Search Results - "Gordon, Nathaniel C."

Engineering an APRIL-specific B Cell Maturation Antigen by Patel, Darshana R., Wallweber, Heidi J.A., Yin, JianPing, Shriver, Stephanie K., Marsters, Scot A., Gordon, Nathaniel C., Starovasnik, Melissa A., Kelley, Robert F.

“…B cell maturation antigen (BCMA) is a tumor necrosis factor receptor family member whose physiological role remains unclear. BCMA has been implicated as a…”
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Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding by Hymowitz, Sarah G, Patel, Darshana R, Wallweber, Heidi J A, Runyon, Steven, Yan, Minhong, Yin, Jianping, Shriver, Stephanie K, Gordon, Nathaniel C, Pan, Borlan, Skelton, Nicholas J, Kelley, Robert F, Starovasnik, Melissa A

“…TACI is a member of the tumor necrosis factor receptor superfamily and serves as a key regulator of B cell function. TACI binds two ligands, APRIL and BAFF,…”
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Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells by Lee, Chingwei V., Hymowitz, Sarah G., Wallweber, Heidi J., Gordon, Nathaniel C., Billeci, Karen L., Tsai, Siao-Ping, Compaan, Deanne M., Yin, JianPing, Gong, Qian, Kelley, Robert F., DeForge, Laura E., Martin, Flavius, Starovasnik, Melissa A., Fuh, Germaine

“…BR3, which is expressed on all mature B cells, is a specific receptor for the B-cell survival and maturation factor BAFF (B-cell–activating factor belonging to…”
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Multiple Novel Classes of APRIL-specific Receptor-blocking Peptides Isolated by Phage Display by Gordon, Nathaniel C., Lien, Samantha, Johnson, Jeremy, Wallweber, Heidi J.A., Tran, Thuy, Currell, Bridget, Mathieu, Mary, Quan, Clifford, Starovasnik, Melissa A., Hymowitz, Sarah G., Kelley, Robert F.

“…A proliferation-inducing ligand (APRIL) is a member of the tumor necrosis factor (TNF) ligand superfamily and has a proliferative effect on both normal and…”
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The PYRIN domain: A member of the death domain‐fold superfamily by Fairbrother, Wayne J., Gordon, Nathaniel C., Humke, Eric W., O'Rourke, Karen M., Starovasnik, Melissa A., Yin, Jian‐Ping, Dixit, Vishva M.

“…PYRIN domains were identified recently as putative protein–protein interaction domains at the N‐termini of several proteins thought to function in apoptotic…”
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Combinatorial Screening Identifies Novel Promiscuous Matrix Metalloproteinase Activities that Lead to Inhibition of the Therapeutic Target IL-13 by Urbach, Carole, Gordon, Nathaniel C., Strickland, Ian, Lowne, David, Joberty-Candotti, Cathy, May, Richard, Herath, Athula, Hijnen, DirkJan, Thijs, Judith L., Bruijnzeel-Koomen, Carla A., Minter, Ralph R., Hollfelder, Florian, Jermutus, Lutz

“…The practical realization of disease modulation by catalytic degradation of a therapeutic target protein suffers from the difficulty to identify candidate…”
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BAFF/BLyS Receptor 3 Comprises a Minimal TNF Receptor-like Module That Encodes a Highly Focused Ligand-Binding Site by Gordon, Nathaniel C., Pan, Borlan, Hymowitz, Sarah G., Yin, Kelley, Robert F., Cochran, Andrea G., Yan, Minhong, Dixit, Vishva M., Fairbrother, Wayne J., Starovasnik, Melissa A.

“…BAFF/BLyS, a member of the tumor necrosis family (TNF) superfamily of ligands, is a crucial survival factor for B cells. BAFF binds three receptors, TACI,…”
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Structures of APRIL-Receptor Complexes by Hymowitz, Sarah G., Patel, Darshana R., Wallweber, Heidi J.A., Runyon, Steven, Yan, Minhong, Yin, JianPing, Shriver, Stephanie K., Gordon, Nathaniel C., Pan, Borlan, Skelton, Nicholas J., Kelley, Robert F., Starovasnik, Melissa A.

“…TACI is a member of the tumor necrosis factor receptor superfamily and serves as a key regulator of B cell function. TACI binds two ligands, APRIL and BAFF,…”
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High-Level Bacterial Expression and 15N-Alanine-Labeling of Bovine Trypsin. Application to the Study of Trypsin−Inhibitor Complexes and Trypsinogen Activation by NMR Spectroscopy by Peterson, Francis C, Gordon, Nathaniel C, Gettins, Peter G. W

“…We describe here the high-level expression of bovine trypsinogen in E. coli, its refolding and activation to β-trypsin, and the selective incorporation of…”
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Formation of a Noncovalent Serpin-Proteinase Complex Involves No Conformational Change in the Serpin. Use of 1H-15N HSQC NMR as a Sensitive Nonperturbing Monitor of Conformation by Peterson, Francis C, Gordon, Nathaniel C, Gettins, Peter G. W

“…A structural understanding of the nature and scope of serpin inhibition mechanisms has been limited by the inability so far to crystallize any…”
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BAFF/BLyS Receptor 3 Binds the B Cell Survival Factor BAFF Ligand through a Discrete Surface Loop and Promotes Processing of NF-κB2 by Kayagaki, Nobuhiko, Yan, Minhong, Seshasayee, Dhaya, Wang, Hua, Lee, Wyne, French, Dorothy M., Grewal, Iqbal S., Cochran, Andrea G., Gordon, Nathaniel C., Yin, JianPing, Starovasnik, Melissa A., Dixit, Vishva M.

“…The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes…”
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High-Level Bacterial Expression and 15 N-Alanine-Labeling of Bovine Trypsin. Application to the Study of Trypsin−Inhibitor Complexes and Trypsinogen Activation by NMR Spectroscopy by Peterson, Francis C., Gordon, Nathaniel C., Gettins, Peter G. W.

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Formation of a Noncovalent Serpin-Proteinase Complex Involves No Conformational Change in the Serpin. Use of 1 H- 15 N HSQC NMR as a Sensitive Nonperturbing Monitor of Conformation by Peterson, Francis C., Gordon, Nathaniel C., Gettins, Peter G. W.

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Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells. Commentary by RADER, Christoph, BARBAS, Carlos F, QIAN GONG, KELLEY, Robert F, DEFORGE, Laura E, MARTIN, Flavius, STAROVASNIK, Melissa A, FUH, Germaine, LEE, Chingwei V, HYMOWITZ, Sarah G, WALLWEBER, Heidi J, GORDON, Nathaniel C, BILLECI, Karen L, TSAI, Siao-Ping, COMPAAN, Deanne M, JIANPING YIN

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BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2 by Kayagaki, Nobuhiko, Yan, Minhong, Seshasayee, Dhaya, Wang, Hua, Lee, Wyne, French, Dorothy M, Grewal, Iqbal S, Cochran, Andrea G, Gordon, Nathaniel C, Yin, JianPing, Starovasnik, Melissa A, Dixit, Vishva M

“…The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes…”
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BAFF/BLyS Receptor 3 Binds the B Cell Survival Factor BAFF Ligand through a Discrete Surface Loop and Promotes Processing of NF-[kappa]B2 by Kayagaki, Nobuhiko, Yan, Minhong, Seshasayee, Dhaya, Wang, Hua, Lee, Wyne, French, Dorothy M, Grewal, Iqbal S, Cochran, Andrea G, Gordon, Nathaniel C, Yin, JianPing, Starovasnik, Melissa A, Dixit, Vishva M

“…The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes…”
Get full text