalized Passenger Strand Improves RNAi Activity by Modulating the Thermal Stability by Sahoo, Avijit, Gupta, Shalini, Das, Gourav, Ghosh, Atanu, Bagale, Siddharam Shivappa, Sinha, Surajit, Gore, Kiran R.

“…Herein, we have demonstrated that the siRNA activity could be enhanced by incorporating the guide strand in the RISC complex through thermodynamic asymmetry…”
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N3-Methyluridine and 2′-O-Alkyl/2′-Fluoro-N3-methyluridine functionalized nucleic acids improve nuclease resistance while maintaining duplex geometry by Sahoo, Avijit, Das, Gourav, Ghosh, Atanu, Shivappa Bagale, Siddharam, Kumar Choudhary, Nishant, Harikrishna, S., Sinha, Surajit, Gore, Kiran R.

“…Oligonucleotides containing chemical modification including m3U and 2′-O-alkyl substituted m3U with increasing chain length (methyl to propyl/MOE) were…”
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A turn-on fluorescent GFP chromophore analog for highly selective and efficient detection of H2S in aqueous and in living cells by Mittapelli, Lavanya L., Nawale, Ganesh N., Gholap, Sachin P., Varghese, Oommen P., Gore, Kiran R.

“…[Display omitted] •Novel synthetic acryloyl protected GFP chromophore based H2S chemodosimeter.•Rapid, selective and sensitive detection of H2S over wide range…”
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Synthetic green fluorescent protein (GFP) chromophore analog for rapid, selective and sensitive detection of cyanide in water and in living cells by Mirajkar, Abhishek L., Mittapelli, Lavanya L., Nawale, Ganesh N., Gore, Kiran R.

“…[Display omitted] •THBI is a novel synthetic GFP chromophore analog for rapid (in less than 5 s) detection of cyanide in water.•The probe exhibited excellent…”
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A mild and convenient approach for selective acetonide cleavage involved in carbohydrate synthesis using PPA-SiO2 by Nikam, Rahul R., Gore, Kiran R.

“…Here, we report a highly selective, efficient and rapid method for the selective cleavage of primary acetonide using silica supported polyphosphoric acid…”
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Design, synthesis, biophysical and primer extension studies of novel acyclic butyl nucleic acid (BuNA) by Kumar, Vipin, Gore, Kiran R, Pradeepkumar, P I, Kesavan, Venkitasamy

“…A novel nucleic acid analogue called acyclic (S)-butyl nucleic acid (BuNA) composed of an acyclic backbone containing a phosphodiester linkage and bearing…”
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Unique Structural Features in DNA Polymerase IV Enable Efficient Bypass of the N 2 Adduct Induced by the Nitrofurazone Antibiotic by Kottur, Jithesh, Sharma, Amit, Gore, Kiran R., Narayanan, Naveen, Samanta, Biswajit, Pradeepkumar, Pushpangadan I., Nair, Deepak T.

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