Search Results - "Gordon, Grace"

Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease by Yazar, Seyhan, Alquicira-Hernandez, Jose, Wing, Kristof, Senabouth, Anne, Gordon, M Grace, Andersen, Stacey, Lu, Qinyi, Rowson, Antonia, Taylor, Thomas R P, Clarke, Linda, Maccora, Katia, Chen, Christine, Cook, Anthony L, Ye, Chun Jimmie, Fairfax, Kirsten A, Hewitt, Alex W, Powell, Joseph E

“…The human immune system displays substantial variation between individuals, leading to differences in susceptibility to autoimmune disease. We present…”
Get full text

Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus by Perez, Richard K, Gordon, M Grace, Subramaniam, Meena, Kim, Min Cheol, Hartoularos, George C, Targ, Sasha, Sun, Yang, Ogorodnikov, Anton, Bueno, Raymund, Lu, Andrew, Thompson, Mike, Rappoport, Nadav, Dahl, Andrew, Lanata, Cristina M, Matloubian, Mehrdad, Maliskova, Lenka, Kwek, Serena S, Li, Tony, Slyper, Michal, Waldman, Julia, Dionne, Danielle, Rozenblatt-Rosen, Orit, Fong, Lawrence, Dall'Era, Maria, Balliu, Brunilda, Regev, Aviv, Yazdany, Jinoos, Criswell, Lindsey A, Zaitlen, Noah, Ye, Chun Jimmie

“…Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Knowledge of circulating immune cell types and states associated with SLE remains…”
Get full text

lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements by Gordon, M. Grace, Inoue, Fumitaka, Martin, Beth, Schubach, Max, Agarwal, Vikram, Whalen, Sean, Feng, Shiyun, Zhao, Jingjing, Ashuach, Tal, Ziffra, Ryan, Kreimer, Anat, Georgakopoulos-Soares, Ilias, Yosef, Nir, Ye, Chun Jimmie, Pollard, Katherine S., Shendure, Jay, Kircher, Martin, Ahituv, Nadav

“…Massively parallel reporter assays (MPRAs) can simultaneously measure the function of thousands of candidate regulatory sequences (CRSs) in a quantitative…”
Get full text

Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure by Oelen, Roy, de Vries, Dylan H., Brugge, Harm, Gordon, M. Grace, Vochteloo, Martijn, Ye, Chun J., Westra, Harm-Jan, Franke, Lude, van der Wijst, Monique G. P.

“…The host’s gene expression and gene regulatory response to pathogen exposure can be influenced by a combination of the host’s genetic background, the type of…”
Get full text

SURGE: uncovering context-specific genetic-regulation of gene expression from single-cell RNA sequencing using latent-factor models by Strober, Benjamin J, Tayeb, Karl, Popp, Joshua, Qi, Guanghao, Gordon, M Grace, Perez, Richard, Ye, Chun Jimmie, Battle, Alexis

“…Genetic regulation of gene expression is a complex process, with genetic effects known to vary across cellular contexts such as cell types and environmental…”
Get full text

Prescription Opioid Decision-Making and Use Behaviors in Adolescents with Acute Pain: A Qualitative Study by Kapos, Flavia P, Gordon, Grace O, Groenewald, Cornelius B, Slack, Katherine, Wang, Vienna, Palermo, Tonya M, Wilson, Anna C, Rabbitts, Jennifer A

“…Understanding adolescent perspectives on prescribed opioids in the context of medical care for acute pain is needed to prevent opioid-related adverse outcomes…”
Get full text

Author Correction: lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements by Gordon, M. Grace, Inoue, Fumitaka, Martin, Beth, Schubach, Max, Agarwal, Vikram, Whalen, Sean, Feng, Shiyun, Zhao, Jingjing, Ashuach, Tal, Ziffra, Ryan, Kreimer, Anat, Georgakopoulos-Soares, Ilias, Yosef, Nir, Ye, Chun Jimmie, Pollard, Katherine S., Shendure, Jay, Kircher, Martin, Ahituv, Nadav

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

A suite of automated sequence analyses reduces the number of candidate deleterious variants and reveals a difference between probands and unaffected siblings by Gu, Fangning, Wu, Anchi, Gordon, M. Grace, Vlahos, Lukas, Macnamara, Shane, Burke, Elizabeth, Malicdan, May C., Adams, David R., Tifft, Cynthia J., Toro, Camilo, Gahl, William A., Markello, Thomas C.

