Search Results - "Gopal, Suhasini R"

Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III by Geng, Ruishuang, Omar, Akil, Gopal, Suhasini R., Chen, Daniel H.-C., Stepanyan, Ruben, Basch, Martin L., Dinculescu, Astra, Furness, David N., Saperstein, David, Hauswirth, William, Lustig, Lawrence R., Alagramam, Kumar N.

“…Usher syndrome type III (USH3) characterized by progressive loss of vision and hearing is caused by mutations in the clarin-1 gene ( CLRN1 ). Clrn1 knockout…”
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Clarin‐2 is essential for hearing by maintaining stereocilia integrity and function by Dunbar, Lucy A, Patni, Pranav, Aguilar, Carlos, Mburu, Philomena, Corns, Laura, Wells, Helena RR, Delmaghani, Sedigheh, Parker, Andrew, Johnson, Stuart, Williams, Debbie, Esapa, Christopher T, Simon, Michelle M, Chessum, Lauren, Newton, Sherylanne, Dorning, Joanne, Jeyarajan, Prashanthini, Morse, Susan, Lelli, Andrea, Codner, Gemma F, Peineau, Thibault, Gopal, Suhasini R, Alagramam, Kumar N, Hertzano, Ronna, Dulon, Didier, Wells, Sara, Williams, Frances M, Petit, Christine, Dawson, Sally J, Brown, Steve DM, Marcotti, Walter, El‐Amraoui, Aziz, Bowl, Michael R

“…Hearing relies on mechanically gated ion channels present in the actin‐rich stereocilia bundles at the apical surface of cochlear hair cells. Our knowledge of…”
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Inhibition of Mitochondrial Division Attenuates Cisplatin-Induced Toxicity in the Neuromast Hair Cells by Vargo, Jonathon W, Walker, Steven N, Gopal, Suhasini R, Deshmukh, Aditi R, McDermott, Jr, Brian M, Alagramam, Kumar N, Stepanyan, Ruben

“…Cisplatin and other related platinum antineoplastic drugs are commonly used in the treatment of a variety of cancers in both adults and children but are often…”
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Unconventional secretory pathway activation restores hair cell mechanotransduction in an USH3A model by Gopal, Suhasini R., Lee, Yvonne T., Stepanyan, Ruben, McDermott, Brian M., Alagramam, Kumar N.

“…The pathogenic variant c.144T>G (p.N48K) in the clarin1 gene (CLRN1) results in progressive loss of vision and hearing in Usher syndrome IIIA (USH3A) patients…”
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A small molecule mitigates hearing loss in a mouse model of Usher syndrome III by Alagramam, Kumar N, Gopal, Suhasini R, Geng, Ruishuang, Chen, Daniel H-C, Nemet, Ina, Lee, Richard, Tian, Guilian, Miyagi, Masaru, Malagu, Karine F, Lock, Christopher J, Esmieu, William R K, Owens, Andrew P, Lindsay, Nicola A, Ouwehand, Krista, Albertus, Faywell, Fischer, David F, Bürli, Roland W, MacLeod, Angus M, Harte, William E, Palczewski, Krzysztof, Imanishi, Yoshikazu

“…A small molecule identified from high-throughput screening and optimization specifically stabilizes a disease-linked CLRN1 protein, delivering it to its site…”
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Zebrafish Models for the Mechanosensory Hair Cell Dysfunction in Usher Syndrome 3 Reveal That Clarin-1 Is an Essential Hair Bundle Protein by Gopal, Suhasini R, Chen, Daniel H-C, Chou, Shih-Wei, Zang, Jingjing, Neuhauss, Stephan C F, Stepanyan, Ruben, McDermott, Jr, Brian M, Alagramam, Kumar N

“…Usher syndrome type III (USH3) is characterized by progressive loss of hearing and vision, and varying degrees of vestibular dysfunction. It is caused by…”
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Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells by Geng, Ruishuang, Sotomayor, Marcos, Kinder, Kimberly J, Gopal, Suhasini R, Gerka-Stuyt, John, Chen, Daniel H-C, Hardisty-Hughes, Rachel E, Ball, Greg, Parker, Andy, Gaudet, Rachelle, Furness, David, Brown, Steve D, Corey, David P, Alagramam, Kumar N

“…In hair cells of the inner ear, sound or head movement increases tension in fine filaments termed tip links, which in turn convey force to mechanosensitive ion…”
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