Search Results - "Gordon‐Smith, E. C."

The effect of treatment with Campath‐1H in patients with autoimmune cytopenias by Willis, F., Marsh, J. C. W., Bevan, D. H., Killick, S. B., Lucas, G., Griffiths, R., Ouwehand, W., Hale, G., Waldmann, H., Gordon‐smith, E. C.

“…We describe 21 patients with severe and life‐threatening autoimmune cytopenias resistant to standard immunosuppression who were treated with the monoclonal…”
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Guidelines for the diagnosis and management of acquired aplastic anaemia by Marsh, J.C.W., Ball, S.E., Darbyshire, P., Gordon‐Smith, E.C., Keidan, A.J., Martin, A., McCann, S.R., Mercieca, J., Oscier, D., Roques, A.W.W., Yin, J.A.L.

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Increased apoptosis of bone marrow CD34+ cells and impaired function of bone marrow stromal cells in patients with systemic lupus erythematosus by Papadaki, Helen A., Boumpas, Dimitrios T., Gibson, Frances M., Jayne, David R., Axford, John S., Gordon‐Smith, E. C., Marsh, Judith C. W., Eliopoulos, George D.

“…The changes in bone marrow (BM) stem cell reserve and function and stromal cell function in patients with active systemic lupus erythematosus (SLE) were…”
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Marrow transplants from matched unrelated donors for aplastic anaemia using alemtuzumab, fludarabine and cyclophosphamide based conditioning by GUPTA, V, BALL, S. E, SAGE, D, ORTIN, M, FREIRES, M, GORDON-SMITH, E. C, MARSH, J. C. W

“…Graft failure, regimen-related toxicity and graft-versus-host disease (GVHD) are the critical barriers to unrelated donor transplants for aplastic anaemia…”
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The role of occupational and environmental exposures in the aetiology of acquired severe aplastic anaemia: a case control investigation by Muir, K. R., Chilvers, C. E. D., Harriss, C., Coulson, L., Grainge, M., Darbyshire, P., Geary, C., Hows, J., Marsh, J., Rutherford, T., Taylor, M., Gordon‐Smith, E. C.

“…Aplastic anaemia is a rare but serious disorder with a high morbidity and mortality rate. The causes of aplastic anaemia are, for the most part, unknown. We…”
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The Use of 7-Amino Actinomycin D in Identifying Apoptosis: Simplicity of Use and Broad Spectrum of Application Compared With Other Techniques by Philpott, N.J., Turner, A.J.C., Scopes, J., Westby, M., Marsh, J.C.W., Gordon-Smith, E.C., Dalgleish, A.G., Gibson, F.M.

“…The detection and quantitation of apoptotic cells is becoming increasingly important in the investigation of the role of apoptosis in cellular proliferation…”
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Diamond-Blackfan anaemia in the U.K.: analysis of 80 cases from a 20-year birth cohort by Ball, S E, McGuckin, C P, Jenkins, G, Gordon-Smith, E C

“…The U.K. Diamond-Blackfan Anaemia (DBA) Registry was established with the aim of providing a representative database for studies on the aetiology,…”
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Relapse of severe aplastic anaemia after influenza immunization by Hendry, C. L., Sivakumaran, M., Marsh, J. C. W., Gordon‐Smith, E. C.

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Mechanisms of bone marrow progenitor cell apoptosis in aplastic anaemia and the effect of anti-thymocyte globulin : examination of the role of the Fas-Fas-L interaction by KILLICK, S. B, COX, C. V, MARSH, J. C. W, GORDON-SMITH, E. C, GIBSON, F. M

“…The mechanism of action of anti-thymocyte globulin (ATG) in aplastic anaemia (AA) is complex. Bone marrow (BM) CD34(+) cells in AA have been shown to be more…”
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Bcl‐2 and Bcl‐x expression in the CD34+ cells of aplastic anaemia patients: relationship with increased apoptosis and upregulation of Fas antigen by Ismail, M., Gibson, F. M., Gordon‐Smith, E. C., Rutherford, T. R.