“…Purpose Develop an automated exome analysis workflow that can produce a very small number of candidate variants yet still detect different numbers of…”
Get full text

Robust Sequence Determinants of α‑Synuclein Toxicity in Yeast Implicate Membrane Binding by Newberry, Robert W, Arhar, Taylor, Costello, Jean, Hartoularos, George C, Maxwell, Alison M, Naing, Zun Zar Chi, Pittman, Maureen, Reddy, Nishith R, Schwarz, Daniel M. C, Wassarman, Douglas R, Wu, Taia S, Barrero, Daniel, Caggiano, Christa, Catching, Adam, Cavazos, Taylor B, Estes, Laurel S, Faust, Bryan, Fink, Elissa A, Goldman, Miriam A, Gomez, Yessica K, Gordon, M. Grace, Gunsalus, Laura M, Hoppe, Nick, Jaime-Garza, Maru, Johnson, Matthew C, Jones, Matthew G, Kung, Andrew F, Lopez, Kyle E, Lumpe, Jared, Martyn, Calla, McCarthy, Elizabeth E, Miller-Vedam, Lakshmi E, Navarro, Erik J, Palar, Aji, Pellegrino, Jenna, Saylor, Wren, Stephens, Christina A, Strickland, Jack, Torosyan, Hayarpi, Wankowicz, Stephanie A, Wong, Daniel R, Wong, Garrett, Redding, Sy, Chow, Eric D, DeGrado, William F, Kampmann, Martin

“…Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo…”
Get full text

Multi-context genetic modeling of transcriptional regulation resolves novel disease loci by Thompson, Mike, Gordon, Mary Grace, Lu, Andrew, Tandon, Anchit, Halperin, Eran, Gusev, Alexander, Ye, Chun Jimmie, Balliu, Brunilda, Zaitlen, Noah

“…A majority of the variants identified in genome-wide association studies fall in non-coding regions of the genome, indicating their mechanism of impact is…”
Get full text

Population Diversity at the Single-Cell Level by Gordon, M. Grace, Kathail, Pooja, Choy, Bryson, Kim, Min Cheol, Mazumder, Thomas, Gearing, Melissa, Ye, Chun Jimmie

“…Population-scale single-cell genomics is a transformative approach for unraveling the intricate links between genetic and cellular variation. This approach is…”
Get full text

Coordinated, multicellular patterns of transcriptional variation that stratify patient cohorts are revealed by tensor decomposition by Mitchel, Jonathan, Gordon, M Grace, Perez, Richard K, Biederstedt, Evan, Bueno, Raymund, Ye, Chun Jimmie, Kharchenko, Peter V

“…Tissue-level and organism-level biological processes often involve the coordinated action of multiple distinct cell types. The recent application of…”
Get full text

Genetic determinants of co-accessible chromatin regions in activated T cells across humans by Gate, Rachel E., Cheng, Christine S., Aiden, Aviva P., Siba, Atsede, Tabaka, Marcin, Lituiev, Dmytro, Machol, Ido, Gordon, M. Grace, Subramaniam, Meena, Shamim, Muhammad, Hougen, Kendrick L., Wortman, Ivo, Huang, Su-Chen, Durand, Neva C., Feng, Ting, De Jager, Philip L., Chang, Howard Y., Aiden, Erez Lieberman, Benoist, Christophe, Beer, Michael A., Ye, Chun J., Regev, Aviv

“…Over 90% of genetic variants associated with complex human traits map to non-coding regions, but little is understood about how they modulate gene regulation…”
Get full text

Evidence that the 42- and 40-Amino Acid Forms of Amyloid β Protein are Generated from the β -amyloid Precursor Protein by Different Protease Activities by Citron, Martin, Diehl, Thekla S., Gordon, Grace, Biere, Anja Leona, Seubert, Peter, Selkoe, Dennis J.

