Search Results - "Gordon, Bradley S"

Regulation of muscle protein synthesis and the effects of catabolic states by Gordon, Bradley S., Kelleher, Andrew R., Kimball, Scot R.

“…Protein synthesis and degradation are dynamically regulated processes that act in concert to control the accretion or loss of muscle mass. The present article…”
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Hormonal regulation of core clock gene expression in skeletal muscle following acute aerobic exercise by Saracino, Patrick G., Rossetti, Michael L., Steiner, Jennifer L., Gordon, Bradley S.

“…Exercise increases skeletal muscle health in part by altering the types of genes that are transcribed. Previous work suggested that glucocorticoids signal…”
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Chronic Alcohol Consumption Disrupts the Skeletal Muscle Circadian Clock in Female Mice by Tice, Abigail L., Laudato, Joseph A., Gordon, Bradley S., Steiner, Jennifer L.

“…The intrinsic skeletal muscle core clock has emerged as a key feature of metabolic control and influences several aspects of muscle physiology. Acute alcohol…”
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Effects of alcohol on skeletal muscle contractile performance in male and female mice by Laudato, Joseph A, Tice, Abigail L, Call, Jarrod A, Gordon, Bradley S, Steiner, Jennifer L

“…Acute and chronic alcohol use can cause skeletal muscle myopathy in concert with impairments in skeletal muscle strength, function and fatigue resistance…”
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The duration of glucocorticoid treatment alters the anabolic response to high-force muscle contractions by Dunlap, Kirsten R, Steiner, Jennifer L, Hickner, Robert C, Chase, P Bryant, Gordon, Bradley S

“…Glucocorticoids induce a myopathy that includes loss of muscle mass and strength. Resistance exercise may reverse the muscle loss because it induces an…”
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Arrdc2 and Arrdc3 elicit divergent changes in gene expression in skeletal muscle following anabolic and catabolic stimuli by Gordon, Bradley S, Rossetti, Michael L, Eroshkin, Alexey M

“…Skeletal muscle is a highly plastic organ regulating various processes in the body. As such, loss of skeletal muscle underlies the increased morbidity and…”
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The role of androgens in the regulation of muscle oxidative capacity following aerobic exercise training by Rossetti, Michael L, Gordon, Bradley S

“…Reduced production or bioavailability of androgens, termed hypogonadism, occurs in a variety of pathological conditions. While androgens target numerous…”
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Emerging role for regulated in development and DNA damage 1 (REDD1) in the regulation of skeletal muscle metabolism by Gordon, Bradley S, Steiner, Jennifer L, Williamson, David L, Lang, Charles H, Kimball, Scot R

“…Since its discovery, the protein regulated in development and DNA damage 1 (REDD1) has been implicated in the cellular response to various stressors. Most…”
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REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise by Gordon, Bradley S, Steiner, Jennifer L, Rossetti, Michael L, Qiao, Shuxi, Ellisen, Leif W, Govindarajan, Subramaniam S, Eroshkin, Alexey M, Williamson, David L, Coen, Paul M

“…The metabolic stress placed on skeletal muscle by aerobic exercise promotes acute and long-term health benefits in part through changes in gene expression…”
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mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading by Martin, Tony D, Dennis, Michael D, Gordon, Bradley S, Kimball, Scot R, Jefferson, Leonard S

“…The present project was designed to investigate phosphorylation of p70S6K1 in an animal model of skeletal muscle overload. Within 24 h of male Sprague-Dawley…”
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Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction by Gordon, Bradley S, Steiner, Jennifer L, Lang, Charles H, Jefferson, Leonard S, Kimball, Scot R

“…Regulated in DNA damage and development 1 (REDD1) is a repressor of mTOR complex 1 (mTORC1) signaling. In humans, REDD1 mRNA expression in skeletal muscle is…”
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Loss of REDD1 augments the rate of the overload-induced increase in muscle mass by Gordon, Bradley S, Liu, Chang, Steiner, Jennifer L, Nader, Gustavo A, Jefferson, Leonard S, Kimball, Scot R

“…The overload-induced increase in muscle mass is accompanied by protein accretion; however, the initiating events are poorly understood. Regulated in…”
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Exercise increases utrophin protein expression in the mdx mouse model of Duchenne muscular dystrophy by Gordon, Bradley S., Lowe, Dawn A., Kostek, Matthew C.

“…ABSTRACT Introduction: Duchenne muscular dystrophy (DMD) is a lethal genetic disease caused by mutations in the dystrophin gene resulting in chronic muscle…”
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REDD1 deletion and treadmill running increase liver hepcidin and gluconeogenic enzymes in male mice by Barney, David E., Gordon, Bradley S., Hennigar, Stephen R.

“…The iron-regulatory hormone hepcidin is transcriptionally up-regulated by gluconeogenic signals. Recent evidence suggeststhat increases in circulating hepcidin…”
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Contractile regulation of the glucocorticoid-sensitive transcriptome in young and aged skeletal muscle by Laskin, Grant R, Waddell, David S, Vied, Cynthia, Gordon, Bradley S

“…Elevated glucocorticoids alter the skeletal muscle transcriptome to induce a myopathy characterized by muscle atrophy, muscle weakness, and decreased metabolic…”
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Androgen-mediated regulation of skeletal muscle protein balance by Rossetti, Michael L., Steiner, Jennifer L., Gordon, Bradley S.

“…Androgens significantly alter muscle mass in part by shifting protein balance in favor of net protein accretion. During various atrophic conditions, the…”
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Changes to the Skeletal Muscle Gene Expression Signature in Response to Nutrient and/or Mechanical Stimuli by Laskin, Grant S., Gordon, Bradley S.

“…Nutrient consumption and mechanical overload influence skeletal muscle metabolism and function. These metabolic and functional outcomes are mediated at least…”
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The influence of nutrients on mechanical overload-induced changes to skeletal muscle mRNA content by Laskin, Grant R., Gordon, Bradley S.

“…Mechanical overload and nutrients influence skeletal muscle phenotype, with the combination sometimes having a synergistic effect. Muscle phenotypes influenced…”
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SIRT1 induction in the skeletal muscle of male mice partially attenuates changes to whole-body metabolism in response to androgen deprivation by Laskin, Grant R., Steiner, Jennifer L., Berryman, Claire E., Gordon, Bradley S.

“…In males, androgens regulate whole body metabolism. The components in androgen target organs contributing to whole-body metabolic function remain ill defined…”
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Glucocorticoids differentially regulate the skeletal muscle transcriptome in response to acute aerobic exercise at distinct times of day by Dunlap, Kirsten, Laskin, Grant, Waddell, David, Black, Adam, Vied, Cynthia, Steiner, Jennifer, Gordon, Bradley S.

“…Adaptations to the skeletal muscle following long term aerobic exercise training are mediated at least in part by transcriptional changes that occur in…”
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