Search Results - "Gopalkrishnashetty Sreenivasmurthy, Sravan"

A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro by Wang, Ziying, Yang, Chuanbin, Liu, Jia, Chun-Kit Tong, Benjamin, Zhu, Zhou, Malampati, Sandeep, Gopalkrishnashetty Sreenivasmurthy, Sravan, Cheung, King-Ho, Iyaswamy, Ashok, Su, Chengfu, Lu, Jiahong, Song, Juxian, Li, Min

“…bstract TFEB (transcription factor EB), which is a master regulator of autophagy and lysosome biogenesis, is considered to be a new therapeutic target for…”
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Targeting Aggrephagy for the Treatment of Alzheimer's Disease by Malampati, Sandeep, Song, Ju-Xian, Chun-Kit Tong, Benjamin, Nalluri, Anusha, Yang, Chuan-Bin, Wang, Ziying, Gopalkrishnashetty Sreenivasmurthy, Sravan, Zhu, Zhou, Liu, Jia, Su, Chengfu, Krishnamoorthi, Senthilkumar, Iyaswamy, Ashok, Cheung, King-Ho, Lu, Jia-Hong, Li, And Min

“…Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a…”
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Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease by Zhu, Zhou, Yang, Chuanbin, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Sreenivasmurthy, Sravan Gopalkrishnashetty, Liu, Jia, Wang, Ziying, Tong, Benjamin Chun-Kit, Song, Juxian, Lu, Jiahong, Cheung, King-Ho, Li, Min

“…The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a…”
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A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer's disease models by Song, Ju‐Xian, Malampati, Sandeep, Zeng, Yu, Durairajan, Siva Sundara Kumar, Yang, Chuan‐Bin, Tong, Benjamin Chun‐Kit, Iyaswamy, Ashok, Shang, Wen‐Bin, Sreenivasmurthy, Sravan Gopalkrishnashetty, Zhu, Zhou, Cheung, King‐Ho, Lu, Jia‐Hong, Tang, Chunzhi, Xu, Nenggui, Li, Min

“…Accumulating studies have suggested that targeting transcription factor EB (TFEB), an essential regulator of autophagy‐lysosomal pathway (ALP), is promising…”
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Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review by Wang, Zi-Ying, Liu, Jia, Zhu, Zhou, Su, Cheng-Fu, Sreenivasmurthy, Sravan Gopalkrishnashetty, Iyaswamy, Ashok, Lu, Jia-Hong, Chen, Gang, Song, Ju-Xian, Li, Min

“…[Display omitted] •Traditional Chinese Medicine (TCM) is important source for modern drug development.•The important role of autophagy in neurodegenerative…”
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Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer's Disease by Guan, Xinjie, Iyaswamy, Ashok, Sreenivasmurthy, Sravan Gopalkrishnashetty, Su, Chengfu, Zhu, Zhou, Liu, Jia, Kan, Yuxuan, Cheung, King-Ho, Lu, Jiahong, Tan, Jieqiong, Li, Min

“…Eukaryotic cells possess a plethora of regulatory mechanisms to maintain homeostasis and ensure proper biochemical functionality. Autophagy, a central,…”
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Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies by Tong, Benjamin Chun-Kit, Huang, Alexis Shiying, Wu, Aston Jiaxi, Iyaswamy, Ashok, Ho, Olivia Ka-Yi, Kong, Anna Hau-Yee, Sreenivasmurthy, Sravan Gopalkrishnashetty, Zhu, Zhou, Su, Chengfu, Liu, Jia, Song, Juxian, Li, Min, Cheung, King-Ho

“…Abstract Background Tauopathies are neurodegenerative diseases that are associated with the pathological accumulation of tau-containing tangles in the brain…”
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TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2 by Yang, Chuan-bin, Liu, Jia, Tong, Benjamin Chun-Kit, Wang, Zi-ying, Zhu, Zhou, Su, Cheng-fu, Sreenivasmurthy, Sravan Gopalkrishnashetty, Wu, Jia-xi, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Huang, Shi-ying, Cheung, King-ho, Song, Ju-xian, Tan, Jie-qiong, Lu, Jia-hong, Li, Min

“…Transcriptional factor EB (TFEB), a master regulator of autophagy and lysosomal biogenesis, is generally regarded as a pro-survival factor. Here, we identify…”
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Corrigendum to “Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review” [ Biomed. Pharamacother. 133, (2021) 110968] by Wang, Zi-Ying, Liu, Jia, Zhu, Zhou, Su, Cheng-Fu, Sreenivasmurthy, Sravan Gopalkrishnashetty, Iyaswamy, Ashok, Lu, Jia-Hong, Chen, Gang, Song, Ju-Xian, Li, Min

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A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38 by Yang, Chuanbin, Zhu, Zhou, Tong, Benjamin Chun-Kit, Iyaswamy, Ashok, Xie, Wen-Jian, Zhu, Yu, Sreenivasmurthy, Sravan Gopalkrishnashetty, Senthilkumar, Krishnamoorthi, Cheung, King-Ho, Song, Ju-Xian, Zhang, Hong-Jie, Li, Min

“…TFEB (transcription factor EB) and TFE3 (transcription factor E3) are “master regulators” of autophagy and lysosomal biogenesis. The stress response p38…”
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Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells by Hindupur, Sravanth K, Balaji, Sai A, Saxena, Meera, Pandey, Shubham, Sravan, Gopalkrishnashetty Sreenivasmurthy, Heda, Namrata, Kumar, M Vijaya, Mukherjee, Geetashree, Dey, Devaveena, Rangarajan, Annapoorni