“…Cerebral deposition of the amyloid β protein (Aβ ) is an early and invariant feature of Alzheimer disease (AD). Whereas the 40-amino acid form of Aβ (Aβ40)…”
Get full text

Trajectories, Risk Factors, and Impact of Persistent Pain After Major Musculoskeletal Surgery in Adolescents: A Replication Study by Ellyson, Alice M, Gordon, Grace, Zhou, Chuan, Rabbitts, Jennifer A

“…Studies have identified high rates of chronic postsurgical pain in adolescents. Characterizing patterns of pain in the transition from acute to chronic…”
Get more information

Building a Digital Entrepreneurial Platform Through Local Community Activity and Digital Skills with Ngemba First Nation, Australia by Beetson, Susan J., Pradhan, Sojen, Gordon, Grace, Ford, Jason

“…In collaboration with Ngemba First Nation in Brewarrina, Australia, this research involves co-designing and co-developing an innovative community digital…”
Get full text

Dysferlin Is a New Marker for Leaky Brain Blood Vessels in Multiple Sclerosis by Hochmeister, Sonja, Grundtner, Roland, Bauer, Jan, Engelhardt, Britta, Lyck, Ruth, Gordon, Grace, Korosec, Thomas, Kutzelnigg, Alexandra, Berger, Johannes J, Bradl, Monika, Bittner, Reginald E, Lassmann, Hans

“…Dysferlin is a muscle protein involved in cell membrane repair and its deficiency is associated with muscular dystrophy. We describe that dysferlin is also…”
Get full text

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse by Schenk, Dale, Barbour, Robin, Dunn, Whitney, Gordon, Grace, Grajeda, Henry, Guido, Teresa, Hu, Kang, Huang, Jiping, Johnson-Wood, Kelly, Khan, Karen, Kholodenko, Dora, Lee, Mike, Liao, Zhenmei, Lieberburg, Ivan, Motter, Ruth, Mutter, Linda, Soriano, Ferdie, Shopp, George, Vasquez, Nicki, Vandevert, Christopher, Walker, Shannan, Wogulis, Mark, Yednock, Ted, Games, Dora, Seubert, Peter

“…Amyloid-β peptide (Aβ) seems to have a central role in the neuropathology of Alzheimer's disease (AD). Familial forms of the disease have been linked to…”
Get full text

Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis by Kamphuis, Sylvia, Kuis, Wietse, de Jager, Wilco, Teklenburg, Gijs, Massa, Margherita, Gordon, Grace, Boerhof, Marjolein, Rijkers, Ger T, Uiterwaal, Cuno S, Otten, Henny G, Sette, Alessandro, Albani, Salvatore, Prakken, Berent J

“…Juvenile idiopathic arthritis is a heterogeneous autoimmune disease characterised by chronic inflammation of one or more joints. In patients with this disease,…”
Get full text

Testis-specific ATP synthase peripheral stalk subunits required for tissue-specific mitochondrial morphogenesis in Drosophila by Sawyer, Eric M, Brunner, Elizabeth C, Hwang, Yihharn, Ivey, Lauren E, Brown, Olivia, Bannon, Megan, Akrobetu, Dennis, Sheaffer, Kelsey E, Morgan, Oshauna, Field, Conroy O, Suresh, Nishita, Gordon, M Grace, Gunnell, E Taylor, Regruto, Lindsay A, Wood, Cricket G, Fuller, Margaret T, Hales, Karen G

“…In Drosophila early post-meiotic spermatids, mitochondria undergo dramatic shaping into the Nebenkern, a spherical body with complex internal structure that…”
Get full text