Search Results - "Gordon Lindsay, J."

Improved Catenated Structures of Bovine Peroxiredoxin III F190L Reveal Details of Ring-Ring Interactions and a Novel Conformational State by Cao, Zhenbo, McGow, Donna P, Shepherd, Colin, Lindsay, J Gordon

“…Mitochondrial 2-cys peroxiredoxin III (PrxIII) is a key player in antioxidant defence reducing locally-generated H2O2 to H2O. A Phe to Leu (F190L) mutation in…”
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Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly by Vijayakrishnan, Swetha, Callow, Philip, Nutley, Margaret A, McGow, Donna P, Gilbert, David, Kropholler, Peter, Cooper, Alan, Byron, Olwyn, Lindsay, J Gordon

“…Crucial to glucose homoeostasis in humans, the hPDC (human pyruvate dehydrogenase complex) is a massive molecular machine comprising multiple copies of three…”
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Bovine Mitochondrial Peroxiredoxin III Forms a Two-Ring Catenane by Cao, Zhenbo, Roszak, Aleksander W., Gourlay, Louise J., Lindsay, J. Gordon, Isaacs, Neil W.

“…A crystal structure is reported for the C168S mutant of a typical 2-Cys peroxiredoxin III (Prx III) from bovine mitochondria at a resolution of 3.3 Å. Prx III…”
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Reconstitution of the Mitochondrial PrxIII Antioxidant Defence Pathway: General Properties and Factors Affecting PrxIII Activity and Oligomeric State by Cao, Zhenbo, Bhella, David, Lindsay, J. Gordon

“…The mitochondrial 2-Cys peroxiredoxin PrxIII serves as a thioredoxin-dependent peroxidase operating in tandem with its cognate partners, an organelle-specific…”
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Metabolic Impairment Induces Oxidative Stress, Compromises Inflammatory Responses, and Inactivates a Key Mitochondrial Enzyme in Microglia by Park, Larry C. H., Zhang, Hui, Sheu, Kwan‐Fu Rex, Calingasan, Noel Y., Kristal, Bruce S., Gordon Lindsay, J., Gibson, Gary E.

“…: Microglial activation, oxidative stress, and dysfunctions in mitochondria, including the reduction of cytochrome oxidase activity, have been implicated in…”
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Mitochondrial Stress Protein Recognition of Inactivated Dehydrogenases during Mammalian Cell Death by Bruschi, Sam A., Lindsay, J. Gordon, Crabb, John W.

“…The mammalian renal toxicant tetrafluoroethylcysteine (TFEC) is metabolized to a reactive intermediate that covalently modifies the lysine residues of a select…”
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Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of α-ketoglutarate dehydrogenase by Waagepetersen, Helle S., Hansen, Gert H., Fenger, Kirsten, Lindsay, J. Gordon, Gibson, Gary, Schousboe, Arne

“…In brain cells, various metabolites and metabolic pathways, largely of mitochondrial origin, have been shown to be compartmentalized. Attention has therefore…”
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Bacterial cytochromes P-450 by Munro, A W, Lindsay, J G

“…The cytochromes P-450 (P-450s) constitute an extremely large family ('superfamily') of haemoproteins that catalyse the oxidation of a wide range of…”
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Structure-function analysis of recombinant substrate protein 22 kDa (SP-22). A mitochondrial 2-CYS peroxiredoxin organized as a decameric toroid by Gourlay, Louise J, Bhella, David, Kelly, Sharon M, Price, Nicholas C, Lindsay, J Gordon

“…Bovine mitochondrial SP-22 is a member of the peroxiredoxin family of peroxidases. It belongs to the peroxiredoxin 2-Cys subgroup containing three cysteines at…”
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Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity by Moreau, Régis, Heath, Shi-Hua D, Doneanu, Catalin E, Lindsay, J Gordon, Hagen, Tory M

“…4-hydroxynonenal (HNE), a product of omega-6 polyunsaturated fatty acid peroxidation, impairs mitochondrial respiration in vitro by adducting the…”
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Membrane dihydrolipoamide acetyltransferase (E2) on human biliary epithelial cells in primary biliary cirrhosis by Joplin, R, Lindsay, J G, Johnson, G D, Strain, A, Neuberger, J

