Search Results - "Gordon, Darren M."

Loss of biliverdin reductase-A promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells by Adeosun, Samuel O, Gordon, Darren M, Weeks, Mary Frances, Moore, Kyle H, Hall, John E, Hinds, Jr, Terry D, Stec, David E

“…Obesity and increased lipid availability have been implicated in the development and progression of chronic kidney disease. One of the major sites of renal…”
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Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate by Hinds, Jr, Terry D, Creeden, Justin F, Gordon, Darren M, Stec, Donald F, Donald, Matthew C, Stec, David E

“…The inverse relationship of plasma bilirubin levels with liver fat accumulation has prompted the possibility of bilirubin as a therapeutic for non-alcoholic…”
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Identification of Binding Regions of Bilirubin in the Ligand-Binding Pocket of the Peroxisome Proliferator-Activated Receptor-A (PPARalpha) by Gordon, Darren M, Hong, Stephen H, Kipp, Zachary A, Hinds, Jr, Terry D

“…Recent work has shown that bilirubin has a hormonal function by binding to the peroxisome proliferator-activated receptor-α (PPARα), a nuclear receptor that…”
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Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice by Stec, David E, Gordon, Darren M, Nestor-Kalinoski, Andrea L, Donald, Matthew C, Mitchell, Zachary L, Creeden, Justin F, Hinds, Jr, Terry D

“…Biliverdin reductase (BVR) is an enzymatic and signaling protein that has multifaceted roles in physiological systems. Despite the wealth of knowledge about…”
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Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1 by Hinds, Jr, Terry D, Creeden, Justin F, Gordon, Darren M, Spegele, Adam C, Britton, Steven L, Koch, Lauren G, Stec, David E

“…Exercise in humans and animals increases plasma bilirubin levels, but the mechanism by which this occurs is unknown. In the present study, we utilized rats…”
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Bilirubin as a metabolic hormone: the physiological relevance of low levels by Creeden, Justin F, Gordon, Darren M, Stec, David E, Hinds, Jr, Terry D

“…Recent research on bilirubin, a historically well-known waste product of heme catabolism, suggests an entirely new function as a metabolic hormone that drives…”
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Loss of hepatic PPARα promotes inflammation and serum hyperlipidemia in diet-induced obesity by Stec, David E, Gordon, Darren M, Hipp, Jennifer A, Hong, Stephen, Mitchell, Zachary L, Franco, Natalia R, Robison, J Walker, Anderson, Christopher D, Stec, Donald F, Hinds, Jr, Terry D

“…Agonists for PPARα are used clinically to reduce triglycerides and improve high-density lipoprotein (HDL) cholesterol levels in patients with hyperlipidemia…”
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RNA sequencing in human HepG2 hepatocytes reveals PPAR-α mediates transcriptome responsiveness of bilirubin by Gordon, Darren M, Blomquist, Thomas M, Miruzzi, Scott A, McCullumsmith, Robert, Stec, David E, Hinds, Jr, Terry D

“…Bilirubin is a potent antioxidant that reduces inflammation and the accumulation of fat. There have been reports of gene responses to bilirubin, which was…”
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Care Patterns and Outcomes for Intrahepatic Cholangiocarcinoma by Rurality of Patient Residence in a Midwestern State by Suraju, Mohammed O, Gordon, Darren M, Kahl, Amanda R, McCracken, Ana, Maduokolam, Erica, Grimmett, Jordan, Guedeze, Komlan, Nash, Sarah, Hassan, Aziz

“…Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy of the liver and has the worst prognosis of any tumor arising from the liver, with a…”
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Evaluation of association between center colorectal neuroendocrine neoplasm volume and survival among patients with colorectal neuroendocrine carcinoma by Suraju, Mohammed O., Freischlag, Kyle, McKeen, Andrew, Nayyar, Apoorve, Thompson, Dakota, Gordon, Darren M., Mishra, Aditi, Sherman, Scott K., Goffredo, Paolo, Hassan, Imran

“…Background Although correlation between center volume and survival has been reported for several complex cancers, it remains unknown if this is true for…”
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Chronic Ethanol Consumption Alters Glucocorticoid Receptor Isoform Expression in Stress Neurocircuits and Mesocorticolimbic Brain Regions of Alcohol-Preferring Rats by Alhaddad, Hasan, Gordon, Darren M., Bell, Richard L., Jarvis, Erin E., Kipp, Zachary A., Hinds, Terry D., Sari, Youssef

“…[Display omitted] •Ethanol exposure reduced GRα in the nucleus NAc shell and hippocampus.•Ethanol exposure reduced GRβ in NAc core, prefrontal cortex and…”
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CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation by Gordon, Darren M., Adeosun, Samuel O., Ngwudike, Somtochukwu I., Anderson, Christopher D., Hall, John E., Hinds, Terry D., Stec, David E.

“…Obesity is the predominant cause of non-alcoholic fatty liver disease (NAFLD), which is associated with insulin resistance and diabetes. NAFLD includes a…”
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Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α by Gordon, Darren M., Neifer, Kari L., Hamoud, Abdul-Rizaq Ali, Hawk, Charles F., Nestor-Kalinoski, Andrea L., Miruzzi, Scott A., Morran, Michael P., Adeosun, Samuel O., Sarver, Jeffrey G., Erhardt, Paul W., McCullumsmith, Robert E., Stec, David E., Hinds, Terry D.

“…Activation of lipid-burning pathways in the fat-storing white adipose tissue (WAT) is a promising strategy to improve metabolic health and reduce obesity,…”
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Bilirubin, a novel endocrine hormone with fat burning properties by Hinds, Terry D., Gordon, Darren M., Combs, Shauna D., Stec, David E.

“…Plasma bilirubin levels have been shown to be inversely related to obesity, diabetes, and cardiovascular events. Numerous clinical and population studies have…”
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Use of Multimodal Long-Wave Infrared Thermography Devices in Clinical Practice by Simman, Richard, Gordon, Darren M, Klomparens, Kara, Aviles, Jr, Frank

“…The current practice of assessing wounds is highly dependent on visual examination and clinical judgment; these methods are highly subjective and leave great…”
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Bilirubin Induces the Burning of Fat via the Nuclear Receptor PPARα by Gordon, Darren M., John, Kezia, Trabbic, Christopher J., Luniwal, Amarjit, Hankins, Michael W., Baum, Justin, Stec, David E., Hinds, Terry D.

“…Deposition fat in adipocytes has become key to understanding how obesity and insulin resistance impact morbidity and mortality. Several studies have shown a…”
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Use of Multimodal Long-Wave Infrared Thermography Devices in Clinical Practice by Simman, Richard, Gordon, Darren M, Klomparens, Kara, Aviles, Frank

“…BackgroundThe current practice of assessing wounds is highly dependent on visual examination and clinical judgment; these methods are highly subjective and…”
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