Cadmium and Chlorpyrifos Induced Lipid Peroxidation in Brain, Liver and Kidney of Wistar Rats
The work was designed with 4 groups for 28 days. 1: Control. 2: CdCl2 @ 22.5mg/ kg b.wt / oral. 3: CPF @ 25 mg/ kg b.wt /per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/ kg b.wt /per oral. Higher mean values of liver, kidney and brain TBARS were observed in G-2, 3 and 4 on 15th and 29th day. Liver section...
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| Published in: | Toxicology international pp. 475 - 480 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
07-02-2023
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| Online Access: | Get full text |
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| Summary: | The work was designed with 4 groups for 28 days. 1: Control. 2: CdCl2 @ 22.5mg/ kg b.wt / oral. 3: CPF @ 25 mg/ kg b.wt /per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/ kg b.wt /per oral. Higher mean values of liver, kidney and brain TBARS were observed in G-2, 3 and 4 on 15th and 29th day. Liver section in group 2 revealed mild degenerative changes in group 3; in group 4 mild to moderate peri portal fibrosis. Kidney section in group 2 showed shrunken glomeruli, necrosis; kidney section showed degeneration and necrosis of tubular epithelium with casts in the lumen in group 3 and necrosis with casts in the lumen in group 4. Brain section in group 2 showed mild perivascular cuffing, mild to moderate degeneration of Purkinji cells in group 3 and in group 4 degeneration of Purkinje cells. Effects in G-4 were severe than individual groups due to synergistic action of the combined pollutants than the individual effects. |
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| ISSN: | 0971-6580 0976-5131 |
| DOI: | 10.18311/ti/2022/v29i4/30251 |