Search Results - "Gopal, Udhayakumar"

Cell surface GRP78: a potential mechanism of therapeutic resistant tumors by Amaresan, Rajalakshmi, Gopal, Udhayakumar

“…GRP78 is a protein that acts as a chaperone within the endoplasmic reticulum (ER) and has multiple functions. It is induced by stress and abets cells from…”
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Cell surface GRP78 signaling: An emerging role as a transcriptional modulator in cancer by Gopal, Udhayakumar, Pizzo, Salvatore V.

“…Cancer cells acquire dysregulated gene expression to establish specific transcriptional dependencies and their underlying mechanisms that are ultimately…”
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Glucose‐regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders by Gonzalez‐Gronow, Mario, Gopal, Udhayakumar, Austin, Richard C., Pizzo, Salvatore V.

“…The 78 kDa glucose‐regulated protein (GRP78) is an endoplasmic reticulum (ER)‐resident molecular chaperone. GRP78 is a member of the 70 kDa heat shock family…”
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Activated α2-Macroglobulin Regulates Transcriptional Activation of c-MYC Target Genes through Cell Surface GRP78 Protein by Gopal, Udhayakumar, Gonzalez-Gronow, Mario, Pizzo, Salvatore Vincent

“…Activated α2-macroglobulin (α2M*) signals predominantly through cell surface GRP78 (CS-GRP78) to promote proliferation and survival of cancer cells; however,…”
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Secreted Hsp90 Is a Novel Regulator of the Epithelial to Mesenchymal Transition (EMT) in Prostate Cancer by Hance, Michael W., Dole, Krystal, Gopal, Udhayakumar, Bohonowych, Jessica E., Jezierska-Drutel, Agnieszka, Neumann, Carola A., Liu, Haibo, Garraway, Isla P., Isaacs, Jennifer S.

“…Prostate cancer (PCa) is the most frequently diagnosed malignancy in men, and the second highest contributor of male cancer related lethality. Disease…”
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A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion by Gopal, Udhayakumar, Bohonowych, Jessica E, Lema-Tome, Carla, Liu, Angen, Garrett-Mayer, Elizabeth, Wang, Bingcheng, Isaacs, Jennifer S

“…Extracellular Hsp90 protein (eHsp90) potentiates cancer cell motility and invasion through a poorly understood mechanism involving ligand mediated function…”
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Cell surface GRP78 promotes tumor cell histone acetylation through metabolic reprogramming: a mechanism which modulates the Warburg effect by Gopal, Udhayakumar, Pizzo, Salvatore V.

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Shigella dysenteriae modulates BMP pathway to induce mucin gene expression in vivo and in vitro by Gopal, Ashidha, Iyer, Soumya Chidambaram, Gopal, Udhayakumar, Devaraj, Niranjali, Halagowder, Devaraj

“…Mucosal epithelial cells in the intestine act as the first line of host defense against pathogens by increasing mucin production for clearance. Despite this…”
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Hsp90 Is an Essential Regulator of EphA2 Receptor Stability and Signaling: Implications for Cancer Cell Migration and Metastasis by Annamalai, Balasubramaniam, Liu, Xueguang, Gopal, Udhayakumar, Isaacs, Jennifer S

“…A subset of Eph receptors and their corresponding ligands are commonly expressed in tumor cells where they mediate biological processes such as cell migration…”
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Development of a Triple-Negative Breast Cancer Leptomeningeal Disease Model in Zebrafish by Gopal, Udhayakumar, Monroe, Jerry D, Marudamuthu, Amarnath S, Begum, Salma, Walters, Bradley J, Stewart, Rodney A, Washington, Chad W, Gibert, Yann, Zachariah, Marcus A

“…Leptomeningeal disease occurs when cancer cells migrate into the ventricles of the brain and spinal cord and then colonize the meninges of the central nervous…”
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Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation by Bohonowych, Jessica E S, Peng, Shuping, Gopal, Udhayakumar, Hance, Michael W, Wing, Shane B, Argraves, Kelley M, Lundgren, Karen, Isaacs, Jennifer S

