Search Results - "Gordon, K.C."

Application of terahertz pulsed imaging to analyse film coating characteristics of sustained-release coated pellets by Haaser, M., Karrout, Y., Velghe, C., Cuppok, Y., Gordon, K.C., Pepper, M., Siepmann, J., Rades, T., Taday, P.F., Strachan, C.J.

“…Terahertz pulsed imaging (TPI) was employed to explore its suitability for detecting differences in the film coating thickness and drug layer uniformity of…”
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Rapid whole-exome sequencing facilitates precision medicine in paediatric rare disease patients and reduces healthcare costs by Chung, Claudia C.Y., Leung, Gordon K.C., Mak, Christopher C.Y., Fung, Jasmine L.F., Lee, Mianne, Pei, Steven L.C., Yu, Mullin H.C., Hui, Vivian C.C., Chan, Joshua C.K., Chau, Jeffrey F.T., Chan, Marcus C.Y., Tsang, Mandy H.Y., Wong, Wilfred H.S., Tung, Joanna Y.L., Lun, Kin Shing, Ng, Yiu Ki, Fung, Cheuk Wing, Wong, Mabel S.C., Wong, Rosanna M.S., Lau, Yu Lung, Chan, Godfrey C.F., Lee, So Lun, Yeung, Kit San, Chung, Brian H.Y.

“…Rapid whole-exome sequencing (rWES) offers the potential for early diagnosis-predicated precision medicine. Previous evidence focused predominantly on infants…”
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Analysis of sustained-release tablet film coats using terahertz pulsed imaging by Ho, L., Müller, R., Römer, M., Gordon, K.C., Heinämäki, J., Kleinebudde, P., Pepper, M., Rades, T., Shen, Y.C., Strachan, C.J., Taday, P.F., Zeitler, J.A.

“…The coating quality of a batch of lab-scale, sustained-release coated tablets was analysed by terahertz pulsed imaging (TPI). Terahertz radiation (2 to 120 cm…”
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Diagnostic value of whole‐exome sequencing in Chinese pediatric‐onset neuromuscular patients by Tsang, Mandy H. Y., Chiu, Annie T. G., Kwong, Bernard M. H., Liang, Rui, Yu, Mullin H. C., Yeung, Kit‐San, Ho, Wetor H. L., Mak, Christopher C. Y., Leung, Gordon K. C., Pei, Steven L. C., Fung, Jasmine L. F., Wong, Virginia C. N., Muntoni, Francesco, Chung, Brian H. Y., Chan, Sophelia H. S.

“…Background Neuromuscular disorders (NMDs) comprise a group of heterogeneous genetic diseases with a broad spectrum of overlapping the clinical presentations…”
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Characterizing the conversion kinetics of carbamazepine polymorphs to the dihydrate in aqueous suspension using Raman spectroscopy by Tian, F., Zeitler, J.A., Strachan, C.J., Saville, D.J., Gordon, K.C., Rades, T.

“…In an aqueous environment, polymorphic forms I–III of carbamazepine all convert to the dihydrate. This study investigated the conversion of each polymorphic…”
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Before and after – Nutritional transformation of dysmorphism in a case of Costello syndrome by Chiu, Annie T.G, Zhu, Lixing, Mok, Gary T.K, Leung, Gordon K.C, Chow, C.B, Chung, Brian H.Y

“…Abstract Costello syndrome is a type of RASopathy mapped to HRAS gene in chromosome 11, characterized by prenatal overgrowth, postnatal failure to thrive,…”
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Influence of sample characteristics on quantification of carbamazepine hydrate formation by X-ray powder diffraction and Raman spectroscopy by Tian, F., Zhang, F., Sandler, N., Gordon, K.C., McGoverin, C.M., Strachan, C.J., Saville, D.J., Rades, T.

“…This study aimed to assess the suitability of two widely utilized solid state characterization techniques namely powder X-ray diffraction (XRPD) and Raman…”
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CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis by Leung, Gordon K. C., Ying, Dingge, Mak, Christopher C. Y., Chen, Xin‐Ying, Xu, Weiyi, Yeung, Kit‐San, Wong, Wai‐Lap, Chu, Yoyo W. Y., Mok, Gary T. K., Chau, Christy S. K., McLuskey, Jenna, Ong, Winnie P. T., Leong, Huey‐Yin, Chan, Kelvin Y. K., Yang, Wanling, Chen, Jeng‐Haur, Li, Albert M., Sham, Pak C., Lau, Yu‐Lung, Chung, Brian H. Y., Lee, So‐Lun

“…Background Cystic fibrosis (CF) is a rare condition in Asians. Since 1985, only about 30 Chinese patients have been reported with molecular confirmation…”
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Forecasting cargo growth and regional role of the port of Hong Kong by Seabrooke, William, Hui, Eddie C.M, Lam, William H.K, Wong, Gordon K.C

“…The port of Hong Kong is a critical component of both the city’s and the region’s economy. However, forecasts of cargo growth and development of the port of…”
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Oral health status of southern Chinese following head and neck irradiation therapy for nasopharyngeal carcinoma by Schwarz, Eli, Chiu, Gordon K.C, Keung Leung, W

“…Objective: To investigate the oral health status of patients with nasopharyngeal carcinoma (NPC) after completion of radiotherapy. Methods: Thirty-three NPC…”
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Non-invasive spectroscopic and imaging systems for prediction of beef quality in a meat processing pilot plant by Dixit, Y., Hitchman, S., Hicks, T.M., Lim, P., Wong, C.K., Holibar, L., Gordon, K.C., Loeffen, M., Farouk, M.M., Craigie, C.R., Reis, M.M.

