Search Results - "Gopalasingam, Nigopan"

Lactate infusion elevates cardiac output through increased heart rate and decreased vascular resistance: a randomised, blinded, crossover trial in a healthy porcine model by Hørsdal, Oskar Kjærgaard, Moeslund, Niels, Berg-Hansen, Kristoffer, Nielsen, Roni, Møller, Niels, Eiskjær, Hans, Wiggers, Henrik, Gopalasingam, Nigopan

“…Lactate is traditionally recognized as a by-product of anaerobic metabolism. However, lactate is a preferred oxidative substrate for stressed myocardium…”
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Stimulation of the Hydroxycarboxylic Acid Receptor 2 With the Ketone Body 3-Hydroxybutyrate and Niacin in Patients With Chronic Heart Failure: Hemodynamic and Metabolic Effects by Gopalasingam, Nigopan, Christensen, Kristian Hylleberg, Berg Hansen, Kristoffer, Nielsen, Roni, Johannsen, Mogens, Gormsen, Lars Christian, Boedtkjer, Ebbe, Nørregaard, Rikke, Møller, Niels, Wiggers, Henrik

“…Background The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output (CO) in patients with heart failure through unknown mechanisms. 3-OHB activates…”
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Hemodynamic Effects of Ketone Bodies in Patients With Pulmonary Hypertension by Nielsen, Roni, Christensen, Kristian Hylleberg, Gopalasingam, Nigopan, Berg-Hansen, Kristoffer, Seefeldt, Jacob, Homilius, Casper, Boedtkjer, Ebbe, Andersen, Mads Jønsson, Wiggers, Henrik, Møller, Niels, Bøtker, Hans Erik, Mellemkjær, Søren

“…Background Pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) are debilitating diseases with a high mortality…”
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Three Weeks on a Ketogenic Diet Reduces Free Testosterone and Free Estradiol in Middle-Aged Obese Men and Women by Svart, Mads, Rittig, Nikolaj, Luong, Thien Vinh, Gopalasingam, Nigopan, Vestergaard, Esben Thyssen, Gormsen, Lars, Søndergaard, Esben, Thomsen, Henrik Holm, Gravholt, Claus H

“…Beta-hydroxybuturate ( -OHB) supplements are commonly utilized in sports by both recreational and professional athletes. In a recent study, we observed a drop…”
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Enantiomer-Specific Cardiovascular Effects of the Ketone Body 3-Hydroxybutyrate by Gopalasingam, Nigopan, Moeslund, Niels, Christensen, Kristian Hylleberg, Berg-Hansen, Kristoffer, Seefeldt, Jacob, Homilius, Casper, Nielsen, Erik Nguyen, Dollerup, Mie Ringgaard, Alstrup Olsen, Aage K, Johannsen, Mogens, Boedtkjer, Ebbe, Møller, Niels, Eiskjær, Hans, Gormsen, Lars Christian, Nielsen, Roni, Wiggers, Henrik

“…The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output (CO) by 35% to 40% in healthy people and people with heart failure. The mechanisms…”
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CARDIAC EFFECTS OF KETONE ESTER IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION: A RANDOMIZED, CONTROLLED, DOUBLE-BLIND TRIAL by Berg-Hansen, Kristoffer, Gopalasingam, Nigopan, Christensen, Kristian Hylleberg, Ladefoged, Bertil, Nielsen, Roni R., M⊘ller, Niels, wiggers, henrik

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INCREASING LEVELS OF POSITIVE END-EXPIRATORY PRESSURE REDUCES MYOCARDIAL OXYGEN CONSUMPTION IN A PORCINE MODEL OF CARDIOGENIC SHOCK by Horsdal, Oskar, Gopalasingam, Nigopan, Lyhne, Mads Dam, Ellegaard, Mark, Wethelund, Kasper, wiggers, henrik, Christensen, Steffen, Berg-Hansen, Kristoffer

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TWO-WEEK KETONE ESTER TREATMENT IN PATIENTS WITH TYPE 2 DIABETES AND HEART FAILURE WITH PRESERVED EJECTION FRACTION: EFFECTS ON RESTING AND EXERCISE HEMODYNAMICS by Gopalasingam, Nigopan, Berg-Hansen, Kristoffer, Christensen, Kristian Hylleberg, Ladefoged, Bertil, Nielsen, Roni R., M⊘ller, Niels, wiggers, henrik

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Cardiovascular Effects of Increasing Positive End-Expiratory Pressure in A Model of Left Ventricular Cardiogenic Shock in Female Pigs by Hørsdal, Oskar Kjærgaard, Wethelund, Kasper Lykke, Gopalasingam, Nigopan, Lyhne, Mads Dam, Ellegaard, Mark Stoltenberg, Møller-Helgestad, Ole Kristian, Ravn, Hanne Berg, Wiggers, Henrik, Christensen, Steffen, Berg-Hansen, Kristoffer