“…Aplastic anaemia (AA) is a syndrome of haemopoietic failure involving increased apoptosis in stem cells. AA CD34+ cells often have upregulated Fas antigen, but…”
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Serum thrombopoietin levels in patients with aplastic anaemia by Marsh, J C, Gibson, F M, Prue, R L, Bowen, A, Dunn, V T, Hornkohl, A C, Nichol, J L, Gordon-Smith, E C

“…Endogenous serum thrombopoietin (TPO) levels were measured in 31 patients with aplastic anaemia (AA) using an enzyme immunoassay with a sensitivity of 20 pg/…”
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The sensitivity of Fanconi anaemia group C cells to apoptosis induced by mitomycin C is due to oxygen radical generation, not DNA crosslinking by CLARKE, A. A., PHILPOTT, N. J., GORDON‐SMITH, E. C., RUTHERFORD, T. R.

“…Fanconi's anaemia (FA) is characterized by increased spontaneous and induced chromosome fragility. This has been widely regarded to be due to a defect in DNA…”
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Abnormal cytogenetic clones in patients with aplastic anaemia: response to immunosuppressive therapy by Geary, C. G., Harrison, C. J., Philpott, N. J., Hows, J. M., Gordon‐Smith, E. C., Marsh, J. C. W.

“…We report the response to immunosuppressive therapy with antithymocyte globulin (ATG) and cyclosporin or oxymetholone in 13 cases of aplastic anaemia (AA) with…”
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Implications of CD34+ cell dose on clinical and haematological outcome of allo-SCT for acquired aplastic anaemia by Islam, M S, Anoop, P, Datta-Nemdharry, P, Sage, D, Gordon-Smith, E C, Turner, D, Wiltshire, S, O'Regan, L, Marsh, J C W

“…The precise effects of CD34+ cell dose on the outcome of allogeneic transplantation for aplastic anaemia (AA) are not known. Previous studies have used the…”
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Lack of clinical efficacy of rituximab in the treatment of autoimmune neutropenia and pure red cell aplasia: implications for their pathophysiology by Dungarwalla, M, Marsh, J C W, Tooze, J A, Lucas, G, Ouwehand, W, Pettengell, R, Dearden, C E, Gordon Smith, E C, Elebute, M O

“…We describe 11 patients with severe refractory autoimmune cytopenias treated with the anti-CD20 monoclonal antibody rituximab. Six patients had autoimmune…”
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Remission induced by Campath-1H for thymoma-associated agranulocytosis by Alvares, C L, Svasti-Salee, D, Rowley, M, Gordon-Smith, E C, Marsh, J C W

“…Thymoma-associated agranulocytosis is a rare but almost universally fatal condition. Reports to date have described several immunosuppressive therapies…”
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N-RAS gene mutation in patients with aplastic anemia and aplastic anemia/ paroxysmal nocturnal hemoglobinuria during evolution to clonal disease by MORTAZAVI, Y, TOOZE, J. A, GORDON-SMITH, E. C, RUTHERFORD, T. R

“…Long-term survivors of aplastic anemia (AA) have a high incidence of clonal disorders, in particular paroxysmal nocturnal hemoglobinuria (PNH), myelodysplastic…”
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Study of the association between cytochromes P450 2D6 and 2E1 genotypes and the risk of drug and chemical induced idiosyncratic aplastic anaemia by Marsh, J. C. W., Chowdry, J., Parry‐Jones, N., Ellis, S. W., Muir, K. R., Gordon‐Smith, E. C., Tucker, G. T.

“…A genetic susceptibility to drug or chemical toxicity may provide a basis for an increased risk of idiosyncratic aplastic anaemia (AA). The cytochrome P450…”
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Sustained remission of severe resistant autoimmune neutropenia with Campath‐1H by Killick, S. B., Marsh, J. C. W., Hale, G., Waldmann, H., Kelly, S. J., Gordon‐Smith, E. C.

“…We report the course of a patient with severe autoimmune neutropenia in whom only transient responses occurred with corticosteroids, antilymphocyte globulin…”
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Progressive telomere shortening in aplastic anemia by BALL, S. E, GIBSON, F. M, RIZZO, S, TOOZE, J. A, MARSH, J. C. W, GORDON-SMITH, E. C

“…Improved survival in aplastic anemia (AA) has shown a high incidence of late clonal marrow disorders. To investigate whether accelerated senescence of…”
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