“…Matrix detachment triggers anoikis, a form of apoptosis, in most normal epithelial cells, while acquisition of anoikis resistance is a prime requisite for…”
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Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models by Selvarasu, Karthikeyan, Singh, Abhay Kumar, Iyaswamy, Ashok, Gopalkrishnashetty Sreenivasmurthy, Sravan, Krishnamoorthi, Senthilkumar, Bera, Amal Kanti, Huang, Jian-Dong, Durairajan, Siva Sundara Kumar

“…Many neurodegenerative diseases, such as Alzheimer’s disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17, are characterized by…”
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Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer’s disease therapy by Sreenivasmurthy, Sravan Gopalkrishnashetty, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Reddi, Rambabu N., Kammala, Ananth Kumar, Vasudevan, Karthick, Senapati, Sanjib, Zhu, Zhou, Su, Cheng-Fu, Liu, Jia, Guan, Xin-Jie, Chua, Ka-Kit, Cheung, King-Ho, Chen, Hubiao, Zhang, Hong-Jie, Zhang, Yuan, Song, Ju-Xian, Kumar Durairajan, Siva Sundara, Li, Min

“…Emerging evidence from Alzheimer’s disease (AD) patients suggests that reducing tau pathology can restore cognitive and memory loss. To reduce tau pathology,…”
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Interaction of Tau with Kinesin-1: Effect of Kinesin-1 Heavy Chain Elimination on Autophagy-Mediated Mutant Tau Degradation by Selvarasu, Karthikeyan, Singh, Abhay Kumar, Dakshinamoorthy, Avinash, Sreenivasmurthy, Sravan Gopalkrishnashetty, Iyaswamy, Ashok, Radhakrishnan, Moorthi, Patnaik, Supriti, Huang, Jian-Dong, Williams, Leonard L, Senapati, Sanjib, Durairajan, Siva Sundara Kumar

“…Natively unfolded tau has a low propensity to form aggregates, but in tauopathies, such as Alzheimer's disease (AD), tau aggregates into paired helical…”
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Real-Time Detection and Visualization of Amyloid‑β Aggregates Induced by Hydrogen Peroxide in Cell and Mouse Models of Alzheimer’s Disease by Wang, Xueli, Iyaswamy, Ashok, Xu, Di, Krishnamoorthi, Senthilkumar, Sreenivasmurthy, Sravan Gopalkrishnashetty, Yang, Yuncong, Li, Yinhui, Chen, Chen, Li, Min, Li, Hung-Wing, Wong, Man Shing

“…Oxidative stress, caused by an imbalance between the production and the accumulation of reactive oxygen species (ROS), is a prominent cause of the…”
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Study of BDE-47 induced Parkinson’s disease-like metabolic changes in C57BL/6 mice by integrated metabolomic, lipidomic and proteomic analysis by Ji, Fenfen, Sreenivasmurthy, Sravan Gopalkrishnashetty, Wei, Juntong, Shao, Xiaojian, Luan, Hemi, Zhu, Lin, Song, Juxian, Liu, Liangfeng, Li, Min, Cai, Zongwei

“…[Display omitted] •Omics study of BDE-47 induced metabolic changes in mice brain.•BDE-47 can disturb neurotransmitter production, endocytosis and…”
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A Self-Assembled α‑Synuclein Nanoscavenger for Parkinson’s Disease by Liu, Jingyi, Liu, Chao, Zhang, Jinfeng, Zhang, Yunming, Liu, Keyin, Song, Ju-Xian, Sreenivasmurthy, Sravan Gopalkrishnashetty, Wang, Ziying, Shi, Yesi, Chu, Chengchao, Zhang, Yang, Wu, Caisheng, Deng, Xianhua, Liu, Xingyang, Song, Jing, Zhuang, Rongqiang, Huang, Shuqiong, Zhang, Pengfei, Li, Min, Wen, Lei, Zhang, Yun wu, Liu, Gang

“…Although emerging evidence suggests that the pathogenesis of Parkinson’s disease (PD) is closely related to the aggregation of alpha-synuclein (α-syn) in the…”
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Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease by Chakraborty, Anirban, Sreenivasmurthy, Sravan Gopalkrishnashetty, Miller, Wyatt, Huai, Weihan, Biswas, Tapan, Mandal, Santi Mohan, Boscá, Lisardo, Krishnan, Balaji, Ghosh, Gourisankar, Hazra, Tapas

“…Huntington's disease (HD) and spinocerebellar ataxia type 3 (SCA3) are the two most prevalent polyglutamine (polyQ) neurodegenerative diseases, caused by CAG…”
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Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease by Tong, Benjamin Chun-Kit, Wu, Aston Jiaxi, Huang, Alexis Shiying, Dong, Rui, Malampati, Sandeep, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Sreenivasmurthy, Sravan Gopalkrishnashetty, Zhu, Zhou, Su, Chengfu, Liu, Jia, Song, Juxian, Lu, Jia-Hong, Tan, Jieqiong, Pan, Weidong, Li, Min, Cheung, King-Ho

“…Impairment of the macroautophagy/autophagy-lysosomal pathway (ALP) can lead to amyloid plaque accumulation in Alzheimer disease (AD); however, the underlying…”
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Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition by Sreenivasmurthy, Sravan Gopalkrishnashetty, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Senapati, Sanjib, Malampati, Sandeep, Zhu, Zhou, Su, Cheng-Fu, Liu, Jia, Guan, Xin-Jie, Tong, Benjamin Chun-Kit, Cheung, King-Ho, Tan, Jie-Qiong, Lu, Jia-Hong, Durairajan, Siva Sundara Kumar, Song, Ju-Xian, Li, Min

“…•The natural alkaloid protopine is brain-permeable, which improves memory functions in 3xTg-AD and P301S tau transgenic models of AD.•Protopine specifically…”
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