“…This study evaluated a range of diffuse reflectance spectroscopic (Vis-NIR spectrophotometers) and imaging (Hyperspectral imaging cameras) instruments for…”
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The thermo-tectonic evolution of the actively exhuming Mai'iu Fault footwall – Suckling-Dayman metamorphic core complex – in the Woodlark Rift of Papua New Guinea by Österle, J.E., Seward, D., Stockli, D.F., Little, T.A., Rooney, J.S., Gordon, S.M., Smith, E., Gordon, K.C.

“…The Mai'iu Fault in the Woodlark Rift of southeastern Papua New Guinea is an active north-dipping low-angle normal fault (LANF) that has exhumed the…”
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Electronic structure and near-IR transitions of FcC2R and FcC4R dyads by Flood, A.H., McAdam, C.J., Gordon, K.C., Kjaergaard, H.G., Manning, A.M., Robinson, B.H., Simpson, J.

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Noonan syndrome in diverse populations by Kruszka, Paul, Porras, Antonio R., Addissie, Yonit A., Moresco, Angélica, Medrano, Sofia, Mok, Gary T. K., Leung, Gordon K. C., Tekendo‐Ngongang, Cedrik, Uwineza, Annette, Thong, Meow‐Keong, Muthukumarasamy, Premala, Honey, Engela, Ekure, Ekanem N., Sokunbi, Ogochukwu J., Kalu, Nnenna, Jones, Kelly L., Kaplan, Julie D., Abdul‐Rahman, Omar A., Vincent, Lisa M., Love, Amber, Belhassan, Khadija, Ouldim, Karim, El Bouchikhi, Ihssane, Shukla, Anju, Girisha, Katta M., Patil, Siddaramappa J., Sirisena, Nirmala D., Dissanayake, Vajira H. W., Paththinige, C. Sampath, Mishra, Rupesh, Klein‐Zighelboim, Eva, Gallardo Jugo, Bertha E., Chávez Pastor, Miguel, Abarca‐Barriga, Hugo H., Skinner, Steven A., Prijoles, Eloise J., Badoe, Eben, Gill, Ashleigh D., Shotelersuk, Vorasuk, Smpokou, Patroula, Kisling, Monisha S., Ferreira, Carlos R., Mutesa, Leon, Megarbane, Andre, Kline, Antonie D., Kimball, Amy, Okello, Emmy, Lwabi, Peter, Aliku, Twalib, Tenywa, Emmanuel, Boonchooduang, Nonglak, Tanpaiboon, Pranoot, Richieri‐Costa, Antonio, Wonkam, Ambroise, Chung, Brian H. Y., Stevenson, Roger E., Summar, Marshall, Mandal, Kausik, Phadke, Shubha R., Obregon, María G., Linguraru, Marius G., Muenke, Maximilian

“…Noonan syndrome (NS) is a common genetic syndrome associated with gain of function variants in genes in the Ras/MAPK pathway. The phenotype of NS has been well…”
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Raman spectroscopic quantification of milk powder constituents by McGoverin, C.M., Clark, A.S.S., Holroyd, S.E., Gordon, K.C.

“…Raman spectroscopy has significant potential for the quantification of food products. Milk powder is an important foodstuff and ingredient that is produced on…”
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Understanding consolidants on harakeke fibres using Raman microscopy: Implications for conservation by Samanali, G.A.P., Paasi, I., Lowe, B.J., Smith, C.A., Fraser-Miller, S.J., Gordon, K.C.

“…•Raman microscopy combined with chemometric methods can identify consolidant penetration and distribution into muka (Māori textile fibre).•Consolidants…”
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A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35 by Fung, Jasmine L.F., Tsang, Mandy H.Y., Leung, Gordon K.C., Yeung, Kit San, Mak, Christopher C.Y., Fung, Cheuk Wing, Chan, Sophelia H.S., Yu, Mullin H.C., Chung, Brian H.Y.

“…Spinocerebellar ataxia 35 (SCA35) has been associated with pathogenic mutations in the gene TGM6. In a Chinese exome sequencing cohort, we identified 8…”
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Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies by Leung, Gordon K. C., Luk, H. M., Tang, Vincent H. M., Gao, W. W., Mak, Christopher C. Y., Yu, Mullin H. C., Wong, W. L., Chu, Yoyo W. Y., Yang, W. L., Wong, Wilfred H. S., Ma, Alvin C. H., Leung, Anskar Y. H., Jin, D. Y., Chan, Kelvin Y. K., Allanson, Judith, Lo, Ivan F. M., Chung, Brian H. Y.

“…RASopathies are a group of heterogeneous conditions caused by germline mutations in RAS/MAPK signalling pathway genes. With next-generation sequencing (NGS),…”
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Genetic landscape of RASopathies in Chinese: Three decades' experience in Hong Kong by Yu, Kris P. T., Luk, Ho‐Ming, Leung, Gordon K. C., Mak, Christopher C. Y., Cheng, Shirley S. W., Hau, Edgar W. L., Chan, David K. H., Lam, Stephen T. S., Tong, Tony M. F., Chung, Brian H. Y., Lo, Ivan F. M.

“…RASopathies are a group of genetic disorders due to dysregulation of the RAS‐MAPK signaling pathway, which is important in regulating cell growth,…”
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The impact of surface- and nano-crystallisation on the detected amorphous content and the dissolution behaviour of amorphous indomethacin by Priemel, P.A., Grohganz, H., Gordon, K.C., Rades, T., Strachan, C.J.

“…Differences in quantified amorphous content are due to surface- and nano-crystallisation of the samples which are not reflected by the quantification models…”
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