Search Results - "Gordge, P"

S‐nitrosothiols as selective antithrombotic agents – possible mechanisms by Gordge, MP, Xiao, F

“…S‐nitrosothiols have a number of potential clinical applications, among which their use as antithrombotic agents has been emphasized. This is largely because…”
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Protein disulfide-isomerase mediates delivery of nitric oxide redox derivatives into platelets by Bell, Susannah E, Shah, Chirag M, Gordge, Michael P

“…S-nitrosothiol compounds are important mediators of NO signalling and can give rise to various redox derivatives of NO: nitrosonium cation (NO+), nitroxyl…”
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Megakaryocyte apoptosis: sorting out the signals by Gordge, Michael P

“…British Journal of Pharmacology (2005) 145, 271–273. doi:10.1038/sj.bjp.0706202…”
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Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue by Gordge, P.C., Hulme, M.J., Clegg, R.A., Miller, W.R.

“…Because of their central role in the transduction of extracellular signals, protein kinases A (PKA) and C (PKC) are critical enzymes in the control of cellular…”
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Mitochondrial superoxide production during oxalate-mediated oxidative stress in renal epithelial cells by Khand, F.D., Gordge, M.P., Robertson, W.G., Noronha-Dutra, A.A., Hothersall, J.S.

“…Crystals of calcium oxalate monohydrate (COM) in the renal tubule form the basis of most kidney stones. Tubular dysfunction resulting from COM-cell…”
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Evidence for a cyclic GMP‐independent mechanism in the anti‐platelet action of S‐nitrosoglutathione by Gordge, M P, Hothersall, J S, Noronha‐Dutra, A A

“…We have measured the ability of a range of NO donor compounds to stimulate cyclic GMP accumulation and inhibit collagen‐induced aggregation of human washed…”
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Inhibition of neutrophil superoxide production by uremic concentrations of guanidino compounds by HIRAYAMA, A, NORONHA-DUTRA, A. A, GORDGE, M. P, NEILD, G. H, HOTHERSALL, J. S

“…In uremia, diminished reactive oxygen intermediate production is an important consequence of impaired neutrophil function. The effects of guanidino compounds,…”
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Cell surface thiol isomerases may explain the platelet-selective action of S-nitrosoglutathione by Xiao, Fang, Gordge, Michael P.

“…S-nitrosoglutathione (GSNO) at low concentration inhibits platelet aggregation without causing vasodilation, suggesting platelet-selective nitric oxide…”
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Role of a copper (I)‐dependent enzyme in the anti‐platelet action of S‐nitrosoglutathione by Gordge, M.P., Hothersall, J.S., Neild, G.H., Dutra, A.A. Noronha

“…1 S‐nitrosoglutathione (GSNO) is a potent and selective anti‐platelet agent, despite the fact that its spontaneous rate of release of nitric oxide (NO) is very…”
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Cell-mediated biotransformation of S-nitrosoglutathione by Gordge, Michael P., Addis, Paolo, Noronha-Dutra, Alberto A., Hothersall, John S.

“…Spontaneous release of nitric oxide (NO) from S-nitrosothiols cannot explain their bioactivity, suggesting a role for cellular metabolism or receptors. Using…”
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Highly elastomeric poly(3-hydroxyoctanoate) based natural polymer composite for enhanced keratinocyte regeneration by Rai, Ranjana, Roether, Judith A., Knowles, Jonathan C., Mordan, Nicola, Salih, Vehid, Locke, Ian C., Gordge, Michael P., McCormick, Aine, Mohn, Dirk, Stark, Wendelin J., Keshavarz, Tajalli, Boccaccini, Aldo R., Roy, Ipsita

“…A novel nanocomposite material combining the biocompatible, elastomeric, natural, biodegradable homopolymer poly(3-hydroxyoctanoate) (P(3HO)) with hemostatic…”
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Copper chelation‐induced reduction of the biological activity of S‐nitrosothiols by Gordge, M.P., Meyer, D.J., Hothersall, J., Neild, G.H., Payne, N.N., Noronha‐Dutra, A.

“…1 The effect of copper on the activity of the S‐nitrosothiol compounds S‐nitrosocysteine (cysNO) and S‐nitrosoglutathione (GSNO) was investigated, using the…”
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Nitric oxide: a one‐trick pony? by GORDGE, M. P.

“…See also Dangel O, Mergia E, Karlisch K, Groneberg D, Koesling D, Friebe A. Nitric oxide‐sensitive guanylyl cyclase is the only nitric oxide receptor mediating…”
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Inhibition of thiol isomerase activity diminishes endothelial activation of plasminogen, but not of protein C by Smith, C.L, Shah, C.M, Kamaludin, N, Gordge, M.P

“…Abstract Introduction Cell surface thiol isomerase enzymes, principally protein disulphide isomerase (PDI), have emerged as important regulators of platelet…”
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Uremic concentrations of guanidino compounds inhibit neutrophil superoxide production by Hirayama, Aki, Noronha-Dutra, Alberto A., Gordge, Michael P., Neild, Guy H., Hothersall, John S.

“…Uremic concentrations of guanidino compounds inhibit neutrophil superoxide production. In Uremia, diminished reactive oxygen intermediate (ROI) production is…”
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Rapid S-nitrosothiol metabolism by platelets and megakaryocytes by Shah, C M, Locke, I C, Chowdrey, H S, Gordge, M P

“…RSNOs (S-nitrosothiols) regulate platelet and megakaryocyte function, and may act in vivo as a nitric oxide reservoir. There is a discrepancy between the…”
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How cytotoxic is nitric oxide? by Gordge, M P

“…Nitric oxide (NO) shows an unusual divergence of action, being utilised both as a physiological signalling molecule, and as a toxic mediator. NO-mediated…”
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Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery by Shah, C.M., Bell, S.E., Locke, I.C., Chowdrey, H.S., Gordge, M.P.

“…In this study, we investigated the role of protein disulphide isomerase (PDI) in rapid metabolism of S-nitrosoglutathione (GSNO) and S-nitrosoalbumin (albSNO)…”
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Inhibitors of protein kinase C by Gordge, P C, Ryves, W J

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Inhibition of transforming growth factor α (TGF-α)-mediated growth effects in ovarian cancer cell lines by a tyrosine kinase inhibitor ZM 252868 by SIMPSON, B. J. B, BARTLETT, J. M. S, LANGDON, S. P, MACLEOD, K. G, RABIASZ, G, MILLER, E. P, RAE, A. L, GORDGE, P, LEAKE, R. E, MILLER, W. R, SMYTH, J

“…The modulating effects of the epidermal growth factor (EGF) receptor-specific tyrosine kinase inhibitor ZM 252868 on cell growth and signalling have been…”
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