Search Results - "Gopal, P P"
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Performance Evaluation of Best Feature Subsets for Crop Yield Prediction Using Machine Learning Algorithms
Published in Applied artificial intelligence (07-06-2019)“…The rapid innovations and liberalized market economy in agriculture demand accuracy in Crop Yield Prediction (CYP). In accurate prediction, machine learning…”
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Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity
Published in Biochemical journal (11-12-2020)“…Regarded as constitutively active enzymes, known to participate in many, diverse biological processes, the intracellular regulation bestowed on the CK1 family…”
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Proteomic approaches advancing targeted protein degradation
Published in Trends in pharmacological sciences (Regular ed.) (01-11-2023)“…Targeted protein degradation (TPD) is an exciting new modality for inducing target protein destruction in cells by harnessing cellular degradation pathways…”
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4
A novel approach for efficient crop yield prediction
Published in Computers and electronics in agriculture (01-10-2019)“…•Thirty years of paddy crop related real data of the districts of Tamil Nadu State in India are collected for this work.•In this work we proposed a hybrid…”
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Vaccination uptake amongst older adults from minority ethnic backgrounds: A systematic review
Published in PLoS medicine (04-11-2021)“…Older adults from minority ethnic backgrounds are at increased risk of contracting COVID-19 and developing severe infection and have increased risk of…”
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The specificities of small molecule inhibitors of the TGFß and BMP pathways
Published in Cellular signalling (01-11-2011)“…Small molecule inhibitors of type 1 receptor serine threonine kinases (ALKs1-7), the mediators of TGFß and BMP signals, have been employed extensively to…”
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The FAM83 family of proteins: from pseudo-PLDs to anchors for CK1 isoforms
Published in Biochemical Society transactions (19-06-2018)“…The eight members of the FAM83 (FAMily with sequence similarity 83) family of poorly characterised proteins are only present in vertebrates and are defined by…”
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Impact of big data analytics on supply chain performance: an analysis of influencing factors
Published in Annals of operations research (01-02-2024)“…This paper aims to understand the impact of big data analytics on the retail supply chain. For doing so, we set our context to select the best big data…”
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Advances in targeted degradation of endogenous proteins
Published in Cellular and molecular life sciences : CMLS (01-07-2019)“…Protein silencing is often employed as a means to aid investigations in protein function and is increasingly desired as a therapeutic approach. Several types…”
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Influence of reduced graphene oxide addition on kerf width in abrasive water jet machining of nanofiller added epoxy-glass fibre composite
Published in PloS one (16-08-2022)“…The present study aims to develop a novel hybrid polymer composite with reduced graphene oxide (rGO) as filler and optimize its Abrasive Water Jet Machining…”
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Optimized second-generation CRY2–CIB dimerizers and photoactivatable Cre recombinase
Published in Nature chemical biology (01-06-2016)“…Identification of minimal functional CRY2–CIB1 domains and mutations that increased CRY2 photocycle lifetimes combined with the development of an improved…”
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Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons
Published in Proceedings of the National Academy of Sciences - PNAS (21-03-2017)“…Ribonucleoprotein (RNP) granules are enriched in specific RNAs and RNA-binding proteins (RBPs) and mediate critical cellular processes. Purified RBPs form…”
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Sustainable supply chain practices: an empirical investigation on Indian automobile industry
Published in Production planning & control (02-01-2016)“…The purpose of this research study is to analyze sustainable supply chain (SSC) management practices for Indian automobile industry and to identify the…”
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Analysing critical success factors to implement sustainable supply chain practices in Indian automobile industry: a case study
Published in Production planning & control (09-09-2016)“…The aim of this article is to analyse the critical success factors (CSFs) behind the successful implementation of sustainable supply chain practices in Indian…”
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15
Global magnitude of visual impairment caused by uncorrected refractive errors in 2004
Published in Bulletin of the World Health Organization (2008)“…Estimates of the prevalence of visual impairment caused by uncorrected refractive errors in 2004 have been determined at regional and global levels for people…”
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Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease
Published in Molecules (Basel, Switzerland) (13-09-2024)“…The Caf1/CNOT7 nuclease is a catalytic component of the Ccr4-Not deadenylase complex, which is a key regulator of post-transcriptional gene regulation. In…”
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Target protein localization and its impact on PROTAC-mediated degradation
Published in Cell chemical biology (20-10-2022)“…Proteolysis-targeting chimeras (PROTACs) bring a protein of interest (POI) into spatial proximity of an E3 ubiquitin ligase, promoting POI ubiquitylation and…”
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OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3
Published in Nature communications (27-09-2013)“…SMAD transcription factors are key intracellular transducers of TGFβ cytokines. SMADs are tightly regulated to ensure balanced cellular responses to TGFβ…”
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The physician-scientist, 75 years after Vannevar Bush–rethinking the ‘bench’ and ‘bedside’ dichotomy
Published in Nature medicine (01-04-2020)“…Vannevar Bush enshrined the ‘basic’ and ‘applied’ research dichotomy on which much of science policy is still built 75 years later. However, it is time to…”
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Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System
Published in Cell chemical biology (17-09-2020)“…The affinity-directed protein missile (AdPROM) system utilizes specific polypeptide binders of intracellular proteins of interest (POIs) conjugated to an E3…”
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