“…Cardiogenic shock (CS) presents a medical challenge with limited treatment options. Positive end-expiratory pressure (PEEP) during mechanical ventilation has…”
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Abstract 15256: Treatment With Ketone Ester in Patients With Cardiogenic Shock Improves Cardiac Performance by Berg Hansen, Kristoffer, Christensen, Kristian Hylleberg, Gopalasingam, Nigopan, Nielsen, Roni, Møller, Niels, Birkelund, Thomas, christensen, steffen, Wiggers, Henrik

“…IntroductionCardiogenic shock is a life-threatening condition but no medical therapy has been documented to improve outcome. Recent evidence suggests that the…”
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Cardiovascular Effects of Oral Ketone Ester Treatment in Patients With Heart Failure With Reduced Ejection Fraction: A Randomized, Controlled, Double-Blind Trial by Berg-Hansen, Kristoffer, Gopalasingam, Nigopan, Christensen, Kristian Hylleberg, Ladefoged, Bertil, Andersen, Mads Jønsson, Poulsen, Steen Hvitfeldt, Borlaug, Barry A, Nielsen, Roni, Møller, Niels, Wiggers, Henrik

“…Heart failure triggers a shift in myocardial metabolic substrate utilization, favoring the ketone body 3-hydroxybutyrate as energy source. We hypothesized that…”
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Beneficial Effects of Ketone Ester in Patients With Cardiogenic Shock: A Randomized, Controlled, Double-Blind Trial by Berg-Hansen, Kristoffer, Christensen, Kristian Hylleberg, Gopalasingam, Nigopan, Nielsen, Roni, Eiskjær, Hans, Møller, Niels, Birkelund, Thomas, Christensen, Steffen, Wiggers, Henrik

“…Cardiogenic shock (CS) is a life-threatening condition with sparse treatment options. The ketone body 3-hydroxybutyrate has favorable hemodynamic effects in…”
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Randomized Crossover Trial of 2-Week Ketone Ester Treatment in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction by Gopalasingam, Nigopan, Berg-Hansen, Kristoffer, Christensen, Kristian Hylleberg, Ladefoged, Bertil T, Poulsen, Steen Hvitfeldt, Andersen, Mads Jønsson, Borlaug, Barry, Nielsen, Roni, Møller, Niels, Wiggers, Henrik

“…Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality in patients with type 2 diabetes (T2DM). Acute increases in…”
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Effects of exogenous lactate on lipid, protein, and glucose metabolism-a randomized crossover trial in healthy males by Pedersen, Mette G B, Rittig, Nikolaj, Bangshaab, Maj, Berg-Hansen, Kristoffer, Gopalasingam, Nigopan, Gormsen, Lars C, Søndergaard, Esben, Møller, Niels

“…Lactate may inhibit lipolysis and thus enhance insulin sensitivity, but there is a lack of metabolic human studies. This study aimed to determine how…”
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Posterior wall puncture during ultrasound-guided arterial cannulation suggests inadequate operator skills by Gopalasingam, Nigopan, Juhl-Olsen, Peter, Sloth, Erik

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Beneficial Effects of Ketone Ester in Patients With Cardiogenic Shock by Berg-Hansen, Kristoffer, Christensen, Kristian Hylleberg, Gopalasingam, Nigopan, Nielsen, Roni, Eiskjær, Hans, Møller, Niels, Birkelund, Thomas, Christensen, Steffen, Wiggers, Henrik

“…Cardiogenic shock (CS) is a life-threatening condition with sparse treatment options. The ketone body 3-hydroxybutyrate has favorable hemodynamic effects in…”
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Myocardial work across different etiologies of right ventricular dysfunction and healthy controls by Berg-Hansen, Kristoffer, Gopalasingam, Nigopan, Clemmensen, Tor Skibsted, Andersen, Mads Jønsson, Mellemkjaer, Søren, Poulsen, Steen Hvitfeldt, Jensen, Jesper Khedri, Nielsen, Roni

“…Evaluating right ventricular (RV) function remains a challenge. Recently, novel echocardiographic assessment of RV myocardial work (RVMW) by non-invasive…”
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Ultrasound-guided radial artery catheterisation increases the success rate among anaesthesiology residents: a randomised study by Gopalasingam, Nigopan, Hansen, Marlene A, Thorn, Sofie, Sloth, Erik, Juhl-Olsen, Peter

“…The palpation technique is generally used for radial artery catheterisation, but is associated with a high rate of failure and complications. Dynamic needle…”
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A successful model to learn and implement ultrasound‐guided venous catheterization in apheresis by Gopalasingam, Nigopan, Thomsen, Anna‐Marie Eller, Folkersen, Lars, Juhl‐Olsen, Peter, Sloth, Erik

“…Background Apheresis treatments can be performed with peripheral venous catheters (PVC), although central venous catheters (CVC) are inserted when PVCs fail or…”
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Dynamic needle tip positioning-para vessel approach by Sloth, Erik, Gopalasingam, Nigopan, Obad, Damir S., Kristensen, Bo S., Juhl-Olsen, Peter

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