The new antitumor agent morfozol: Intracellular distribution and effects on DNA synthesis

The new antitumor agent morfozol: Intracellular distribution and effects on DNA synthesis

In vitro studies of the interaction of DNA with morfozol (a palladium (II) acid complex) demonstrated active binding with DNA, detected in terms of reductions in accessibility to actinomycin D. Extensive and stable inhibition of DNA synthesis was seen in L1210 and P388 leukemia cells; this was less...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical chemistry journal Vol. 42; no. 2; pp. 53 - 55
Main Authors: Gorbacheva, P. B., Tikhomirov, A. G., Dederer, L. Yu, Ivanova, N. A., Erofeeva, O. S., Ochertyanova, L. I., Efimenko, I. A.
Format: Journal Article
Language:English
Published: Boston Springer US 01-02-2008
Subjects:
Antitumor agents
Cytosol
Dactinomycin
DNA biosynthesis
DNA-directed DNA polymerase
Leukemia
Medicine
Melanoma
Molecular-Biological Questions in the Creation of Therapeutic Agents and Studies of their Mechanisms of Action
Organic Chemistry
palladium
Pharmacology/Toxicology
Pharmacy
regulatory proteins
Tumors
Actinomycin
Nuclear Fraction
Platinum Compound
Intracellular Distribution
Palladium
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In vitro studies of the interaction of DNA with morfozol (a palladium (II) acid complex) demonstrated active binding with DNA, detected in terms of reductions in accessibility to actinomycin D. Extensive and stable inhibition of DNA synthesis was seen in L1210 and P388 leukemia cells; this was less marked in Akatol and B16 melanoma cells. Studies of the intracellular distribution of palladium in Akatol and P388 tumors after administration of Morfozol to tumor-bearing mice showed predominant accumulation in the cytosol fraction, which is evidence of an active interaction of the agent with cell proteins. I.p. administration of morfozol led to quite high palladium concentrations in the nuclear fraction. As morfozol is characterized by high reactivity, there are probably other targets, such as DNA polymerase and regulatory protein factors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-008-0058-1