“…Primary biliary cirrhosis (PBC) is associated with serum antibodies that react with the dihydrolipoamide acetyltransferase component (E2) of the mitochondrial…”
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FAD Insertion Is Essential for Attaining the Assembly Competence of the Dihydrolipoamide Dehydrogenase (E3) Monomer fromEscherichia coli by Lindsay, Heather, Beaumont, Ellen, Richards, Susan D., Kelly, Sharon M., Sanderson, Sanya J., Price, Nicholas C., Lindsay, J. Gordon

“…Dihydrolipoamide dehydrogenase (E3) fromEscherichia coli, an FAD-linked homodimer, can be fully reconstituted in vitro following denaturation in 6m guanidinium…”
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Refolding and Reconstitution Studies on the Transacetylase−Protein X (E2/X) Subcomplex of the Mammalian Pyruvate Dehydrogenase Complex:  Evidence for Specific Binding of the Dihydrolipoamide Dehydrogenase Component to Sites on Reassembled E2 by McCartney, R. Graham, Sanderson, Sanya J, Lindsay, J. Gordon

“…Reconstitution studies have been conducted on the dihydrolipoamide acetyltransferase−protein X core subcomplex of the mammalian pyruvate dehydrogenase complex…”
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Structural and enzymological analysis of the interaction of isolated domains of cytochrome P-450 BM3 by Munro, Andrew W., Lindsay, J.Gordon, Coggins, John R., Kelly, Sharon M., Price, Nicholas C.

“…The interactions of the individually expressed haem- and flavin-containing domains of cytochrome P-450 BM3 have been analysed by enzymological and…”
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Distribution of pyruvate dehydrogenase dihydrolipoamide acetyltransferase (PDC-E2) and another mitochondrial marker in salivary gland and biliary epithelium from patients with primary biliary cirrhosis by Joplin, R E, Johnson, G D, Matthews, J B, Hamburger, J, Lindsay, J G, Hubscher, S G, Strain, A J, Neuberger, J M

“…Previous studies in which quantitative immunofluorescence was used have shown that certain biliary epithelial cells in liver with primary biliary cirrhosis…”
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Distribution of dihydrolipoamide acetyltransferase (E2) in the liver and portal lymph nodes of patients with primary biliary cirrhosis: an immunohistochemical study by Joplin, R, Lindsay, J G, Hubscher, S G, Johnson, G D, Shaw, J C, Strain, A J, Neuberger, J M

“…The reason for the close association between primary biliary cirrhosis and the appearance of antibodies that recognize the E2 component of pyruvate…”
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Sequences directing dihydrolipoamide dehydrogenase (E3) binding are located on the 2‐oxoglutarate dehydrogenase (E1) component of the mammalian 2‐oxoglutarate dehydrogenase multienzyme complex by Rice, J.E., Dunbar, B., Lindsay, J.G.

“…Sequences located in the N‐terminal region of the high M(r) 2‐oxoglutarate dehydrogenase (E1) enzyme of the mammalian 2‐oxoglutarate dehydrogenase multienzyme…”
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Autoantibodies in primary biliary cirrhosis: analysis of reactivity against eukaryotic and prokaryotic 2-oxo acid dehydrogenase complexes by Fussey, S P, Lindsay, J G, Fuller, C, Perham, R N, Dale, S, James, O F, Bassendine, M F, Yeaman, S J

“…Six components of the mammalian 2-oxo acid dehydrogenase complexes have previously been identified as M2 autoantigens in primary biliary cirrhosis. In this…”
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Inhibition of flavin reoxidation in P450 BM3 by diphenyliodonium chloride by Munro, A W, Coggins, J R, Lindsay, J G

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Analysis of the structural stability of the multidomain enzyme flavocytochrome P-450 BM3 by Munro, Andrew W., Gordon Lindsay, J., Coggins, John R., Kelly, Sharon M., Price, Nicholas C.

“…The unfolding and refolding of flavocytochrome P-450 BM3 and its constituent haem and flavin domains have been analysed, using guanidinium chloride (GdnHCl) as…”
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