Search Results - "Gordon, Jon W."

Genetically Decreased Spinal Cord Copper Concentration Prolongs Life in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis by Kiaei, Mahmoud, Bush, Ashley I, Morrison, Brett M, Morrison, John H, Cherny, Robert A, Volitakis, Irene, Beal, M. Flint, Gordon, Jon W

“…Mutations in the Cu/Zn superoxide dismutase (SOD1) gene cause familial amyotrophic lateral sclerosis (FALS) by gain of an aberrant function that is not yet…”
Get full text

Direct Exposure of Mouse Ovaries and Oocytes to High Doses of an Adenovirus Gene Therapy Vector Fails to Lead to Germ Cell Transduction by Gordon, Jon W.

“…The risk of insertion of adenovirus gene therapy DNA into female germ cells during the course of somatic gene therapy was stringently tested in the mouse by…”
Get full text

High Toxicity, Low Receptor Density, and Low Integration Frequency Severely Impede the Use of Adenovirus Vectors for Production of Transgenic Mice by Gordon, Jon W

“…Although many methods are available for introducing genes into the mammalian germ line, none is ideal for genetic manipulation of livestock or primates. These…”
Get full text

Differential Screening of Mutated SOD1 Transgenic Mice Reveals Early Up-Regulation of a Fast Axonal Transport Component in Spinal Cord Motor Neurons by Dupuis, Luc, de Tapia, Marc, René, Frédérique, Lutz-Bucher, Bernadette, Gordon, Jon W., Mercken, Luc, Pradier, Laurent, Loeffler, Jean-Philippe

“…In the present study we analyze the molecular mechanisms underlying motor neuron degeneration in familial amyotrophic lateral sclerosis (FALS). For this, we…”
Get full text

Transgenic Mice Expressing an Altered Murine Superoxide Dismutase Gene Provide an Animal Model of Amyotrophic Lateral Sclerosis by Ripps, Michael E., Huntley, George W., Hof, Patrick R., Morrison, John H., Gordon, Jon W.

“…Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder primarily involving motoneurons. A subset of individuals with familial autosomal…”
Get full text

Direct exposure of mouse spermatozoa to very high concentrations of a serotype-2 adeno-associated virus gene therapy vector fails to lead to germ cell transduction by Couto, Linda, Parker, Amy, Gordon, Jon W

“…In a clinical safety trial involving an adeno-associated virus (AAV) gene therapy vector encoding human factor IX, intrahepatic administration of the vector…”
Get more information

Alteration of the Bcl-x/Bax Ratio in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis: Evidence for the Implication of the p53 Signaling Pathway by González de Aguilar, José-Luis, Gordon, Jon W., René, Frédérique, de Tapia, Marc, Lutz-Bucher, Bernadette, Gaiddon, Christian, Loeffler, Jean-Philippe

“…Molecular mechanisms promoting neuronal death in amyotrophic lateral sclerosis (ALS) were investigated using transgenic mice that overexpressed the G86R…”
Get full text

Micromanipulation of gametes and embryos may be a risk for human germ-line gene transfer by Gordon, Jon W

Get more information

Differential vulnerability of oculomotor, facial, and hypoglossal nuclei in G86R superoxide dismutase transgenic mice by Nimchinsky, Esther A., Young, Warren G., Yeung, Glendy, Shah, Ravi A., Gordon, Jon W., Bloom, Floyd E., Morrison, John H., Hof, Patrick R.

“…In recent years, several mouse models of amyotrophic lateral sclerosis (ALS) have been developed. One, caused by a G86R mutation in the superoxide dismutase‐1…”
Get full text

Genetic Enhancement in Humans by Gordon, Jon W.

“…Several scientific and moral issues have arisen from the advancements in research of genetic enhancements and genetic engineering, which include playing with…”
Get full text

Time course of neuropathology in the spinal cord of G86R superoxide dismutase transgenic mice by Morrison, Brett M., Janssen, William G., Gordon, Jon W., Morrison, John H.

“…Transgenic mice with a G86R mutation in the mouse superoxide dismutase (SOD‐1) gene, which corresponds to a mutation observed in familial amyotrophic lateral…”
Get full text

Engineering the Human Germline by Gordon, Jon W.

Get full text

Constitutive Activation of Phototransduction by K296E Opsin is not a Cause of Photoreceptor Degeneration by Li, Tiansen, Franson, Wendy K., Gordon, Jon W., Berson, Eliot L., Dryja, Thaddeus P.

“…The missense mutation Lys-296 → Glu (K296E) in the rhodopsin gene produces an opsin with no chromophore binding site and therefore is not activated by light…”
Get full text

Barrier Facilities for Transgenic Rodents in Academic Centers-A Two-Edged Sword by Gordon, Jon W.

Get full text

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage by Robey, E A, Fowlkes, B J, Gordon, J W, Kioussis, D, von Boehmer, H, Ramsdell, F, Axel, R

“…Immature thymocytes, which coexpress CD4 and CD8, give rise to mature CD4+CD8- and CD4-CD8+ T cells. Only those T cells that recognize self-MHC are selected to…”
Get more information

Early and Selective Pathology of Light Chain Neurofilament in the Spinal Cord and Sciatic Nerve of G86R Mutant Superoxide Dismutase Transgenic Mice by Morrison, Brett M., Shu, I-Wei, Wilcox, Amy L., Gordon, Jon W., Morrison, John H.

“…Pathologic accumulation of neurofilament protein (NF), both within spheroids of the proximal axon and within inclusions of motor neuron somata, is a hallmark…”
Get full text

Ovarian Stimulation of Squirrel Monkeys (Saimiri boliviensis boliviensis) Using Pregnant Mare Serum Gonadotropin by Schuler, Michele A, Westberry, Jenne M, Scammell, Jonathan G, Abee, Christian R, Kuehl, Thomas J, Gordon, Jon W

“…The application of assisted reproductive technologies (ART) to nonhuman primates has created opportunities for improving reproductive management in breeding…”
Get full text

Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor protein by Kawabata, Shigeki, Higgins, Gerald A, Gordon, Jon W

“…Alzheimer's disease (AD) affects more than 30% of people over 80 years of age. The aetiology and pathogenesis of this progressive dementia is poorly…”
Get full text

Cardiac resistance to adriamycin in transgenic mice expressing a rat alpha-cardiac myosin heavy chain/human multiple drug resistance 1 fusion gene by Dell'Acqua, G, Polishchuck, R, Fallon, J T, Gordon, J W

“…Cardiac toxicity is a major factor that limits the use of anthracyclines in cancer chemotherapy. Heart failure frequently develops in patients treated with…”
Get more information

Adenovirus gene transfer vector toxicity to mouse embryos: implications for human IVF by Gordon, Jon W.

“…BACKGROUND: The promulgation and diversification of micromanipulation procedures which open the zona pellucida of the oocyte or early embryo is steadily…”
Get full text