“…Perturbing Hsp90 chaperone function targets hypoxia inducible factor (HIF) function in a von Hippel-Lindau (VHL) independent manner, and represents an approach…”
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Targeting cell surface GRP78 enhances pancreatic cancer radiosensitivity through YAP/TAZ protein signaling by Gopal, Udhayakumar, Mowery, Yvonne, Young, Kenneth, Pizzo, Salvatore Vincent

“…Ionizing radiation (IR) can promote migration and invasion of cancer cells, but the basis for this phenomenon has not been fully elucidated. IR increases…”
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Molecular and functional crosstalk between extracellular Hsp90 and ephrin A1 signaling by Daoud, Abdelkader, Gopal, Udhayakumar, Kaur, Jasmine, Isaacs, Jennifer S

“…The Eph receptor tyrosine kinase family member EphA2 plays a pivotal role in modulating cytoskeletal dynamics to control cancer cell motility and invasion…”
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Cell surface GRP78 promotes tumor cell histone acetylation through metabolic reprogramming: a mechanism which modulates the Warburg effect by Gopal, Udhayakumar, Pizzo, Salvatore V

“…Acetyl coenzyme A (acetyl-CoA) is essential for histone acetylation, to promote cell proliferation by regulating gene expression. However, the underlying…”
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Interaction of MUC1 with β-catenin modulates the Wnt target Gene cyclinD1 in H. pylori-induced gastric cancer by Udhayakumar, Gopal, Jayanthi, Venkatraman, Devaraj, Niranjali, Devaraj, Halagowder

“…β‐catenin can function as an oncogene when it is translocated to the nucleus, binds to T‐cell factor (TCF) or lymphoid enhance factor and transactivate its…”
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Nuclear translocation of β-catenin correlates with CD44 upregulation in Helicobacter pylori-infected gastric carcinoma by Udhayakumar, Gopal, Jayanthi, Venkatraman, Devaraj, Niranjali, Devaraj, Halagowder

“…Infection with Helicobacter pylori CagA -positive strains is associated with gastric adenocarcinoma. CagA H. pylori activates the β-catenin signal by…”
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Abstract 348: Extracellular heat shock protein 90 (eHsp90) initiates EMT events and enhances cell motility in prostate cancer by Hance, Michael W., Gopal, Udhayakumar, Bohonowych, Jessica, Isaacs, Jennifer S.

“…Abstract Prostate Cancer (PCa) is the most commonly diagnosed malignancy in men, responsible for the second highest lethality. Although early cancer detection…”
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Abstract 434: A novel extracellular chaperokine function of Hsp90 is essential for EphA2-driven cell migration in glioblastoma by Gopal, Udhayakumar, Wang, Bingcheng, Isaacs, Jennifer S.

“…Abstract Glioblastoma multiforme (GBM) is among the most common and aggressive brain tumors with a strong propensity to invade and migrate into surrounding…”
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Nuclear translocation of [beta]-catenin correlates with CD44 upregulation in Helicobacter pylori-infected gastric carcinoma by Udhayakumar, Gopal, Jayanthi, Venkatraman, Devaraj, Niranjali, Devaraj, Halagowder

“…Infection with Helicobacter pylori CagA-positive strains is associated with gastric adenocarcinoma. CagA H. pylori activates the [beta]-catenin signal by…”
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Helicobacter pylori detection and genotyping in gastric biopsy specimens from Chennai patients (India) by Udhayakumar, Gopal, Senthilkumar, Cinghu, Jayanthi, Venkatraman, Devaraj, Niranjali, Devaraj, Halagowder

“…The aim of the present study was to investigate the prevalence of Helicobacter pylori infection and the correlation between cagA and vacA (mid-region)…”
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